The Use of Transvaginal Color Flow Imaging After in Vitro Fertilization to Identify Optimum Uterine Conditions Before Embryo Transfer

Steer, C.V.; Campbell, Stuart; Tan, Seang Lin; Crayford, Tim; Mills, C. A.; Mason, Bridgett; Collins, William P.

doi:10.1097/00006254-199206000-00024

Cited by 96 publications

(142 citation statements)

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“…The measurement of impedance to uterine blood flow in IVF cycles has provided an indirect measure of endometrial receptivity (37,38) . Battaglia et al 39 reported the highest pregnancy rate in the group with lower resistance to blood flow in the uterine spi¬ral arteries.…”

Section: Such Finding Coincided With Silverberg Et Almentioning

confidence: 99%

Relation of progesterone and luteinizing hormone serum levels and Ultrasound endometrium criteria with intracytoplasmatic sperm injection outcome

2017

Evidence Based Women's Health Journal

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Background: Hormone levels (progesterone "P" and luteinizing hormone "LH) are vitally important to the proper functioning of the female reproductive cycle and together with Ultrasound assessment of endometrial receptivity may predict success of in vitro fertilization/ intracytoplasmatic sperm injection (IVF/ICSI). Objective: to study the effects of serum P and LH levels together with Ultrasound assessment of endometrial receptivity at the day of human chorionic gonadotrophin administration on fertilization and pregnancy rates. Patients and Methods: Thirty patients age ranged 22-38 years underwent ovarian stimulation using a gonadotrophinreleasing hormone (GnRH) agonist for pituitary down-regulation, and then ovarian hyperstimulation was initiated with highly purified human menopausal gonadotrophin (HMG). Final oocyte maturation was triggered 36 hours after human chorionic gonadotrophin (hCG) injection. On the day of hCG administration (Day 0), serum progesterone, LH levels together with Ultrasound assessment of endometrial receptivity (thickness, morphology and the spiral artery resistance index "RI") were evaluated. Fertilization and pregnancy rates were recorded. Results: There was no significant difference between the pregnant and non pregnant women, in respect to age. The pregnancy rate was not affected by the serum LH level but was only 18.75% in cycles in which serum P was more than 1.2 ng/ml on day 0, which was significantly lower than that in cycles in which serum P was less than 1.2 ng/ml on day 0 (64.28%) (P = 0.001). The fertilization rate was lower in the cycles with higher levels of serum P and/or LH than in cycles in which serum P was less than 1.2 ng/ml and serum LH was normal (51.66 vs. 68.85%). Failed cases had altered endometrium and a higher spiral artery RI (resistance index), meaning lower peri-implantation blood flow. Conclusion: This study concluded that the progesterone levels on the day of hCG administration (Day 0) can affect the success of in vitro fertilization, as higher progesterone levels were associated with lower rates of pregnancy and fertilization. Increase serum P level caused advanced endometrial maturation and impaired endometrial receptivity to embryo implantation. The embryo transfer (ET) in such cases can be canceled and freezing all embryos for future transfer must be considered, to increase acceptance of the endometrium and thus increase the success rate.

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Section: Such Finding Coincided With Silverberg Et Almentioning

confidence: 99%

Relation of progesterone and luteinizing hormone serum levels and Ultrasound endometrium criteria with intracytoplasmatic sperm injection outcome

2017

Evidence Based Women's Health Journal

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“…It has been suggested that Acetylsalicylic acid (low dose aspirin <100 mg/d) may increase the uterine blood flow by inhibiting platelet aggregation and reducing vasoconstriction, possibly leading to a more favourable endometrium for embryo implantation [128]. Aspirin may also suppress the negative effects of prostaglandins on the implantation, such as the induction of uterine contractions or an inflammatory response [129].…”

Section: Place Of Aspirin In Rif -Combined Therapy With Lmwhmentioning

confidence: 99%

Thrombophilia in Assisted Reproductive Technology — Place and Needs of Thromboprophylaxis

Ivanov¹,

Tomov²,

Tsvyatkovska³

et al. 2013

Pregnancy Thrombophilia - The Unsuspected Risk

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“…The measurement of impedance to uterine blood flow in IVF cycles has been suggested to contribute to the evaluation of endometrial receptivity (27,28). The decrease in peripheral impedance in the uterine vascular bed, reflected by a low PI, is a consequence of increased blood flow and tissue perfusion, which may improve uterine receptivity (29). Further studies incorporating Doppler measurements are needed to clarify this point.…”

Section: Student's T-testmentioning

confidence: 99%

Cytokine and nitric oxide concentrations in follicular fluid and blood serum of patients undergoing assisted reproductive treatment: relationship to outcome

Kumbak

Akçin

Attar

et al. 2009

Fertility and Sterility

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Objective:The role of cytokines and nitric oxide (NO) in ovarian folliculogenesis and the development of mature and fertilizable oocytes is controversial. The aim of this study is to determine the concentrations of interleukin (IL)-1β, IL-6, IL-8, IL-12, tumor necrosis factor (TNF)-α and NO in the follicular fluid (FF) and blood serum (S) of patients undergoing assisted reproductive treatment (ART) and to investigate whether these cytokines could be used as a predictive parameter for ART outcome. Material and Methods:A retrospective clinical study was performed at a university hospital including a total of 85 women who underwent ART. FF and serum samples were collected at the time of oocyte retrieval and measured for interleukin (IL)-1β, IL-6, IL-8, IL-12, tumor necrosis factor (TNF)-α by the enzyme-linked immunosorbant assay (ELISA) technique, using commercially available kits and NO by the nitrate/nitrite colorimetric assay. The results were compared between the women who became pregnant and those who did not following ART.Results: No significant difference was found in the FF and blood serum concentrations of the cytokines and NO between pregnant and non-pregnant women. Conclusion: Abstract ÖzetOriginal Investigation 132

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The Use of Transvaginal Color Flow Imaging After in Vitro Fertilization to Identify Optimum Uterine Conditions Before Embryo Transfer

Cited by 96 publications

References 0 publications

Relation of progesterone and luteinizing hormone serum levels and Ultrasound endometrium criteria with intracytoplasmatic sperm injection outcome

Relation of progesterone and luteinizing hormone serum levels and Ultrasound endometrium criteria with intracytoplasmatic sperm injection outcome

Thrombophilia in Assisted Reproductive Technology — Place and Needs of Thromboprophylaxis

Cytokine and nitric oxide concentrations in follicular fluid and blood serum of patients undergoing assisted reproductive treatment: relationship to outcome

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