The purpose of this article was to present a new, integrative, case-based educational approach for neonatal advanced practice nursing students in a hybirdized long-distance program at the University of Washington. The theoretical background is based on a holistic, systems-based, and case-based approach to learning. A guideline for instructors will be included, emphasizing recommendations of Benner et al for teaching a sense of salience, integration, critical reasoning, and role formation. Such a holistic approach to neonatal advanced practice nursing education may maximize the unification of knowledge with practice and improve learning, at a time when resources are few.