The use of the Me<scp>DALL</scp>‐chip to assess IgE sensitization: a new diagnostic tool for allergic disease?

Skrindo, I.; Lupinek, Christian; Valenta, Rudolf; Hovland, Vegard; Pahr, Sandra; Baar, Alexandra; Carlsen, Kai-Håkon; Mowinckel, Petter; Wickman, Magnus; Melén, Erik; Bousquet, Jean; Antó, Josep M.

doi:10.1111/pai.12366

Cited by 52 publications

(56 citation statements)

References 28 publications

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“…MeDALL has already made critical observations concerning IgE biomarkers for the diagnosis and prognosis of allergic diseases (2,60). It is hoped that these projects will help identify biomarkers to enhance personalized medicine (61,62) and to improve patient stratification and clinical trials. Another ongoing EU project, CASyM, has generated a road map for the implementation of systems medicine in clinical research and practice (https://www.casym.eu/).…”

Section: Biomarkers In Respiratory Allergic Diseasesmentioning

confidence: 99%

MACVIA-ARIA Sentinel NetworK for allergic rhinitis (MASK-rhinitis): the new generation guideline implementation

Bousquet

Schünemann

Fonseca

et al. 2015

Allergy

177

172

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Section: Biomarkers In Respiratory Allergic Diseasesmentioning

confidence: 99%

MACVIA-ARIA Sentinel NetworK for allergic rhinitis (MASK-rhinitis): the new generation guideline implementation

Bousquet

Schünemann

Fonseca

et al. 2015

Allergy

177

172

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“…110,179,180 PC structures can enhance fluorescence signals when the optical resonance of the PC surface overlaps with either the excitation or emission spectra of a fluorophore. This enhanced excitation and emission yielded ~7500-fold increase in fluorescence signals.…”

Section: Multi-target Detection Capability For Pc-based Biosensorsmentioning

confidence: 99%

Photonic crystals: emerging biosensors and their promise for point-of-care applications

et al. 2017

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Biosensors are extensively employed for diagnosing a broad array of diseases and disorders in clinical settings worldwide. The implementation of biosensors at the point-of-care (POC), such as at primary clinics or the bedside, faces impediments because they may require highly trained personnel, have long assay times, large sizes, and high instrumental cost. Thus, there exists a need to develop inexpensive, reliable, user-friendly, and compact biosensing systems at the POC. Biosensors incorporated with photonic crystal (PC) structures hold promise to address many of the aforementioned challenges facing the development of new POC diagnostics. Currently, PC-based biosensors have been employed for detecting a variety of biotargets, such as cells, pathogens, proteins, antibodies, and nucleic acids, with high efficiency and selectivity. In this review, we provide a broad overview of PCs by explaining their structures, fabrication techniques, and sensing principles. Furthermore, we discuss recent applications of PC-based biosensors incorporated with emerging technologies, including telemedicine, flexible and wearable sensing, smart materials and metamaterials. Finally, we discuss current challenges associated with existing biosensors, and provide an outlook for PC-based biosensors and their promise at the POC.

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“…Allergen chips are even more sensitive in detecting allergic sensitization than conventional tests based on allergen extract-based skin testing or measurement of IgE reactivity to allergen extracts [156]. Importantly, allergen microarrays allow determination of sensitization to respiratory allergens and the culprit allergen source quickly and hence are ideal first-line tests for the diagnosis of allergic asthma.…”

Section: Outdoor Allergens and Pediatric Asthmamentioning

confidence: 99%

Protein Biomarkers in Asthma

Karaulov

Garib

et al. 2018

Int Arch Allergy Immunol

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Asthma is a chronic disabling respiratory disease that can be triggered by a variety of factors, including allergens, respiratory infections, psychological factors, occupational agents, exercise, atmospheric pollutants, and drugs. The asthma syndrome has been treated for decades according to a “one-fits-all” treatment strategy based on bronchodilators and steroids. With the availability of new forms of treatment targeting the different pathomechanisms of the asthma syndrome, such as anti-immunoglobulin E and cytokine-targeting therapies, the interest in biomarkers that can dis criminate different forms of asthma according to their pathomechanisms has increased. This review attempts to provide an overview of protein biomarkers in asthma and how they might be used to discriminate different forms of asthma that may respond positively to sophisticated new targeted therapies.

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The use of the MeDALL‐chip to assess IgE sensitization: a new diagnostic tool for allergic disease?

Cited by 52 publications

References 28 publications

MACVIA-ARIA Sentinel NetworK for allergic rhinitis (MASK-rhinitis): the new generation guideline implementation

MACVIA-ARIA Sentinel NetworK for allergic rhinitis (MASK-rhinitis): the new generation guideline implementation

Photonic crystals: emerging biosensors and their promise for point-of-care applications

Protein Biomarkers in Asthma

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