The use of silver-zinc-allantoin powder for the prehospital treatment of burns

Klippel, Allen P.; Margraf, Harry W.; Covey, Thomas H.

doi:10.1016/s0361-1124(77)80492-9

Cited by 7 publications

(3 citation statements)

References 4 publications

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“…Allantoin and TMAO levels were also increased in the ECLP group; however, no increase was observed in the YCLP group. Allantoin, widely used as a skin care agent, has anti-inflammatory, endotoxin-binding and cell-growth-promoting activity [43]. Its increase in sham rats suggested that those rats had stronger regeneration capacity than the middle-aged rats, resulting in more effective self-repair after injury.…”

Section: Discussionmentioning

confidence: 99%

Metabolomics Coupled with Transcriptomics Approach Deciphering Age Relevance in Sepsis

Xu¹,

Liao²,

Li³

et al. 2019

Aging and disease

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Sepsis is a severe disease frequently occurred in the Intenisive Care Unit (ICU), which has a very high morbidity and mortality, especially in patients aged over 65 years. Owing to the aging effect and the ensuing deterioration of body function, the elder patients may have atypical responses to sepsis. Diagnosis and pathogenesis of sepsis in this population are thus difficult, which hindered effective treatment and management in clinic. To investigated age effects on sepsis, 158 elderly septic patients and 71 non-septic elderly participants were enrolled, and their plasma samples were collected for transcriptomics (RNA-seq) and metabolomics (NMR and GC-MS) analyses, which are both increasingly being utilized to discover key molecular changes and potential biomarkers for various diseases. Protein-protein interaction (PPI) analysis was subsequently performed to assist cross-platform integration. Real time polymerase chain reaction (RT-PCR) was used for validation of RNA-seq results. For further understanding of the mechanisms, cecal ligation and puncture (CLP) experiment was performed both in young and middle-aged rats, which were subjected to NMR-based metabolomics study and validated for several key inflammation pathways by western blot. Comprehensive analysis of data from the two omics approaches provides a systematic perspective on dysregulated pathways that could facilitate the development of therapy and biomarkers for elderly sepsis. Additionally, the metabolites of lactate, arginine, histamine, tyrosine, glutamate and glucose were shown to be highly specific and sensitive in distinguishing septic patients from healthy controls. Significant increases of arginine, trimethylamine N-oxide and allantoin characterized elderly patient incurred sepsis. Further analytical and biological validations in different subpopulations of septic patients should be carried out, allowing accurate diagnostics and precise treatment of sepsis in clinic.

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Section: Discussionmentioning

confidence: 99%

Metabolomics Coupled with Transcriptomics Approach Deciphering Age Relevance in Sepsis

Xu¹,

Liao²,

Li³

et al. 2019

Aging and disease

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“…The selection of characteristic compounds for holistic identification of LWDHP was based on several principles: (i) all component herbs should be covered and the number of characteristic compounds from each herb should be no less than two; (ii) compounds with pharmacological properties were preferred; (iii) those chemical representative compounds with high content would be concerned. For RD, allantoin was reported to possess anti‐inflammatory effects, 22 and although two other compounds have not been identified, all the three compounds were selected for identification of RD. Compounds 56 and 57 were chosen for the identification of Poria.…”

Section: Resultsmentioning

confidence: 99%

An integrated strategy for holistic quality identification of Chinese patent medicine: Liuwei Dihuang Pills as a case study

Wang

Zhang

et al. 2020

Phytochemical Analysis

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Introduction Liuwei Dihuang Pills (concentrated pills, simplified as LWDHP), one of the most famous classic Chinese Patent Medicine (CPM), is produced by hundreds of pharmaceutical manufacturers with billions of Chinese yuan (CNY) in annual sales. However, current quality identification of LWDHP mainly relies on a thin‐layer chromatography (TLC) method that is complicated and deficient. Objective The goal of this study is to simplify the identification process and provide a more comprehensive quality assessment method of LWDHP by developing an integrated strategy based on liquid chromatography coupled with mass spectrometry (LC‐MS) and multivariate statistical analysis. Method Ultra‐high‐performance liquid chromatography coupled with quadrupole‐time of flight mass spectrometry (UHPLC/QTOF‐MS) was employed to perform qualitative analyses of a home‐made LWDHP and to establish a stably characteristic compound library by analysis of batches of its component herbs. Then selective ion monitoring (SIM) of single MS was utilised to develop a rapid identification method based on the UHPLC/QTOF‐MS analysis result. Multivariate statistical analysis was subsequently used for the quality assessment of different commercial samples. Results Seventy‐eight characteristic compounds were characterised, and 68 of them were recorded to establish a stably characteristic compound library. Thirty‐one compounds were selected from the library for the establishment of SIM identification method. Good specificity, capability, and feasibility had been respectively verified by the analysis of blank sample, negative control (NC) preparation samples, home‐made LWDHP sample, and commercial sample. Multivariate statistical analysis of 20 batches of commercial LWDHP samples revealed the quality consistency of the same vendor's product and quality difference between diverse vendors' products. Conclusion The SIM identification method by a single analysis could significantly simplify the identification process of LWDHP, and it was performed in a holistic mode for no less than two compounds of each component herb monitored. Moreover, it could also be combined with multivariate statistical analysis to conduct quality assessments of batches of samples. The integrated strategy used in the study of LWDHP could be applied for the identification of other CPM as well.

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“…In fact, several hydantoin derivatives are found to be valuable in agrochemistry and they act as herbicides, fungicides and insecticides etc (Figure ). Moreover, hydantoins have a wide range of applications, namely, dye‐sensitized solar cells, C−H activation, chiral auxiliaries and cosmetic industry . Additionally, hydantoins are important intermediates for syntheses of natural and non‐natural α‐amino acids in racemic form through alkaline degradation and dynamic kinetic resolution .…”

Section: Introductionmentioning

confidence: 99%

Multicomponent Approach to Hydantoins and Thiohydantoins Involving a Deep Eutectic Solvent

Kotha

Gupta

Aswar

2019

Chemistry An Asian Journal

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We report an efficient synthetic strategy to diverse hydantoins and thiohydantoins involving a three‐component reaction with the aid of deep eutectic solvent. Here, N,N′‐dimethyl urea and N,N′‐dimethyl thiourea play a dual role as reactant and reaction medium along with l‐(+)‐tartaric acid. The three‐component reaction provides an easy access to 5‐amino‐1,3‐dialkyl‐substituted hydantoins and thiohydantoins in good yields.

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The use of silver-zinc-allantoin powder for the prehospital treatment of burns

Cited by 7 publications

References 4 publications

Metabolomics Coupled with Transcriptomics Approach Deciphering Age Relevance in Sepsis

Metabolomics Coupled with Transcriptomics Approach Deciphering Age Relevance in Sepsis

An integrated strategy for holistic quality identification of Chinese patent medicine: Liuwei Dihuang Pills as a case study

Multicomponent Approach to Hydantoins and Thiohydantoins Involving a Deep Eutectic Solvent

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