The Use of Traditional Chinese Medicine in Relieving EGFR-TKI-Associated Diarrhea Based on Network Pharmacology and Data Mining

Abstract

In this study, the role of traditional Chinese medicine (TCM) in relieving epidermal growth factor receptor-tyrosine kinase inhibitor- (EGFR-TKI-) associated diarrhea was discussed by network pharmacology and data mining. Prediction of drug targets by introducing the EGFR-TKI molecular structures into the SwissTargetPrediction platform and diarrhea-related targets in the DrugBank, GeneCards, DisGeNET, and OMIM databases were obtained. Compounds in the drug-disease target intersection were screened by absorption, distribution, metabolism, and excretion parameters and Lipinski’s rule in Traditional Chinese Medicine Systems Pharmacology. TCM-containing compounds were selected, and information on the property, taste, and meridian tropism of these TCMs was summarized and analyzed. A target-compound-TCM network diagram was constructed, and core targets, compounds, and TCMs were selected. The core targets and components were docked by AutoDock Vina (Version 1.1.2) to explore the target combinations of related compounds and evaluate the docking activity of related targets and compounds. Twenty-three potential therapeutic TCM targets for the treatment of EGFR-TKI-related diarrhea were obtained. There were 339 compounds acting on potential therapeutic targets, involving a total of 402 TCMs. The results of molecular docking showed good binding between the core targets and compounds, and the binding between the core targets and compounds was similar to that of the core target and the recommended drug loperamide. TCMs have multitarget characteristics and are present in a variety of compounds used for relieving EGFR-TKI-associated diarrhea. Antitumor activity and the efficacy of alleviating diarrhea are the pharmacological basis of combining TCMs with EGFR-TKI in the treatment of non-small-cell lung cancer. The core targets, compounds, and TCMs can provide data to support experimental and clinical studies on the relief of EGFR-TKI-associated diarrhea in the future.

Meta-analysis of TCM in the Treatment of AIDS Diarrhea

“…It can effectively improve TCM syndrome scores, and the adverse reactions are slight. 22 This study further analyzed the publication bias of the included literature, and the results showed that there was a certain bias in the comparison of TCM syndrome scores between the two groups. In view of these results, it is suggested that using different test methods to observe the bias of the unified index in the future will improve the credibility of the literature.…”

Unraveling the Mechanism of Xiaochaihu Granules in Alleviating Yeast-Induced Fever Based on Network Analysis and Experimental Validation

“…The active compounds and their corresponding targets were screened using Traditional Chinese Medicine Systems Pharmacology (TCMSP) ( , accessed on 15 June 2023), SwissADME ( , accessed on 15 June 2023), and SwissTargetPrediction Database ( , accessed on 15 June 2023), following previously reported methods [ 105 ]. The targets of the ingredients were standardized using the UniProt database ( , accessed on 18 June 2023).…”

Network Pharmacology Analysis of the Mechanisms of Compound Herba Sarcandrae (Fufang Zhongjiefeng) Aerosol in Chronic Pharyngitis Treatment

“…Potential target genes of CP were collected from Online Mendelian Inheritance in Man (OMIM) ( https://omim.org/ ), 25 DrugBank Online ( https://www.drugbank.ca/ ), 26 DisGeNT database ( https://www.disgenet.org/ ), 26 and Genetic Association Database (GAD) ( https://geneticassociationdb.nih.gov/ ) 25 with the keyword of “chronic pharyngitis”. The overlapping and repeat targets were excluded.…”