The use of single particle mechanical properties for predicting the compressibility of pharmaceutical materials

Govedarica, Biljana; Ilić, Ilija; Šibanc, Rok; Dreu, Rok; Srčič, Stanko

doi:10.1016/j.powtec.2012.03.030

Cited by 36 publications

(16 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Govedarica et al studied deformational behavior of common pharmaceutical excipients (microcrystalline cellulose, lactose, dicalcium phosphate anhydrous, corn starch, isomalt, and sodium chloride) by instrumented nanoindentation (112). The measured values are summarized in Table III.…”

Section: Nanoindentation In Prediction Of Bulk Mechanical Propertiesmentioning

confidence: 99%

Application of instrumented nanoindentation in preformulation studies of pharmaceutical active ingredients and excipients

2016

Self Cite

View full text Add to dashboard Cite

Application of instrumented nanoindentation in preformulation studies of pharmaceutical active ingredients and excipients # Nanoindentation allows quantitative determination of a material's response to stress such as elastic and plastic deformation or fracture tendency. Key instruments that have enabled great advances in nanomechanical studies are the instrumented nanoindenter and atomic force microscopy. The versatility of these instruments lies in their capability to measure local mechanical response, in very small volumes and depths, while monitoring time, displacement and force with high accuracy and precision. This review highlights the application of nanoindentation for mechanical characterization of pharmaceutical materials in the preformulation phase (primary investigation of crystalline active ingredients and excipients). With nanoindentation, mechanical response can be assessed with respect to crystal structure. The technique is valuable for mechanical screening of a material at an early development phase in order to predict and better control the processes in which a material is exposed to stress such as milling and compression.

show abstract

Section: Nanoindentation In Prediction Of Bulk Mechanical Propertiesmentioning

confidence: 99%

Application of instrumented nanoindentation in preformulation studies of pharmaceutical active ingredients and excipients

2016

Self Cite

View full text Add to dashboard Cite

show abstract

“…In addition, this study also implicitly connects brittleness or ductility of compact (or powder mass under compaction) to the same properties of particles, which would be interesting to find out how these are correlated. Recent advancement of experimental methods, which can determine mechanical properties of sub-micrometer sized test specimen, definitely allow quantitative investigation of particles (Govedarica et al, 2012;Karamchandani et al, 2016).…”

Section: Quality: Mechanical Defectsmentioning

confidence: 99%

“…One of notable properties that has not been studied from this perspective include actual mechanical properties of individual particle and evolution of contacts between particles during compaction in relation to bulk responses of powder en masse during compaction or mechanical properties of resulting compacts. Recently, there have been attempts to investigate mechanical properties of particle with powder compaction using nanoindentation as a mean to determine particle's mechanical property (Cao et al, 2010;Govedarica et al, 2012). Furthermore Portnikov and Kalman (2015) investigated the effect of temperature on elastic properties individual particles and showed that the effective modulus of elasticity decreases while temperature of particles increases.…”

Section: Quality: Strengthmentioning

confidence: 99%

“…In other words, it is required for an indentation tip to be much harder than subjected powder compacts with large enough dimension compared to the indentation to ensure an accurate hardness measurement, which is not always straightforward to implement especially for novel materials or materials with less known surface characteristics or mechanical properties. Indentation hardness has been recognized as a useful and promising tool in mechanical characterization of particles with the recent development in micro-indentation tester, especially for the advancement of Atomic Force Microscopy (AFM) (Cao et al, 2010;Masterson and Cao, 2008;Meier et al, 2009;Willems et al, 1993) or nanoindenter (Gibson et al, 2015;Govedarica et al, 2012;Taylor et al, 2004). In general, a caution should be exercised when fundamental mechanical properties, such as Young's modulus and Poisson's ratio when the simplest elasticity is assumed, are estimated from indentation hardness test results.…”

Section: Quality: Hardnessmentioning

confidence: 99%

“…In general, a caution should be exercised when fundamental mechanical properties, such as Young's modulus and Poisson's ratio when the simplest elasticity is assumed, are estimated from indentation hardness test results. For example, Govedarica et al (2012) used Sneddon (1965's equations which assumes semi-infinite half-space of subject material compared to the indentor geometry. Taylor et al (2004) used DuncanHewitt and Weatherly (1989)'s study based on a semiempirical fracture mechanics to estimate brittleness based on the ratio of the hardness and elastic modulus based on the indentation geometry of a conventional Vickers Hardness test.…”

Section: Quality: Hardnessmentioning

confidence: 99%

See 2 more Smart Citations

Critical Review on Engineering Mechanical Quality of Green Compacts using Powder Properties

Pandeya²,

Karamchandani

et al. 2018

KONA

View full text Add to dashboard Cite

For processes involving particulate materials, mechanical properties of green compacts are of great interest when they are final or intermediate products. Optimal quality of green compacts is achieved usually with empirical approaches, i.e., unexpected issues in processes or products' quality are usually mitigated by time and resource consuming trial-and-error methods. Issues of the powder compaction are commonly observed when there are problems in feed materials or operational conditions even without any substantial change in a formula. Such divergent behavior of particulate materials is especially problematic for product developments and reliable operations. It has been widely accepted hypothesis that properties of particles are determinants of mechanical behavior of powder during compaction and the quality of resulting compacts. With recent developments in nanotechnology, characterization and engineering of individual particles at a microscopic or sub-microscopic scale are now feasible. Leveraging recent technological advancements, there has been a good progress in regard to quantitative understanding of mechanical relationships between properties of particles, particle system and final product. This review highlights the recent developments and gaps in engineering mechanical quality of powder compacts in conjunction with the characterization of particle systems and compaction at multiple scales.

show abstract

Process Simulation and Control for Continuous Pharmaceutical Manufacturing of Solid Drug Products

Ierapetritou

Escotet‐Espinoza

Singh

2017

Continuous Manufacturing of Pharmaceuticals

View full text Add to dashboard Cite

The use of single particle mechanical properties for predicting the compressibility of pharmaceutical materials

Cited by 36 publications

References 29 publications

Application of instrumented nanoindentation in preformulation studies of pharmaceutical active ingredients and excipients

Application of instrumented nanoindentation in preformulation studies of pharmaceutical active ingredients and excipients

Critical Review on Engineering Mechanical Quality of Green Compacts using Powder Properties

Process Simulation and Control for Continuous Pharmaceutical Manufacturing of Solid Drug Products

Contact Info

Product

Resources

About