The Use of Sodium Hypochlorite Solution for (n,γ)⁹⁹Mo/^99mTc Generator Based on Zirconium-Based Material (ZBM)

Abstract

]molybdate was then packed into generator column, then eluted with 10 × 1 mL of saline followed by 1 × 5 mL of NaOCl solution. The NaOCl solution concentrations used were 0.5%; 1%; 3%; and 5% for each column, respectively. This study resulted in a ZBM which has a 99 Mo adsorption capacity of 167.5 ± 3.4 mgMo/g ZBM, as well as in a yield eluate of 99m Tc of up to 70%, and the find that the optimum NaOCl concentration was 3%. The use of sodium hypochlorite solution affected 99 Mo breakthrough. The higher sodium hypochlorite concentration used, the more 99 Mo breaktrough exist on 99m Tc eluate.

PENGARUH AKTIVITAS 99Mo TERHADAP PROFIL RENDEMEN 99mTc PADA GENERATOR 99Mo/99mTc DENGAN KOLOM MATERIAL BERBASIS ZIRKONIUM (MBZ)

“…MBZ yang digunakan dalam penelitian ini adalah batch 013 dan 014 dengan ukuran/diameter 300-700 µm, yang disintesis dari zirkonium klorida, isopropanol dan tetrahidrofuran dengan metode pengadukan dan pemanasan. MBZ hasil sintesis dilapisi tetraetil ortosilikat agar tidak pecah proses penyerapan [15].…”

“…Untuk mengatasi berkurangnya pasokan 99 Mo di dunia, berbagai metode telah dikembangkan untuk Salah satu aspek yang masih perlu ditingkatkan dari teknologi generator 99 Mo/ 99m Tc berbasis MBZ adalah persentase 99m Tc yang diperoleh dari hasil elusi kolom MBZ [15]. Persentase rendemen 99m Tc yang dihasilkan oleh MBZ berkisar antara 5-80% dan cenderung rendah.…”

Validation of Simple Uv-Vis Spectrophotometry Method Based on Ich Q2 (R1) Guideline for the Analysis of Sodium Hypochlorite Using Rhodamine B

“…In dentistry, the NaOCl is routinely used as endodontic irigant. Another application of the chemical is as reagent in analytical chemistry (Abdulrahman & Basavaiah, 2012) Tc generator based on zirconium-based material (ZBM), which can enhance the yield of 99mTc (Saptiama et al, 2015).…”

Synthesis of Nano-α-Al2O3 for 99Mo Adsorbent

“…Meanwhile, the Centre for Radioisotopes and Radiopharmaceutical Technology-National Nuclear Energy Agency (PTRR-BATAN) has also developed a zirconium-based material (ZBM) for use as 99 Mo adsorbent [6][7][8][9]. This material has been succesfully synthesized and used as 99 Tc generator.…”