The Use of SPECT in a Multidisciplinary Memory Clinic

Pasquier, Florence; Lavenu, Isabelle; Lebert, Florence; Jacob, Bruno; Steinling, M.; Petit, H

doi:10.1159/000106669

Cited by 26 publications

(19 citation statements)

References 20 publications

(29 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The clinical diagnosis may be strongly supported by brain imaging such as regional cerebral blood flow measurement with the xenon inhalation technique [33,34], single-photon emission computerized tomography [35,36] and positron emission tomography. Most often, however, these patients are investigated with CT and MRI [37][38][39] because of the severe deterioration of personality and behavior.…”

Section: Discussionmentioning

confidence: 99%

Magnetic Resonance Imaging and Histopathology in Dementia, Clinically of Frontotemporal Type

Larsson

Passant²,

Sundgren³

et al. 2000

Dement Geriatr Cogn Disord

View full text Add to dashboard Cite

The magnetic resonance imaging (MRI) and computed tomography findings in 28 patients with the clinical diagnosis of frontotemporal dementia (FTD) were compared with the findings in a control group of 76 individuals without dementia or stroke. A pattern of frontal and temporal atrophy with predominantly frontal white matter changes was found in the FTD patients, and this was significantly different from the radiological findings in the control group. Six of the FTD patients have undergone autopsy. Histopathological evaluation showed a primary cortical degenerative disease (frontal lobe degeneration of non-Alzheimer type) in 3 of them, and primary white matter disorder, mainly frontal, of basically ischemic type (selective incomplete white matter infarction) in 3 of them. MRI could be a helpful tool to support the clinical diagnosis FTD, especially in young patients. MRI may also be helpful for the differentiation of a primary neurodegenerative from a mainly ischemic-vascular type of dementia.

show abstract

Section: Discussionmentioning

confidence: 99%

Magnetic Resonance Imaging and Histopathology in Dementia, Clinically of Frontotemporal Type

Larsson

Passant²,

Sundgren³

et al. 2000

Dement Geriatr Cogn Disord

View full text Add to dashboard Cite

show abstract

“…This frontal hypoperfusion predicted the frontal pathology that characterizes FTD. Others confirmed these observations [17][18][19][20][21][22][23], and quantitative studies with positron emission tomography (PET) showed that patients with Pick's disease had diminished frontal lobe glucose uptake suggesting altered neuronal metabolism in the anterior brain regions [24][25][26][27][28]. Yet, despite these elegant clinical and imaging studies which should have allowed accurate diagnosis of FTD, the misdiagnosis rate for this condition has remained high [14].…”

Section: Historical Reviewmentioning

confidence: 99%

Neuroimaging in the Diagnosis of Frontotemporal Dementia

Miller¹,

Gearhart²

1999

Dement Geriatr Cogn Disord

View full text Add to dashboard Cite

The role of neuroimaging for the diagnosis of frontotemporal dementia (FTD) remains controversial. The modern history of imaging in the study of FTD is outlined. Also, the findings on MRI and SPECT in 15 consecutive FTD patients is noted. Both MRI and SPECT detected focal frontal involvement in nearly every single case (MRI 14/15 and SPECT 15/15). Also, the majority of patients showed asymmetry on MRI (8/15) and SPECT (12/15). This study confirms that neuroimaging is sensitive to the frontotemporal degeneration associated with FTD. Additionally, it suggests that this is often asymmetric in the relative involvement of these brain regions.

show abstract

“…Qualitative visual assessment of PET scans can be reliable (intra-observer = 0.56; interobserver = 0.51) [7], as can be SPECT [8,9], particularly if well defined classification criteria are used [10,11].…”

Section: Image Analysis Methodsmentioning

confidence: 99%

Is there Still a Place for Perfusion SPECT in the Diagnosis of Dementia?

Ebmeier

2010

TONMEDJ

View full text Add to dashboard Cite

Abstract:Although research interest within functional imaging has moved towards applications of MRI, such as BOLD and perfusion imaging, there is a wealth of clinical experience in emission tomographic imaging techniques that make the use of these modalities relevant for the decades to come. This review touches upon the technical and practical issues that distinguish SPECT from PET, describes perfusion and metabolic changes observed in the dementias, compares the clinical utility of the two techniques, and reports data on clinical sensitivity and specificity, as well as diagnostic head-to head comparisons in dementia, and specifically Alzheimer's disease. While few centres have a genuine choice between PET and SPECT, either appears to be good enough to help with the differential diagnosis of dementia in difficult cases.

show abstract

The Use of SPECT in a Multidisciplinary Memory Clinic

Cited by 26 publications

References 20 publications

Magnetic Resonance Imaging and Histopathology in Dementia, Clinically of Frontotemporal Type

Magnetic Resonance Imaging and Histopathology in Dementia, Clinically of Frontotemporal Type

Neuroimaging in the Diagnosis of Frontotemporal Dementia

Is there Still a Place for Perfusion SPECT in the Diagnosis of Dementia?

Contact Info

Product

Resources

About