The use of type 1 collagen scaffold containing stromal cell-derived factor-1 to create a matrix environment conducive to partial-thickness cartilage defects repair

Zhang, Wei; Chen, Jialin; Tao, Jiadong; Jiang, Yangzi; Hu, Caibao; Huang, Lu; Ji, Junfeng; Ouyang, Hong

doi:10.1016/j.biomaterials.2012.10.027

Cited by 130 publications

(113 citation statements)

References 41 publications

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“…However, cartilage tissue engineering systems with either cell type have been shown to be successful in some cases and to different extents in various animal models (Grässel and Anders, 2012). Although large animal models (such as pigs, goats, and horses) may more closely resemble the human system, the herein used rabbit model is one of the well accepted small animal models for evaluation of GF or cell-loaded scaffolds in cartilage defects (Sellers et al, 1997;Sellers et al, 2000;Rudert, 2002;Shao et al, 2006;Holland et al, 2007;Qi et al, 2009;Im and Lee, 2010;Jiang et al, 2010;Tokuhara et al, 2010;Wang et al, 2010;Chen et al, 2011;Qi et al, 2011;Yang et al, 2011;Qi et al, 2012;Zhang et al, 2013). Additional to the choice of an adequate animal model, there are still a number of challenges to be overcome in the search for optimum cartilage repair conditions as e.g., the recognition of the optimal cell source, scaffolds, and GFs.…”

Section: Discussionmentioning

confidence: 99%

Comparative, osteochondral defect repair: Stem cells versus chondrocytes versus Bone Morphogenetic Protein-2, solely or in combination

Reyes

Pec²,

Sánchez³

et al. 2013

eCM

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Full-thickness articular cartilage damage does not resolve spontaneously. Studies with growth factors, implantation of autologous chondrocytes and mesenchymal stem cells have led to variable, to some extent inconsistent, results. This work compares osteochondral knee-defect repair in rabbits upon implantation of a previously described alginate/ (poly(lactic-co-glycolic) acid (PLGA) osteochondral scaffold in distinct conditions. Systems were either in vitro pre-cultured with a small number of allogeneic chondrocytes under fibroblast growth factor (FGF)-2 stimulation or the same amount of allogeneic, marrow derived, mesenchymal stem cells (without any pre-differentiation), or loaded with microsphere-encapsulated bone morphogenetic protein (BMP)-2 within the alginate layer, or holding combinations of one or the other cell type with BMP-2. The experimental limit was 12 weeks, because a foregoing study with this release system had shown a maintained tissue response for at least 24 weeks post-operation. After only 6 weeks, histological analyses revealed newly formed cartilage-like tissue, which resembled the adjacent, normal cartilage in cell as well as BMP-2 treated defects, but cell therapy gave higher histological scores. This advantage evened out until 12 weeks. Combinations of cells and BMP-2 did not result in any additive or synergistic effect. Equally efficient osteochondral defect repair was achieved with chondrocyte, stem cell, and BMP-2 treatment. Expression of collagen X and collagen I, signs of ongoing ossification, were histologically undetectable, and the presence of aggrecan protein indicated cartilage-like tissue. In conclusion, further work should demonstrate whether spatiotemporally controlled, on-site BMP-2 release alone could become a feasible therapeutic approach to repair large osteochondral defects.

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Section: Discussionmentioning

confidence: 99%

Comparative, osteochondral defect repair: Stem cells versus chondrocytes versus Bone Morphogenetic Protein-2, solely or in combination

Reyes

Pec²,

Sánchez³

et al. 2013

eCM

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“…This raises the possibility of repairing entire dental tissues through stimulation of endogenous dental stem and progenitor cells. However, several studies in other organs -exploring the possibility of repairing tissues with the exclusive usage of scaffolds impregnated with chemotactic or growth factors -gave uncertain results, judging by the irregular and fibrotic appearance of the regenerated tissue (Lee et al, 2010;Zhang et al, 2013).…”

Section: Stem Cell-based Regenerative Treatments In Dentistrymentioning

confidence: 99%

Stem cell-based approaches in dentistry

Mitsiadis

Orsini

Jiménez-Rojo

2015

eCM

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Repair of dental pulp and periodontal lesions remains a major clinical challenge. Classical dental treatments require the use of specialised tissue-adapted materials with still questionable efficacy and durability. Stem cell-based therapeutic approaches could offer an attractive alternative in dentistry since they can promise physiologically improved structural and functional outcomes. These therapies necessitate a sufficient number of specific stem cell populations for implantation. Dental mesenchymal stem cells can be easily isolated and are amenable to in vitro expansion while retaining their stemness. In vivo studies realised in small and large animals have evidenced the potential of dental mesenchymal stem cells to promote pulp and periodontal regeneration, but have also underlined new important challenges. The homogeneity of stem cell populations and their quality control, the delivery method, the quality of the regenerated dental tissues and their integration to the host tissue are some of the key challenges. The use of bioactive scaffolds that can elicit effective tissue repair response, through activation and mobilisation of endogenous stem cell populations, constitutes another emerging therapeutic strategy. Finally, the use of stem cells and induced pluripotent cells for the regeneration of entire teeth represents a novel promising alternative to dental implant treatment after tooth loss. In this mini-review, we present the currently applied techniques in restorative dentistry and the various attempts that are made to bridge gaps in knowledge regarding treatment strategies by translating basic stem cell research into the dental practice.

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“…Secondly, the degradation byproducts of Coll are nutrient substance for regulating and directing the cell function. The atelocollagen was used for cartilage regeneration, without problems of immunogenicity or inflammation [39,40]. Third, the Coll scaffold in this research showed slow Fig.…”

Section: Discussionmentioning

confidence: 99%

An anti-inflammatory cell-free collagen/resveratrol scaffold for repairing osteochondral defects in rabbits

et al. 2014

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The use of type 1 collagen scaffold containing stromal cell-derived factor-1 to create a matrix environment conducive to partial-thickness cartilage defects repair

Cited by 130 publications

References 41 publications

Comparative, osteochondral defect repair: Stem cells versus chondrocytes versus Bone Morphogenetic Protein-2, solely or in combination

Comparative, osteochondral defect repair: Stem cells versus chondrocytes versus Bone Morphogenetic Protein-2, solely or in combination

Stem cell-based approaches in dentistry

An anti-inflammatory cell-free collagen/resveratrol scaffold for repairing osteochondral defects in rabbits

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