The Use of the Antiarrhythmic Agents in the Elderly

Carbonin, P. U.; Gennaro, Marco Di; Bernabei, Roberto; Cocchi, A; Carosella, Luciana; Pahor, Marco; Taddei, I

doi:10.1007/978-1-4613-2791-2_25

Cited by 2 publications

(2 citation statements)

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“…"This is in agreement with several reports demonstrating an increased sensitivity of the aged myoeardium to situations generating cell calcium overload (1,2,6,7,9). The reduced capacity of the senescent heart to handle the calcium load may be due to alterations in the sarcoplasmic reticulum function repeatedly demonstrated in the ageing myocardium (4).…”

Section: Discussionsupporting

confidence: 90%

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Age-related differences in isolated rat sinus node function

et al. 1987

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In order to rule out age-related differences in the sinus node (SN) function, the effects of different substances were tested in SN isolated preparations from adult (4-5-month-old) and old (24-25-month-old) rats. No difference was seen in the in vivo heart rate between adult and old rats, whereas sinus node rate (SNR) was significantly lower in the old rather than in the adult preparations. The effects of acetylcholine (10(-9)-10(-5) M) were similar between the two groups of preparations. The response to adenosine (10(-9)-10(-4) M) was significantly higher in the adult than in the old preparations (p less than 0.05). No significant difference was noted in the response to isoproterenol (10(-10)-10(-6) M). High calcium (5.4-8.1 mM) caused an increase of the SNR that was significantly greater in the old than in the adult preparations (p less than 0.005). In conclusion, our results show an age-related decrease in the isolated SNR that does not seem to be mediated by different responses to neuromediators but is probably due to an alteration of the intrinsic activity of the SN cells.

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Section: Discussionsupporting

confidence: 90%

“…In fact, the ISO infusion enhances the heart rate more in adults than in older subjects (20,22). Furthermore, a strict correlation exists between ageing and the incidence of sick sinus syndrome (SSS) (1).…”

Section: Introductionmentioning

confidence: 99%