The use of thiopurines for the treatment of inflammatory bowel diseases in clinical practice

Saibeni, Simone; Virgilio, T.; D’Incà, R.; Spina, Luisa; Bortoli, A.; Paccagnella, Martina; Peli, Marco; Sablich, R.; Meucci, G.; Colombo, Elisabetta; Benedetti, Giuseppe; Girelli, C.M.; Casella, Giovanni; Grasso, Giuseppina; Franchis, Roberto de; Vecchi, Maurizio

doi:10.1016/j.dld.2008.03.016

Cited by 44 publications

(42 citation statements)

References 24 publications

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“…The identified reasons for discontinuation of thiopurine therapy were remission (33%), development of AEs (24%), refractoriness (18%), patient's request (7%), and miscellaneous (1%). 10 Saibeni et al 35 reported a much lower percentage (46%) of thiopurine withdrawal in their IBD cohort. The main reason for discontinuation was AEs (18.3%), followed by patient request in 6.1% of the patients.…”

Section: Discussionmentioning

confidence: 97%

Thiopurine therapy in inflammatory bowel disease patients: Analyses of two 8-year intercept cohorts

Jharap

Seinen

Boer

et al. 2010

Inflammatory Bowel Diseases

185

159

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Azathioprine and 6-mercaptopurine were considered effective in approximately 40% of IBD patients after 5 years of treatment. A quarter of the patients discontinued thiopurines within 3 months, mostly due to adverse events. A high 6-MMP concentration or 6-MMP/6-TGN ratio was associated with therapeutic failure. If thiopurine use was successfully initiated in the first months, its use was usually extended over many years, as long-term use was associated with continuation of therapy.

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Section: Discussionmentioning

confidence: 97%

Thiopurine therapy in inflammatory bowel disease patients: Analyses of two 8-year intercept cohorts

Jharap

Seinen

Boer

et al. 2010

Inflammatory Bowel Diseases

185

159

View full text Add to dashboard Cite

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“…The ra tes of mye lo to xi city (10%), syste mic to xi city (4%), li ver to xi city (1.6%) and pan cre a ti tis (1.6%) ob ser ved in our study do not sig ni fi cantly dif fer from li te ra tu re da ta. 15,17,18 No drug-re la ted mor ta lity was ex pe ri en ced in our se ri es. It was pre vi o usly shown that risk of lymphop ro li fe ra ti ve di sor der was fi ve ti mes hig her in pa ti ents ex po sed to thi o pu ri nes than in tho se ne ver ex po sed to the se drugs, and old age, ma le sex, and lon ger du ra ti on of inf lam ma tory bo wel di se a se we re al so as so ci a ted with in cre a sed risk.…”

Section: Discussionmentioning

confidence: 99%

“…Hig her re mis si on ra tes ob ser ved in our se ri es may be due to the ret ros pec ti ve na tu re of our study and the re la ti vely small si ze of our pa ti ent po pu la ti on com pared to ot her se ri es. 7,[13][14][15] Ad ver se ef fects we re ob ser ved in 16% (19/122) of our pa ti ents and the most fre qu ent ones we re mye lo to xi city in 6.6% (8/122) and syste mic to xi city re por ted in 4% (4/122). Drug dis con ti nu a ti on ra te du e to si de ef fects was 9.8%.…”

Section: Discussionmentioning

confidence: 99%

“…The ove rall ef fi cacy of thi opu ri nes was ob ser ved in two out of three IBD pa ti ents in the pre vi o us re ports which we re per formed in cli ni cal prac ti ce. 7,[13][14][15] In one se ri es, 85% res pon se ra te was ob ser ved but comp le te re mis si on was less than 50%. 16 Our da ta is in ag re e ment with the re sults of ot her stu di es reporting AZA as an effi ci ent drug in the tre at ment of CD and UC.…”

Section: Discussionmentioning

confidence: 99%

“…Anot her di sadvan ta ge is the re la ti vely small si ze of the our pa tient po pu la ti on com pa red to the ot her si mi lar se ri es in the li te ra tu re. 7,[13][14][15][16] Most of our pa ti ents ha ve CD and they we re eva lu a ted by me ans of CDA I. Ho we ver, nu me ro us prob lems exist with the CDA I. Many va ri ab les on the sco re are sub jec ti ve and a lar ge pro por ti on of the sco re de pends on the pa tients' per cep ti on of the di se a se.…”

Section: Discussionmentioning

confidence: 99%

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Efficacy and Safety of Azathioprine Therapy in Turkish Patients with Inflammatory Bowel Disease: A Retrospective Long Term Follow Up Study

