The use of the method of transcranial micropolarization to decrease the severity hyperkineses in patients with infantile cerebral palsy

Bogdanov, O. V.; Pinchuk, D. Yu.; Pisar'kova, E. V.; Shelyakin, A. M.; Sirbiladze, Konstantin

doi:10.1007/bf02359800

Cited by 19 publications

(11 citation statements)

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“…Of these, eight published manuscripts were case reports [44, 64–70]. Three publications, one on tDCS [23] and two on TMS [66, 71], did not report the adverse effects of NIBS modalities, nor was the information available from the corresponding authors or ClinicalTrials.gov. The remaining 48 studies addressed the adverse effects of tCS and TMS in more than 513 children and adolescents between 2.5–17.8 years of age (Table 1).…”

Section: Resultsmentioning

confidence: 99%

Safety of Noninvasive Brain Stimulation in Children and Adolescents

et al. 2015

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Background Noninvasive brain stimulation (NIBS) techniques such as transcranial magnetic stimulation (TMS) and transcranial current stimulation (tCS) have the potential to mitigate a variety of symptoms associated with neurological and psychiatric conditions, including stroke, cerebral palsy, autism, depression, and Tourette syndrome. While the safety of these modalities has been established in adults, there is a paucity of research assessing the safety of NIBS among children. Objective To examine the existing literature regarding the safety of NIBS techniques in children and adolescents with neurologic and neuropsychiatric disorders. Methods An electronic search was performed on online databases for studies using NIBS in individuals less than 18 years of age. Non-English publications, diagnostic studies, electroconvulsive therapy, single/dual pulse TMS studies, and reviews were excluded. Adverse events reported in the studies were carefully examined and synthesized to understand the safety and tolerability of NIBS among children and adolescents. Results The data from 48 studies involving more than 513 children/adolescents (2.5–17.8 years of age) indicate that the side-effects of NIBS were, in general, mild and transient [TMS: headache (11.5%), scalp discomfort (2.5%), twitching (1.2%), mood changes (1.2%), fatigue (0.9%), tinnitus (0.6%); tCS: tingling (11.5%), itching (5.8%), redness (4.7%), scalp discomfort (3.1%)] with relatively few serious adverse events. Conclusion Our findings indicate that both repetitive TMS and tCS are safe modalities in children and adolescents with various neurological conditions, especially when safety guidelines are followed. The incidence of adverse events appears to be similar to that observed in adults; however, further studies with longer treatment and follow-up periods are needed to better understand the benefits and tolerance of long-term use of NIBS in children.

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Section: Resultsmentioning

confidence: 99%

Safety of Noninvasive Brain Stimulation in Children and Adolescents

et al. 2015

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“…Despite of excellent tolerability in pediatric populations (Mattai et al, 2011) none of the previous studies have investigated physiological effects of tDCS on the developing brain systematically (Bogdanov et al, 1994;Ilyukhina et al, 2005;Schneider and Hopp, 2011;Siniatchkin et al, 2012;Varga et al, 2011;Yook et al, 2011).…”

Section: Discussionmentioning

confidence: 98%

“…Because of its excellent safety and practicability, tDCS represents a very attractive tool for both, basic science studies of brain function as well as clinical therapeutic application in children and adolescents. However, very few studies have used tDCS in pediatric populations (Bogdanov et al, 1994;Ilyukhina et al, 2005;Schneider and Hopp, 2011;Siniatchkin et al, 2012;Varga et al, 2011;Yook et al, 2011). None of these studies systematically examined the effect of tDCS on the developing brain.…”

Section: Introductionmentioning

confidence: 96%

Stimulation intensities of transcranial direct current stimulation have to be adjusted in children and adolescents

Moliadze

Schmanke

Andreas

et al. 2015

Clinical Neurophysiology

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“…The effects of tDCS on learning and motor performance have been most frequently studied in healthy children (Ciechanski and Kirton, in press). On the other hand, early transcranial polarization studies were conducted to treat patients with infantile cerebral palsy in the 1990s (Bogdanov et al, 1994;Nitsche et al, 2003a). In recent years, most frequently studied pathologies in pediatrics via tDCS include cerebral palsy, refractory epilepsy, autism, deficits of language development, attention-deficit/hyperactivity disorder (ADHD), as well as several other psychiatric disorders (Stagg and Nitsche, 2011;Muszkat et al, 2016).…”

Section: Tdcs In Children and Pediatricsmentioning

confidence: 99%

Applications of transcranial direct current stimulation in children and pediatrics

Rivera-Urbina¹,

Nitsche

Vicario

et al. 2016

Reviews in the Neurosciences

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AbstractTranscranial direct current stimulation (tDCS) is a neuromodulatory noninvasive brain stimulation tool with potential to increase or reduce regional and remote cortical excitability. Numerous studies have shown the ability of this technique to induce neuroplasticity and to modulate cognition and behavior in adults. Clinical studies have also demonstrated the ability of tDCS to induce therapeutic effects in several central nervous system disorders. However, knowledge about its ability to modulate brain functions in children or induce clinical improvements in pediatrics is limited. The objective of this review is to describe relevant data of some recent studies that may help to understand the potential of this technique in children with specific regard to effective and safe treatment of different developmental disorders in pediatrics. Overall, the results show that standard protocols of tDCS are well tolerated by children and have promising clinical effects. Nevertheless, treatment effects seem to be partially heterogeneous, and a case of a seizure in a child with previous history of infantile spasms and diagnosed epilepsy treated with tDCS for spasticity was reported. Further research is needed to determine safety criteria for tDCS use in children and to elucidate the particular neurophysiological changes induced by this neuromodulatory technique when it is applied in the developing brain.

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The use of the method of transcranial micropolarization to decrease the severity hyperkineses in patients with infantile cerebral palsy

Cited by 19 publications

References 1 publication

Safety of Noninvasive Brain Stimulation in Children and Adolescents

Safety of Noninvasive Brain Stimulation in Children and Adolescents

Stimulation intensities of transcranial direct current stimulation have to be adjusted in children and adolescents

Applications of transcranial direct current stimulation in children and pediatrics

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