The use of serum anti-Mullerian hormone (AMH) levels and antral follicle count (AFC) to predict the number of oocytes collected and availability of embryos for cryopreservation in IVF

Kotanidis, Lazaros; Nikolettos, Konstantinos; Petousis, Stamatios; Asimakopoulos, Byron; Chatzimitrou, E; Kolios, George; Nikolettos, Nikos

doi:10.1007/s40618-016-0521-x

Cited by 24 publications

(17 citation statements)

References 31 publications

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“…AMH has been shown to be a strong predictor of ovarian response to exogenous gonadotropins during COH for IVF as well as outcomes such as oocyte yield [18], blastocyst formation [19], blastocyst aneuploidy [20], and surplus embryo cryopreservation at the various stages [21–26]. There are conflicting data regarding the ability of AMH to predict clinical pregnancy rates and live birth rates [27–31].…”

Section: Discussionmentioning

confidence: 99%

Serum Antimüllerian hormone does not predict elevated progesterone levels among women who undergo controlled ovarian hyperstimulation for in vitro fertilization

Kavoussi

Chen

Hunn

et al. 2019

Reprod Biol Endocrinol

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Serum Antimüllerian hormone (AMH) has been shown to predict various in vitro fertilization (IVF) outcomes. AMH and progesterone (P) are products of granulosa cells of the ovary. Since overall granulosa cell number directly correlates with oocyte number and AMH production, the aim of this study is to evaluate whether or not serum AMH is associated with elevated P during controlled ovarian hyperstimulation (COH) for IVF. For this retrospective study, data were abstracted from charts of first IVF cycles of women ( n = 201) who had undergone COH between May 2014 and May 2017. Groups were as follows: (A) AMH < 1 ng/mL ( n = 32), (B) AMH 1–3.99 ng/mL ( n = 109), (C), AMH ≥ 4 ng/mL ( n = 60). The primary outcome measure was serum P level at trigger prior to oocyte retrieval. Mean serum P levels among groups A, B, and C were 0.92 ng/mL, 0.96 ng/mL, and 0.84 ng/mL, respectively. One-way ANOVA showed that there was no difference in mean serum P level among groups A, B, and C ( p -value = 0.28). Multivariable linear regression with P as the dependent variable showed that total gonadotropin dose and peak estradiol level on day of trigger each had a significant positive relationship with P, and clinical pregnancy had a significant negative relationship. Although AMH is a predictor of certain IVF outcomes, AMH is not a predictor of elevated serum P level at trigger among women who undergo COH for IVF.

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Section: Discussionmentioning

confidence: 99%

Serum Antimüllerian hormone does not predict elevated progesterone levels among women who undergo controlled ovarian hyperstimulation for in vitro fertilization

Kavoussi

Chen

Hunn

et al. 2019

Reprod Biol Endocrinol

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“…However, they did not investigate the possible association of AMH levels with pregnancy rate. 36 Our study used a short-agonist stimulation protocol, which would be indicated in a population of expected low responders. Counselling these women often proves to be very difficult, since live birth rates are relatively low in this patient group.…”

Section: Discussionmentioning

confidence: 99%

Correlation of serum anti-Müllerian hormone levels with positive in vitro fertilization outcome using a short agonist protocol

Mantzavinos

Vlahos

Rizos

et al. 2017

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OBJECTIVE: We examined the predictive ability of anti-Müllerian hormone (AMH) for clinical pregnancy in women who underwent in vitro fertilization (IVF) cycles in a short agonist protocol. DESIGN: This is a retrospective cohort study of 222 women undergoing their first IVF attempt between June 2010 and March 2016. Multivariate logistic regression analysis was performed to evaluate the independent associations between clinical pregnancy and its possible predictors. RESULTS: 14.9% of cycles were cancelled, >3 oocytes were retrieved in 55.4% of cycles and embryo transfer was performed in 70.7% of cases. Live birth was the final outcome in 19.8% of subjects, miscarriage occurred in 4.1%, whereas no pregnancy occurred in the remaining 76.1% of the study sample. The number of oocytes, number of embryos, embryo transfer rate and pregnancy rates were positively associated with serum AMH concentrations (p <0.001, for each association). When analyzed by age quartiles, the overall association between AMH and clinical pregnancy rates was evident across all age strata. CONCLUSIONS: Serum AMH levels are a strong predictive marker of clinical pregnancy in women undergoing a short agonist IVF protocol. There is also a strong association with cancellation rate, number of oocytes retrieved, poor response (≤3 oocytes), number of embryos, embryo transfer rate and live birth rates.

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“…Measurements of serum concentrations of AMH have been used along with other measurements, such as for FSH, luteinizing hormone (LH), and E2, for a wide variety of clinical applications. 11 , 22 , 56 , 57 , 58 The clinical use of AMH has advantage over other assays because of its relatively stable level across the menstrual cycle. 50 , 59 , 60 Nevertheless, recent studies have suggested that there is a considerable amount of variation in the level of AMH across cycles in certain women, which implies a risk of misclassification if the variation is beyond 20%.…”

Section: Development Of Amh Assaysmentioning

confidence: 99%

Clinical Applications of Serum Anti-Müllerian Hormone Measurements in Both Males and Females: An Update

Zhang

et al. 2021

The Innovation

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The use of serum anti-Mullerian hormone (AMH) levels and antral follicle count (AFC) to predict the number of oocytes collected and availability of embryos for cryopreservation in IVF

Cited by 24 publications

References 31 publications

Serum Antimüllerian hormone does not predict elevated progesterone levels among women who undergo controlled ovarian hyperstimulation for in vitro fertilization

Serum Antimüllerian hormone does not predict elevated progesterone levels among women who undergo controlled ovarian hyperstimulation for in vitro fertilization

Correlation of serum anti-Müllerian hormone levels with positive in vitro fertilization outcome using a short agonist protocol

Clinical Applications of Serum Anti-Müllerian Hormone Measurements in Both Males and Females: An Update

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