The use of sonochemistry in the asymmetric epoxidation of substituted chalcones with sodium perborate tetrahydrate

Development of the Juliá−Colonna Asymmetric Epoxidation Reaction: Part 1. Preparation and Activation of the Polyleucine Catalyst

“…Three protocols for the Julia ´-Colonna reaction have been reported. 15 The original method employed . 6 The second, carried out in a homogeneous solvent mixture of water and DME, utilises sodium percarbonate as both oxidant and base and is known as the percarbonate protocol.…”

Sodium perborate and sodium percarbonate: further applications in organic synthesis

“…Virtually the same approach, but with the added effect of 7 hours of sonication of a variety of chalcones, has given, again, excellent yields of epoxides, but the ee values were somewhat lower than those obtained in the Roberts study. 29 Two recently-published patents 30,31 refer to SPB and SPC in a list of many oxidants for epoxidation of pyronenes as precursors for vitamin A, PVC stabilisers, or epoxy resin modifiers. However, no examples of use of persalts as oxidants are given in either patent, and there is therefore some doubt as to whether these were in fact employed.…”

LiOH·H2O as a novel dual activation catalyst for highly efficient and easy synthesis of 1,3-diaryl-2-propenones by Claisen–Schmidt condensation under mild conditions

“…1,3-Diaryl-2-propenones inhibit various enzymes such as CysLT 1 [19], COX/5-LOX [20], EGFR tyrosine kinase [21] and tyrosinase [22] that play crucial role in the biochemical pathways of different diseases. Chalcones are key precursors in the synthesis of a large array of biologically important heterocycles [23][24][25][26][27][28][29][30] and 1,4-diketones [31]. Thus, the synthesis of chalcones has generated vast interest to organic/medicinal chemists.…”