The use of rivaroxaban in deep venous thrombosis associated with vena cava inferior agenesis

Abstract

İnferior vena kava agenezisi, derin ven trombozu ile sonuçlanabilen nadir bir anomalidir. En etkili tedavi yöntemi, optimum tedavi süresi ve antikoagülan seçimine ilişkin kesin bilimsel veri yoktur. Bu yazıda venöz staz semptomları ve heterozigot trombofilik mutasyonların varlığı nedeni ile yaşam boyu antikoagülasyon tedavisi olarak rivaroksaban verilen inferior vena kava agenezisi ile ilişkili derin ven trombozu olan 18 yaşında bir erkek olgu sunuldu.Anah tar söz cük ler: İnferior, rivaroksaban, trombofili, vasküler malformasyon, ven trombozu, vena kava.

Venous Thromboembolism in a Patient with Interrupted Inferior Vena Cava and Compressed Azygos Continuation: A Case Report and Review of Literature

“…A two-sided P value <.05 was considered statistically significant. A total of 51 English publications, 7-57 encompassing 112 patients with VTE due to underlying IVC agenesis and azygos continuation were included in this study (Supplementary Table 1). Most of the published literature was case reports or case series.…”

“…The majority of patients discharged with lifelong anticoagulation did not experience recurrent VTE, where failure of warfarin therapy was the only reason of recurrence. 31,48,55 Parma et al initially planned a 12-month oral anticoagulation therapy, but the patient, who had a heterozygous factor V Leiden mutation, presented with recurrent DVT 8 years later and required lifelong oral anticoagulation. 17 Our patient understood his underlying condition and continued his Rivaroxaban 10 mg daily prophylactic therapy.…”

Direct Oral Anticoagulants for Inferior Vena Cava Agenesis

“… 19 , 20 Therefore only case reports have evaluated the use of extended DOAC therapy. 8 , 21 , 22 In addition to anticoagulation, the use of elastic stockings should be encouraged as adjuvant therapy in order to prevent venous insufficiency and ulceration in these patients. Patients should also be advised to avoid additional risk factors, such as prolonged immobilization and oral contraceptives.…”

Infrarenal inferior vena cava agenesis presenting as acute abdomen and hydronephrosis – case report

“…Although IVCA is frequently asymptomatic and incidentally found on imaging or during surgeries [9] , it is often associated with other gastrointestinal, vascular, pulmonary, and cardiac malformations [15] . In our case, echocardiography revealed MVP.…”