The use of SD-OCT in the differential diagnosis of dots, spots and other white retinal lesions

Zaharova, E. V.; Sherman, Jerome

doi:10.2147/eb.s23208

Cited by 13 publications

(5 citation statements)

References 28 publications

(64 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1 The well-documented clinical study by Newman et al of a large multiethnic cohort of patients with RDH5related FAP is a significant scientific contribution. 1 It is unfortunate that they failed to acknowledge 1) more than a decade of previous studies demonstrating subretinal drusenoid deposit-like deposits in FAP [2][3][4][5][6][7] and in other disorders including age-related macular degeneration, 8 pseudoxanthoma elasticum, 9 Sorsby macular dystrophy, 10 vitamin A deficiency, 11 and pre-eclampsia 12,13 or 2) "target" signs in the infrared images of subretinal drusenoid deposits that were first reported in 2011. 7,14,15 Target signs arise because more scanning laser ophthalmoscope infrared radiation is reflected back to its detector from the central area of a dome-shaped subretinal drusenoid deposit lesion (oriented largely perpendicular to the scanning beam) than its sloping sides (positioned oblique to incoming laser radiation).…”

Section: Correspondencementioning

confidence: 99%

Correspondence

Ledesma-Gil

Querques

Souied

et al. 2022

Retina

View full text Add to dashboard Cite

Section: Correspondencementioning

confidence: 99%

Correspondence

Ledesma-Gil

Querques

Souied

et al. 2022

Retina

View full text Add to dashboard Cite

“…In the inner retinal layers, Schreur et al found that HRF were better responsive to anti-VEGF treatment[ 19 ]. In the OPL and ONL where hard exudates mainly distribute within [ 39 ], we observed the most HRF, indicating that the HRF are closely associated with hard exudates. Our current result is consistent with the result that the number of HRF correlated with the presence of hard exudate.…”

Section: Discussionmentioning

confidence: 73%

Comparison of hyperreflective foci in macular edema secondary to multiple etiologies with spectral-domain optical coherence tomography: An observational study

et al. 2022

View full text Add to dashboard Cite

Background Hyperreflective foci (HRF) features in macular edema associated with different etiologies may indicate the disease pathogenesis and help to choose proper treatment. The goal of this study is to investigate the retinal microstructural features of macular edema (ME) secondary to multiple etiologies with spectral-domain optical coherence tomography (SD-OCT) and analyze the origin of HRF in ME. Methods This was a retrospective study. SD-OCT images were reviewed to investigate macular microstructural features such as the number and distribution of HRF and hard exudates and the internal reflectivity of the cysts. The differences in microstructural features between groups and the correlations between the number of HRF and other parameters were analyzed. Results A total of 101 eyes with ME from 86 diabetic (diabetic macular edema, DME) patients, 51 eyes from 51 patients with ME secondary to branch retinal vein occlusion (branch retinal vein occlusion-macular edema, BRVO-ME), 59 eyes from 58 central retinal vein occlusion (central retinal vein occlusion-macular edema, CRVO-ME) patients, and 26 eyes from 22 uveitis (uveitic macular edema, UME) patients were included in this study. The number of HRF, the frequency of hard exudates and the enhanced internal reflectivity of the cysts were significantly different among the groups. The number of HRF in the DME group was significantly higher than that in the other groups (all P < 0.05). The frequency of hard exudates and enhanced internal reflectivity of the cysts in the DME group were significantly higher than ME secondary to other etiologies (all P < 0.001). Within the DME group, the number of HRF in the patients with hard exudates was significantly higher than that in the patients without hard exudates (P < 0.001). Conclusion HRF detected with SD-OCT were more frequent in DME patients than in BRVO-ME, CRVO-ME, or UME patients. The occurrence of HRF was correlated with the frequency of hard exudates. HRF may result from the deposition of macromolecular exudates in the retina, which is speculated to be a precursor of hard exudates.

show abstract

“…CNV was obvious after we did a fluorescein angiography. SD-OCT is of high utility in the diagnosis and follow-up of POHS, as it provides a precise layer-bylayer analysis of the retina with a better resolution than the fundoscopy or fundus photography [9]. In our case, the use of SD-OCT, along with clinical examination were of great value to monitor improvement following bevacizumab treatment.…”

Section: Case Presentationmentioning

confidence: 77%

Presumed Ocular Histoplasmosis Syndrome in the Middle East: A Case Report

Macaron¹,

Orra

et al. 2021

Int J Clin Res

View full text Add to dashboard Cite

Background:Presumed ocular histoplasmosis syndrome (POHS) occurs secondary to infection with Histoplasma Capsulatum (HC), which is an endemic organism in many tropical areas, especially in the United States. However, it has never been proven that HC directly causes POHS, hence the name presumed ocular histoplasmosis syndrome. Patients are usually asymptomatic, but some may present with blurring of central vision. Case Report:A 15-year-old girl, previously healthy, presented with a 2-months history of visual disturbance of the right eye. On physical examination, the visual acuity of the left eye was 20/20 while the right eye was only seeing “hand motion”. Fundus exam of the right eye showed juxtapapillary infiltrates with serous macular detachment, and small retinal and choroidal lesions, while the left eye showed only some small retinal and choroidal lesions. Fluorescein angiography of both eyes showed evidence of chorioretinitis with probable choroidal neovascularization (CNV). The diagnosis of POHS was made and the patient was treated with bevacizumab injections. Follow-up was done clinically and through spectral domain optical coherence tomography (SD-OCT) and showed marked improvement at the level of the macular thickness and CNV. Conclusion: Diagnosing POHS can be quite challenging, especially in cases coming from non-endemic areas. Our case emphasizes the importance of considering POHS in patients presenting with visual disturbance, even in these non-endemic areas, through a careful clinical evaluation and appropriate imaging modalities.

show abstract

The use of SD-OCT in the differential diagnosis of dots, spots and other white retinal lesions

Cited by 13 publications

References 28 publications

Correspondence

Correspondence

Comparison of hyperreflective foci in macular edema secondary to multiple etiologies with spectral-domain optical coherence tomography: An observational study

Presumed Ocular Histoplasmosis Syndrome in the Middle East: A Case Report

Contact Info

Product

Resources

About