Önal¹,

Arhan²,

Özın³

et al. 2011

Turkiye Klinikleri J Med Sci

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A AB BS S T TR RA AC CT T O Ob b j je ec c t ti i v ve e: : Ef fec ti vity and sa fety of azat hi op ri ne in the tre at ment of inf lam ma tory bowel di se a se ha ve be en pro ved and ci ted in many ar tic les. Ob jec ti ve of this study is to eva lu a te the effi cacy and si de ef fects of azat hi op ri ne par ti cu larly in the long term tre at ment and post sur gi cal proph yla xis of Crohn's di se a se in Tur kish pa ti ents with inf lam ma tory bo wel di se a se. M Ma a t te e r ri i a al l a an nd d M Me et t h ho od ds s: : Pa ti ents tre a ted with azat hi op ri ne we re en rol led in this study and the ef ficacy of azat hiop ri ne was as ses sed with Tru e lo ve-Witts and Crohn's Di se a se Ac ti vity In de xes, retrospectively. R Re e --s su ul lt ts s: : A total of 122 pa ti ents tre a ted with azat hi op ri ne with a me di an du ra ti on of 24 months, inc lu ding 109 pa ti ents with Crohn's di se a se and 13 with ul ce ra ti ve co li tis, we re eva lu a ted. Res ponse (comp le te or par ti al re mis si on) was ob ser ved in 106 (98+8, 87%) of 122 pa ti ents. The me di an dura ti on of re mis si on du ring the tre at ment was 21 months. Ad ver se ef fects we re ob ser ved in 16% (19/122) of our pa ti ents and mye lo to xi city was the most fre qu ent ad ver se ef fect seen in 6.6% (8/122) of the patients. Drug dis con ti nu a ti on ra te du e to si de ef fects was 9.8%. Ove rall res pon se (comp le te and par ti al re mis si on)was seen in 38 (36+2, 90.5%) out of 42 pa ti ents that had be en ta king azat hi oprin for mo re than fo ur ye ars with a me di an period of 60 months. The me di an of re mis si on du ra ti on in tho se pa ti ents that had si mi lar si de ef fects was 53 months. Cli ni cal re cur ren ce was se en in six of 31 pa ti ents tre a ted with azat hi op ri ne for post-sur gi cal proph yla xis in a me di an fol low-up of 42 months. C Co on nc c l lu u s si i o on n: : Our study re-af fir med the sa fety and the ef fec ti ve ness of azat hi op ri ne in the treat ment of inf lam ma tory bo wel di se a se, es pe ci ally for post-sur gi cal proph yla xis and the long term tre at ment. K Ke ey y W Wo or rd ds s: : Inf lam ma tory bo wel di se a ses; azat hi op ri ne; ad ver se ef fects Ö ÖZ ZE ET T A Am ma aç ç: : Azatioprinin inf la ma tu ar bağırsak has ta lı ğı (İBH) nın te da vi sin de ki et kin li ği ve gü -ve ni lir li li ği hak kın da der len miş ka nıt lar bu lun mak ta dır. Ça lış ma mı zın ama cı, İBH olan Türk hasta lar da özel lik le de Crohn's has ta lı ğı nın uzun dö nem te da vi si ve cer ra hi son ra sı pro fi lak si si üze ri ne vur gu yap mak üze re ila cın et kin li ği ve yan et ki du ru mu nu or ta ya koy mak tır. G Ge e r re eç ç v ve e Y Yö ön n t te em m l le er r: : Azatioprin te da vi si al mış top lam 122 has ta ge ri ye dö nük de ğer len di ril mek üze re ça -lış ma ya alın mış tır. İla cın et kin li ği ni be lir le me de Tru e lo ve-Witts ve Crohn Has ta lı ğı Ak ti vi te İn-deks le ri kul la nıl mış tır. B Bu ul l g gu u l la ar r: : Top lam 109 Crohn ve 13 ül ...

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Smoking status and response to thiopurines in steroid-dependent inflammatory bowel disease

Domènech¹,

Carrión²,

García‐Planella³

et al. 2011

Inflammatory Bowel Diseases

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The use of thiopurines for the treatment of inflammatory bowel diseases in clinical practice

Cited by 44 publications

References 24 publications

Thiopurine therapy in inflammatory bowel disease patients: Analyses of two 8-year intercept cohorts

Thiopurine therapy in inflammatory bowel disease patients: Analyses of two 8-year intercept cohorts

Efficacy and Safety of Azathioprine Therapy in Turkish Patients with Inflammatory Bowel Disease: A Retrospective Long Term Follow Up Study

Smoking status and response to thiopurines in steroid-dependent inflammatory bowel disease

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