The Use of the Coenzyme Q10 as a Food Supplement in the Management of Fibromyalgia: A Critical Review

Campisi, Luca; Motta, Concettina La

doi:10.3390/antiox11101969

Cited by 7 publications

(3 citation statements)

References 98 publications

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“…For example, supplementation with CoQ10 has shown promise in alleviating symptoms in some PVFS patients. However, further research is crucial to unravel the complexities of this connection, to develop targeted interventions to improve the quality of life for these individuals, and to explore the effectiveness and safety of such interventions [ 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 ]. The rationale for CoQ10 supplementation with regard to mitochondrial hijacking is considered in the following section.…”

Section: Evidence Of Mitochondrial Dysfunction In Post-viral Fatigue ...mentioning

confidence: 99%

Mitochondrial Dysfunction and Coenzyme Q10 Supplementation in Post-Viral Fatigue Syndrome: An Overview

Mantle,

Hargreaves,

Domingo

et al. 2024

IJMS

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Post-viral fatigue syndrome (PVFS) encompasses a wide range of complex neuroimmune disorders of unknown causes characterised by disabling post-exertional fatigue, myalgia and joint pain, cognitive impairments, unrefreshing sleep, autonomic dysfunction, and neuropsychiatric symptoms. It includes myalgic encephalomyelitis, also known as chronic fatigue syndrome (ME/CFS); fibromyalgia (FM); and more recently post-COVID-19 condition (long COVID). To date, there are no definitive clinical case criteria and no FDA-approved pharmacological therapies for PVFS. Given the current lack of effective treatments, there is a need to develop novel therapeutic strategies for these disorders. Mitochondria, the cellular organelles responsible for tissue energy production, have recently garnered attention in research into PVFS due to their crucial role in cellular bioenergetic metabolism in these conditions. The accumulating literature has identified a link between mitochondrial dysfunction and low-grade systemic inflammation in ME/CFS, FM, and long COVID. To address this issue, this article aims to critically review the evidence relating to mitochondrial dysfunction in the pathogenesis of these disorders; in particular, it aims to evaluate the effectiveness of coenzyme Q10 supplementation on chronic fatigue and pain symptoms as a novel therapeutic strategy for the treatment of PVFS.

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Section: Evidence Of Mitochondrial Dysfunction In Post-viral Fatigue ...mentioning

confidence: 99%

Mitochondrial Dysfunction and Coenzyme Q10 Supplementation in Post-Viral Fatigue Syndrome: An Overview

Mantle,

Hargreaves,

Domingo

et al. 2024

IJMS

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“…Animal hearts and livers, which contain 30-200 mg/kg of Co Q10 due to their concentration in high energy-demanding tissues, are the best sources of this bioactive chemical. CoQ10 has no set dietary reference value; nevertheless, the average daily consumption for men and women is 5.4 mg and 3.8 mg, respectively [13]. But as a non-essential nutrient, it is thought to be produced mostly by endogenous synthesis.…”

Section: Psychological Supportmentioning

confidence: 99%

Serum concentrations of Co Q10 and Interleukin-6 in patients with non-segmental Vitiligo

Khammas,

Mikhael,

Abd El-Hassib

et al. 2023

Benha Journal of Applied Sciences

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Background: Vitiligo is a condition where areas of skin lose their pigmentation; oxidative stress and immunological dysregulation have been linked to its development. The purpose of this research was to examine the relationship between Coenzyme Q10 (Co Q10) and in the blood of individuals diagnosed with non-segmental vitiligo. The purpose of this article is to provide readers a thorough introduction to vitiligo, including such topics as the disease's epidemiology, categorization, probable causes, underlying pathogenic processes, diagnostic approaches, and several treatment options. Our goal in compiling this summary is to be a useful tool for clinicians and researchers interested in vitiligo by providing an overview of the current state of knowledge. Conclusions: Because of its complex aetiology, vitiligo is difficult to diagnose and treat. Melanocyte dysfunction is fueled by a complex web of elements including genetic susceptibility, autoimmune processes, oxidative stress, and environmental influences. In order to choose the best course of therapy for vitiligo, the severity and duration of the condition must be evaluated. Treatment for this ailment includes a combination of medicinal, phototherapeutic, and psychosocial approaches. Additional research into the roles of coenzyme Q10 and interleukin-6 in the development of vitiligo is warranted.

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“…CoQ10 has two forms: the oxidized form and the reduced, active form. This reduced form is widely used in the adjunctive treatment of cardiovascular diseases, nutritional health products, and food additives ( 20 ). Notably, CoQ10 plays a key role in myocardial hypoxia, significantly boosting heart health.…”

Section: Introductionmentioning

confidence: 99%

Effect of ubiquinol on cardiorespiratory fitness during high-altitude acclimatization and de-acclimatization in healthy adults: the Shigatse CARdiorespiratory fitness study design

Yang¹,

Ye²,

Liu³

et al. 2023

Front. Cardiovasc. Med.

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Cardiorespiratory function influences exercise capacity and is an important determinant of high-altitude adaptation. Some studies have investigated the characteristics of changes in cardiorespiratory fitness during high-altitude acclimatization. However, studies on changes in cardiorespiratory fitness during high-altitude de-acclimatization are still lacking and have not yet been elucidated. Furthermore, few drugs have been studied to improve cardiorespiratory function during both processes. The Shigatse CARdiorespiratory Fitness (SCARF) study is a single-center, randomized, double-blind, placebo-control clinical trial to explore the effects of ubiquinol on cardiorespiratory fitness during high-altitude acclimatization and de-acclimatization in healthy adults. Participants will be randomly assigned 1:1 to ubiquinol 200 mg daily or a placebo for 14 days before departure until the end of data collection after return in 7 days. Cardiorespiratory fitness is the primary outcome, while acute mountain sickness and high-altitude de-acclimatization symptoms are secondary endpoints. In addition, laboratory measurements, including routine blood tests and serological measurements, will be performed. To the best of our knowledge, the SCARF study will be the first to reveal the changes in the cardiorespiratory fitness characteristics during high-altitude acclimatization and de-acclimatization. Furthermore, the results of this study will contribute to exploring whether ubiquinol supplementation could be beneficial for endurance exercise capacity at different altitudes and help improve adaptation to acute hypoxia and de-acclimatization.Clinical Trial Registration: This study has been registered in the Chinese Clinical Trial Register (www.chictr.org.cn) as ChiCTR2200059900 and ChiCTR2200066328.

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The Use of the Coenzyme Q10 as a Food Supplement in the Management of Fibromyalgia: A Critical Review

Cited by 7 publications

References 98 publications

Mitochondrial Dysfunction and Coenzyme Q10 Supplementation in Post-Viral Fatigue Syndrome: An Overview

Mitochondrial Dysfunction and Coenzyme Q10 Supplementation in Post-Viral Fatigue Syndrome: An Overview

Serum concentrations of Co Q10 and Interleukin-6 in patients with non-segmental Vitiligo

Effect of ubiquinol on cardiorespiratory fitness during high-altitude acclimatization and de-acclimatization in healthy adults: the Shigatse CARdiorespiratory fitness study design

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