The use of transdermal optical coherence tomography to image the superficial temporal arteries

Mollan, Susan P; Keane, Pearse A.; Denniston, Alastair K

doi:10.1038/eye.2016.206

Cited by 8 publications

(4 citation statements)

References 9 publications

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“…Transdermal OCT has been reported in a series of eight patients [61]; it demonstrated that transdermal OCT identified the superficial temporal artery. The advantages over TAB were reported to be similar to US and it is quick and easy to use.…”

Section: Research In Other Imaging Modalitiesmentioning

confidence: 94%

A new era for giant cell arteritis

Lyons

Quick

Sinclair

et al. 2019

Eye

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The landscape of the investigation and management of giant cell arteritis (GCA) is advancing. In this review we will outline the recent advances by searching the current English literature for relevant articles using key words of giant cell arteritis, temporal arteritis, Horton's disease, investigation, and treatment. Delay in diagnosis, diagnostic uncertainty and glucocorticoid (GC) morbidity are among the highest concerns of clinicians and patients in this disease area. The positive news is that fast track pathways, imaging techniques and new therapies are emerging for routine management of GCA. Future directions for intervention in the treatment paradigm will be discussed.

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Section: Research In Other Imaging Modalitiesmentioning

confidence: 94%

A new era for giant cell arteritis

Lyons

Quick

Sinclair

et al. 2019

Eye

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“…High-resolution (3 up to 7 Tesla) MRI to image the superficial and extracranial arteries in GCA demonstrated arterial wall thickening with peri-adventitial and mural contrast enhancement with sensitivities ranging from 50 to 89% [55]. Other imaging techniques that are being investigated include photoacoustic imaging [56] and optical coherence tomography of the superficial temporal artery [57].…”

Section: Recommendationmentioning

confidence: 99%

European Headache Federation recommendations for neurologists managing giant cell arteritis

et al. 2020

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Background and aim: Giant cell arteritis (GCA) remains a medical emergency because of the risk of sudden irreversible sight loss and rarely stroke along with other complications. Because headache is one of the cardinal symptoms of cranial GCA, neurologists need to be up to date with the advances in investigation and management of this condition. The aim of this document by the European Headache Federation (EHF) is to provide an evidence-based and expert-based recommendations on GCA. Methods: The working group identified relevant questions, performed systematic literature review and assessed the quality of available evidence, and wrote recommendations. Where there was not a high level of evidence, the multidisciplinary (neurology, ophthalmology and rheumatology) group recommended best practice based on their clinical experience. Results: Across Europe, fast track pathways and the utility of advanced imaging techniques are helping to reduce diagnostic delay and uncertainty, with improved clinical outcomes for patients. GCA is treated with high dose glucocorticoids (GC) as a first line agent however long-term GC toxicity is one of the key concerns for clinicians and patients. The first phase 2 and phase 3 randomised controlled trials of Tocilizumab, an IL-6 receptor antagonist, have been published. It is now been approved as the first ever licensed drug to be used in GCA. Conclusion: The present article will outline recent advances made in the diagnosis and management of GCA.

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“…When compared to other modalities such as conventional OCT or even confocal microscopy, FF-OCT was demonstrated to significantly improve spatial resolution by a factor varying from five to ten depending on the acquisition axis [21]. Until now, most groups have focused on the potential role of FF-OCT during oncologic interventions as new routine approach to surgical pathology [22], and, except for one preliminary study in which the superficial temporal arteries were imaged with dermal OCT [23], there has been no reported attempt to employ high definition interference microscopy for the pathological diagnosis of GCA. The present work pursues the hypothesis that FF-OCT could help both the clinician and pathologist to improve TAB performance, and compares, for the first time, FF-OCT and conventional histological examination for the pathological diagnosis of GCA.…”

Section: Introductionmentioning

confidence: 99%

Full-field optical coherence tomography for the diagnosis of giant cell arteritis

Maldiney

Greigert

Martin³

et al. 2020

PLoS ONE

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Histopathological examination of temporal artery biopsy (TAB) remains the gold standard for the diagnosis of giant cell arteritis (GCA) but is associated with essential limitations that emphasize the need for an upgraded pathological process. This study pioneered the use of full-field optical coherence tomography (FF-OCT) for rapid and automated on-site pathological diagnosis of GCA. Sixteen TABs (12 negative and 4 positive for GCA) were selected according to major histopathological criteria of GCA following hematoxylin-eosin-saffronstaining for subsequent acquisition with FF-OCT to compare structural modifications of the artery cell wall and thickness of each tunica. Gabor filtering of FF-OCT images was then used to compute TAB orientation maps and validate a potential automated analysis of TAB sections. FF-OCT allowed both qualitative and quantitative visualization of the main structures of the temporal artery wall, from the internal elastic lamina to the vasa vasorum and red blood cells, unveiling a significant correlation with conventional histology. FF-OCT imaging of GCA TABs revealed destruction of the media with distinct remodeling of the whole arterial wall into a denser reticular fibrous neo-intima, which is distinctive of GCA pathogenesis and accessible through automated Gabor filtering. Rapid on-site FF-OCT TAB acquisition makes it possible to identify some characteristic pathological lesions of GCA within a few minutes, paving the way for potential machine intelligence-based or even non-invasive diagnosis of GCA.

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The use of transdermal optical coherence tomography to image the superficial temporal arteries

Cited by 8 publications

References 9 publications

A new era for giant cell arteritis

A new era for giant cell arteritis

European Headache Federation recommendations for neurologists managing giant cell arteritis

Full-field optical coherence tomography for the diagnosis of giant cell arteritis

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