The Use of Specific and Non-Specific Questionnaires to Assess Quality of Life in Patients With Functional Disorders of Intestine

Шкляев, А. Е.; Горбунов, Ю. В.

doi:10.20514/2226-6704-2016-6-4-53-57

Cited by 5 publications

(2 citation statements)

References 3 publications

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“…У пациентов с ФД часто встречается гиперчувствительность желудка и верхнего отдела тонкой кишки к механическим, химическим и термическим воздействиям [9,14,15]. В количественной характеристике имеющейся у пациентов гастроэнтерологической симптоматики важное значение принадлежит определению качества жизни с использованием специфического опросника [16,17,18]. Однако профиль симптомов не является надежным инструментом для распознавания варианта ФД, в то время как профили гормонов и пептидов желудочно-кишечного тракта могут помочь в его идентификации [19].…”

Section: резюмеunclassified

Infl uence of blood motylin concentration on clinical symptomatics of functional dyspepsy

Shklyaev

Shutova

Казарин

et al. 2022

jour

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Purpose of the study: to clarify the effect of the concentration of motilin in the blood on the clinical symptoms of functional dyspepsia. Materials and methods. A prospective examination of 90 people aged 22,3±0,17 years was carried out, divided into 3 groups: patients with postprandial distress syndrome (PDS), patients with epigastric pain syndrome (EPS), practically healthy. All subjects were questioned according to the GSRS questionnaire, and the concentration of motilin in their blood was determined before and after the drinking test. Statistical processing included the calculation of mean values, their errors, Student’s t-test, Pearson’s correlation test, factor analysis. Results. In patients with PDS, the intensity of abdominal pain (2,47±0,38 points) does not differ from healthy ones (2,19±0,22 points), in patients with EPS it is higher (4,33±0,51 points). Dyspeptic syndrome is more typical for patients with PDS (2,07±0,12 points) than for EPS (1,10±0,04 points). The concentration of motilin in the blood on an empty stomach with PDS (9605,47±167,64 pg/ml) is higher than with EPS (8780,67±232,27 pg/ml). After the drinking test, the level of motilin in the blood of patients with EPS increased to 9367,33±145,78 pg/ml, the PDS decreased to 9323,33±239,04 pg/ml. With PDS, the severity of reflux syndrome directly correlates with the concentration of motilin in the blood. In EPS, the initial level of motilin correlates inversely with the severity of reflux syndrome, constipation syndrome, and the volume of water drunk. After the drinking test, there is an inverse correlation between the level of motilin and the severity of diarrheal and dyspeptic syndromes, and a direct correlation with the intensity of abdominal pain. The initial level of motilin in the blood brings the greatest factor load into the “factor of motor disorders”. Conclusion. The initial level of motilin and its dynamics during water load play an essential role in the formation of the clinical picture of functional dyspepsia.

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Section: резюмеunclassified

Infl uence of blood motylin concentration on clinical symptomatics of functional dyspepsy

Shklyaev

Shutova

Казарин

et al. 2022

jour

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“…Результаты исследований отечественных ученых [6,10] подтверждают, что опросник пищевого поведения DEBQ удовлетворяет критериям валидности и надежности. В обеих группах также были использованы опросник гастроэнтерологических симптомов GSRS, опросник качества жизни SF-36, применение которых обосновано в ряде работ [11,12]. Также измерялся уровень глюкозы натощак и после еды, в I группе пациентов дополнительно определялись частота самостоятельного измерения уровня глюкозы и наличие осложнений диабета.…”

Section: материалы и методыunclassified

Eating Disorders in Patients With Chronic Gastritis and Type 2 Diabetes Mellitus

Казарин

Шкляев

Горбунов

2019

Arhivʺ vnutrennej mediciny

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Diabetes mellitus holds one of the leading positions among the current problems of modern medicine. Despite the obvious success in studying diabetes in the last decades, its prevalence has become pandemic. In spite of the use of modern methods of therapy, a rather high frequency of diabetes mellitus complications from various organs and systems, the pathological changes in which largely determine the course of the disease and patient’s quality of life remains. Issues of eating disorders and their correction play an important role in the complex therapy of patients with diabetes mellitus. Objective: determination of the characteristics and relationship of eating disorders with gastroenterological symptoms and glucose levels in patients with chronic gastritis in type 2 diabetes. Materials and methods: dynamic study of the eating behavior and quality of life in 66 patients with chronic gastritis in type 2 diabetes mellitus was conducted using GSRS, SF-36 and DEBQ questionnaires. The level of glucose on an empty stomach and after eating was also measured, the frequency of self-measurement of glucose level and the presence of diabetes mellitus complications were determined. Results: the identified correlation relationships suggest that gastrointestinal symptoms characteristic of chronic gastritis with type 2 diabetes mellitus worsen the physical and psychological components of health, which provokes a breakdown and a violation of the diet in this category of patients. Conclusion: chronic gastritis in patients with type 2 diabetes mellitus aggravates the prognosis of diabetes and exacerbates eating disorders, which requires observation of an endocrinologist, as well as a gastroenterologist and psychotherapist in the management of such patients.

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Pathogenetic role of cholecystokinin in functional dyspepsia

et al. 2022

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Introduction. The high prevalence of functional dyspepsia in the population requires detailing the mechanisms of its development with the definition of the role of hormones of the gastrointestinal tract in the development of clinical symptoms.Purpose of the study: to clarify the pathogenetic role of cholecystokinin in functional dyspepsia.Materials and methods. A prospective examination of 90 people aged 22.3 ± 0.17 years, divided into 3 groups, was carried out: patients with postprandial distress syndrome (PDS), patients with epigastric pain syndrome (EPS), practically healthy. The participants of the study were questioned according to the GSRS questionnaire, their anthropometric data, the concentration of cholecystokinin in the blood before and after the drinking test were determined. Statistical processing included calculation of means, their errors, Mann-Whitney U-test for independent samples and Wilcoxon W-test for related samples, Spearman’s rank correlation test.Results. Patients with EPS are characterized by a statistically significantly greater severity of abdominal pain syndrome (4.33 ± 0.51 points) than those suffering from PDS (2.47 ± 0.38 points) and healthy people (2.19 ± 0.22 points). Dyspeptic syndrome is more typical for patients with PDS (2.07 ± 0.12 points) than those with EPS (1.10 ± 0.04 points). Patients with PDS are characterized by higher values of height, hip volume, lean mass, waist to hip ratio than patients with EPS. The concentration of cholecystokinin in the blood on an empty stomach in patients with EPS (213.37 ± 14.35 pg/ml) is statistically significantly higher than in those examined with PDS (129.45 ± 10.44 pg/ml) and healthy people (146.99 ± 5.17 pg/ml). The level of cholecystokinin in the blood after water exercise in patients with PDS increased statistically significantly to 176.14 ± 8.16 pg/ml, with EPS – decreased to 187.98 ± 7.26 pg/ml. Correlations between the magnitude of cholecystokininemia and the main anthropometric data in EPS and PDS are multidirectional.Conclusion. Cholecystokinin plays an important role in the pathogenesis of gastroduodenal motility disorders in patients with functional dyspepsia.

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The Use of Specific and Non-Specific Questionnaires to Assess Quality of Life in Patients With Functional Disorders of Intestine

Cited by 5 publications

References 3 publications

Infl uence of blood motylin concentration on clinical symptomatics of functional dyspepsy

Infl uence of blood motylin concentration on clinical symptomatics of functional dyspepsy

Eating Disorders in Patients With Chronic Gastritis and Type 2 Diabetes Mellitus

Pathogenetic role of cholecystokinin in functional dyspepsia

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