This study examines the framing effect on online consumer purchase intention. Three framing effect moderators-warning type (text-based/picturebased), brand familiarity (familiar/unfamiliar), and product type (utilitarian/hedonic)-were considered. The results demonstrated that a positive frame message could create more favorable preferences toward the product than a negative frame message could. Further, consumers with text-based warnings who received positive framing messages had higher purchase intentions toward the target product than did those receiving negative framing messages. However, the online framing effect was not significant for consumers receiving picture-based warnings. Moreover, the online framing effect was significant for consumers familiar with the brand. Finally, positive messages resulted in higher purchase intention for hedonic rather than utilitarian products. This study further examined gender differences in framing effects and found women exhibited greater framing effects than men under the negative frame. The findings provide guidance for designing appropriate product strategy to induce online consumer purchase intentions that favor online retailers.