The use of the PEN3 e-nose in the screening of colorectal cancer and polyps

Altomare, Donato F.; Porcelli, Francesca; Picciariello, Arcangelo; Pinto, Mariangela; Lena, Maria Di; Iambrenghi, Onofrio Caputi; Ugenti, Ippazio; Guglielmi, A.; Vincenti, Leonardo; Gennaro, Gianluigi de

doi:10.1007/s10151-016-1457-z

Cited by 28 publications

(42 citation statements)

References 4 publications

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“…This makes for poor reliability despite some interesting results obtained with dedicated purpose-designed e-noses [9]. In our hands, a commercial e-nose was unable to discriminate patients with CRC or polyps from healthy volunteers [13].…”

mentioning

confidence: 63%

Breath analysis for colorectal cancer screening

Altomare

2016

Colorectal Disease

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mentioning

confidence: 63%

Breath analysis for colorectal cancer screening

Altomare

2016

Colorectal Disease

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“…Conversely, an Italian study using a commercial e-nose (PEN3™ eNose—Airsense Analytics GmbH, Schwerin, Germany), was unable to discriminate between CRC patients and healthy controls despite the higher detection of methane, methane derivatives, organic and aromatic compounds, in CRC patients [ 29 ]. More recently, however, good accuracy was reported using a different eNose (Aeonose™—The eNose Company, Zutphen, the Netherlands) [ 23 ], which showed an AUC of 0.84, with a sensitivity of 95% and specificity of 64%, respectively.…”

Section: Resultsmentioning

confidence: 99%

Are Volatile Organic Compounds Accurate Markers in the Assessment of Colorectal Cancer and Inflammatory Bowel Diseases? A Review

Vernia

Valvano

Fabiani

et al. 2021

Cancers

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Colorectal cancer (CRC) is one of the leading causes of cancer-related death in the Western world. Early detection decreases incidence and mortality. Screening programs based on fecal occult blood testing help identify patients requiring endoscopic examination, but accuracy is far from optimal. Among the alternative strategies, volatile organic compounds (VOCs) represent novel potentially useful biomarkers of colorectal cancer. They also represent a promising tool for the screening of both intestinal inflammation and related CRC. The review is focused on the diagnostic potential of VOCs in sporadic CRC and in inflammatory bowel diseases (IBD), which increase the risk of CRC, analyzing future clinical applications. Despite limitations related to inadequate strength of evidence, differing analytical platforms identify different VOCs, and this unconventional approach for diagnosing colorectal cancer is promising. Some VOC profiles, besides identifying inflammation, seem disease-specific in inflammatory bowel diseases. Thus, breath, urine, and fecal VOCs provide a new and promising clinical approach to differential diagnosis, evaluation of the inflammatory status, and possibly the assessment of treatment efficacy in IBD. Conversely, specific VOC patterns correlating inflammatory bowel disease and cancer risk are still lacking, and studies focused on this issue are strongly encouraged. No prospective studies have assessed the risk of CRC development by using VOCs in samples collected before the onset of disease, both in the general population and in patients with IBD.

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“…At the same time, a reliability assay of commercial electronic nose (PEN3 e-nose) as a screening tool for CRC and polyp patients found that it was impossible to discriminate the tested groups by using supervised or unsupervised statistical methods ( 32 ). They analyzed that the sensor’s unspecific response to the presence of defined exhaled VOC may be the reason for random classification of subjects to each group.…”

Section: Resultsmentioning

confidence: 99%

Volatile Organic Compounds in Human Exhaled Breath to Diagnose Gastrointestinal Cancer: A Meta-Analysis

Xiang

Hua

et al. 2021

Front. Oncol.

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IntroductionHuman exhaled volatile organic compounds (VOCs) are being extensively studied for the purposes of noninvasive cancer diagnoses. This article was primarily to assess the feasibility of utilizing exhaled VOCs analysis for gastrointestinal cancer (GIC) diagnosis.MethodsPRISMA-based system searches were conducted for related studies of exhaled VOCs in GIC diagnosis based on predetermined criteria. Relevant articles on colorectal cancer and gastroesophageal cancer were summarized, and meta analysis was performed on articles providing sensitivity and specificity data.ResultsFrom 2,227 articles, 14 were found to meet inclusion criteria, six of which were on colorectal cancer (CRC) and eight on Gastroesophageal cancer(GEC). Five articles could provide specific data of sensitivity and specificity in GEC, which were used for meta-analysis. The pooled sensitivity, specificity, diagnostic odds ratio (DOR), and area under the curve (AUC) were calculated based on the combination of these data, and were 85.0% [95% confidence interval (CI): 79.0%–90.0%], 89.0% (95%CI: 86.0%–91.0%), 41.30 (21.56–79.10), and 0.93, respectively.ConclusionVOCs can distinguish gastrointestinal cancers from other gastrointestinal diseases, opening up a new avenue for the diagnosis and identification of gastrointestinal cancers, and the analysis of VOCs in exhaled breath has potential clinical application in screening. VOCs are promising tumor biomarkers for GIC diagnosis. Furthermore, limitations like the heterogeneity of diagnostic VOCs between studies should be minded.

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The use of the PEN3 e-nose in the screening of colorectal cancer and polyps

Cited by 28 publications

References 4 publications

Breath analysis for colorectal cancer screening

Breath analysis for colorectal cancer screening

Are Volatile Organic Compounds Accurate Markers in the Assessment of Colorectal Cancer and Inflammatory Bowel Diseases? A Review

Volatile Organic Compounds in Human Exhaled Breath to Diagnose Gastrointestinal Cancer: A Meta-Analysis

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