The use of uterine artery doppler indices for prediction of pre-eclampsia in Port-Harcourt, Nigeria

Okwudire, E. G.; Atalabi, Omolola Mojisola; Ezenwugo, Ugonna Micheal

doi:10.4103/npmj.npmj_54_19

Cited by 7 publications

(2 citation statements)

References 20 publications

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“…Our rate of pre-eclampsia is similar to the 7% rate observed in Nigeria. 14 Eclampsia occurs nowadays in <1 out of 10,000 pregnancies in high-income countries, with its associated maternal mortality being <1%. 1 Our high rate of eclampsia may be explained by the poor follow up of women, exemplified by their usually late booking (Table 1) and the fact that the vast majority had <8 recommended visits, as recommended by WHO in 2016, 15 given that non-severe pre-eclampsia can progress rapidly to severe or to eclampsia, 16 as demonstrated in our survey.…”

Section: Discussionmentioning

confidence: 99%

Pre-eclampsia in a Sub-Saharan African country and maternal-perinatal outcome

2022

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Our comparative cohort study, carried out between 3rd January and 30th April 2020, looked at the maternal and perinatal outcomes associated with pre-eclampsia. Of 2019 booked pregnant women, 141 (7.0%) had pre-eclampsia, and 59.8% of these were severe at admission. Significant adverse maternal outcomes were eclampsia, HELLP (haemolysis, elevated liver enzymes, and low platelets) syndrome, and placental abruption, and significant adverse perinatal outcomes were intra-uterine fetal death, preterm delivery, low birth weight (LBW), neonatal asphyxia and early neonatal death. Close attention needs to be given to women with pre-eclampsia in poor resource circumstances.

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Section: Discussionmentioning

confidence: 99%

Pre-eclampsia in a Sub-Saharan African country and maternal-perinatal outcome

2022

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“…These algorithms utilize multiple maternal risk factors, radiological evaluations such as the uterine artery Doppler pulsatility index, and diverse plasma biomarkers to achieve their intended purpose. [6][7][8][9][10][11][12][13] Despite the rising efficacy of these approaches, the actual predictive models for gestational hypertension are still a source of contention and hence not yet used in routine clinical practice.…”

Section: Introductionmentioning

confidence: 99%

Comparative evaluation of gestosis score vs uterine artery pulsatility index in predicting gestational hypertension: A study protocol

Dahiphale,

Potdar,

Acharya

et al. 2023

F1000Res

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Background: Gestational hypertension and its consequences such as preeclampsia, eclampsia is a leading cause of maternal mortality in India. Multiple risk factors are already known to cause hypertension in pregnancy and with newer advances in the field of medicine, newer risk factors are also being detected which contribute to gestational hypertension. There is need to detect these risk factors so that women who are susceptible to developing hypertension in their pregnancy can be identified at the earliest and monitored and managed accordingly. This study includes two methods, gestosis score which is a newer method, and uterine artery Doppler pulsatility index which is commonly utilized in usually urban centers where ultrasonography facilities are available to look for these risk factors. Objective: The study intends to compare the results of both prediction approaches, the Gestosis score and the Uterine Artery Pulsatility Index in identifying women at risk for gestational hypertension so that these women can be monitored vigilantly for the development of hypertension during their pregnancies and contribute to better management and healthy outcomes of pregnancy. Methods: This study will include 140 pregnant women with gestational ages between 13 to 20 weeks. The gestosis score and mean uterine artery pulsatility index will be calculated. Women with a gestosis score of three or more are deemed at risk for gestational hypertension. Women with mean pulsatility index of 95th percentile or higher are labeled at risk of gestational hypertension. The outcomes of these two methods will be compared to assess which is more effective in predicting developing gestational hypertension. Expected outcome: The study aims to provide insights into the effectiveness of both the Gestosis Score and the Uterine Artery Pulsatility Index in predicting gestational hypertension. The results will contribute to employing better risk assessment in clinical practice and the management of high-risk pregnancies.

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circCRAMP1L is a novel biomarker of preeclampsia risk and may play a role in preeclampsia pathogenesis via regulation of the MSP/RON axis in trophoblasts

Zhang

Yang

Zhang

et al. 2020

BMC Pregnancy Childbirth

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Background Preeclampsia is a severe disease in pregnant women, which is primarily managed by early screening and prevention. Circular RNAs (circRNAs) have increasingly been shown to be important biological regulators involved in numerous diseases. Further, increasing evidence has demonstrated that circRNAs can be used as diagnostic biomarkers. This study was conducted to evaluate the potential of circCRAMP1L, previously identified to be downregulated in preeclampsia, as a novel biomarker for predicting the development of preeclampsia. Methods We measured the expression of circCRAMP1L, which is reportedly relevant to trophoblast physiology, in plasma samples from 64 patients with preeclampsia and 64 age-, gestational age-, and body mass index-matched healthy pregnant women by qRT-PCR. MTT proliferation and transwell invasion assays revealed the biological role of circCRAMP1L in preeclampsia pathogenesis. RNA immunoprecipitation and dual-luciferase reporter assays clarified the mechanism underlying the biological function of circCRAMP1L in TEV-1 cells. Results circCRAMP1L circulating levels were significantly lower in patients with preeclampsia (2.66 ± 0.82, △Ct value) than in healthy pregnant women (3.95 ± 0.67, △Ct value, p < 0.001). The area under the receiver operating characteristic curve for circCRAMP1L was 0.813. Univariate and multivariate analyses identified circCRAMP1L as an independent predictor of preeclampsia. Furthermore, when circCRAMP1L was utilised in combination with its target protein macrophage stimulating protein (MSP), the predictive performance increased, with an area under the receiver operating characteristic curve of 0.928 (95% CI 0.882–0.974), 80.0% sensitivity, and 80.0% specificity. The in vitro results indicated that circCRAMP1L regulates cell proliferation, and invasion via MSP and RON proteins. We investigated the molecular mechanisms of these effects. In vitro, relative to the control group, circCRAMP1L overexpression significantly enhanced cell proliferation; furthermore, trophoblast cell invasion increased proportionally with circCRAMP1L expression. RNA immunoprecipitation and luciferase reporter gene illustrated that circCRAMP1L participated in regulation of trophoblast cell by regulating MSP. Conclusion Reduced plasma levels of circCRAMP1L may be associated with an increased risk of preeclampsia, and circCRAMP1L may be a novel biomarker of preeclampsia risk.

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The use of uterine artery doppler indices for prediction of pre-eclampsia in Port-Harcourt, Nigeria

Cited by 7 publications

References 20 publications

Pre-eclampsia in a Sub-Saharan African country and maternal-perinatal outcome

Pre-eclampsia in a Sub-Saharan African country and maternal-perinatal outcome

Comparative evaluation of gestosis score vs uterine artery pulsatility index in predicting gestational hypertension: A study protocol

circCRAMP1L is a novel biomarker of preeclampsia risk and may play a role in preeclampsia pathogenesis via regulation of the MSP/RON axis in trophoblasts

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