Background. When exposed to cold in individuals, depending on the individual typological features of the EEG rhythm, various neurophysiological mechanisms of mobilization of functional systems are activated. The purpose of this study is to evaluate the effect of short-term general cooling on the stress resistance of the body and the bioelectrical activity of the occipital and parietal regions of the brain. Material and methods. The analysis of stress resistance and bioelectrical activity of the occipital and parietal regions of the brain in males aged 20 to 23 years after a short-term general cooling was carried out. Results. The cryotherapy procedure increased the stress resistance of the subjects, which persisted for 15 days after its termination. By the end of cold exposure, there is an increase in the bioelectrical activity of the brain in the parietal region, most pronounced for the amplitudes of β1- and θ-rhythms, and 15 days after the cessation of short-term general cooling, an increase in θ-, δ1-activity is noted. Changes in the electroencephalogram of the occipital region after exposure to cold were characterized by an increase in the amplitude of δ1- and β1-rhythms, and this trend persisted 15 days after the course of cryotherapy. In the subjects under study, interhemispheric asymmetry is noted, manifested by a more pronounced value of the amplitudes in the left hemisphere along δ1-, δ2-rhythms, and in the right hemisphere along β1 and θ-rhythms. Conclusions. The increase in the adaptive resource of the subjects caused by the influence of this factor is obviously associated with the identified changes in the bioelectrical activity of the brain in the occipital and parietal regions.