The use of whole genome copy number variation (CNV) to measure genomic instability in mCRPC CTCs.

Abstract

Frozen pathology has a high concordance rate with FP. Precise diagnosis by intraoperative FS is an effective method to guide resection strategy for peripheral small-sized lung adenocarcinoma.

Joint use of the radiomics method and frozen sections should be considered in the prediction of the final classification of peripheral lung adenocarcinoma manifesting as ground-glass nodules

“…The progression of GGNs from AAH, AIS and MIA to IAC is a continuous and dynamic process accompanied by the increment of malignancy [10]. The intraoperative classification of early lung adenocarcinoma is of great significance in determining surgical strategy [11]. FS currently plays a main role in the intraoperative diagnosis and classification of early lung adenocarcinoma, guiding the surgery treatment.…”

“…However, the classification accuracy of FS is unsatisfactory, and for some cases, it cannot give timely pathological classification due to the poor quality or sampling problems (FS deferrals), [12][13][14][15]. This may lead to an inappropriate surgical strategy and even a second surgery for patients [11,14,15].…”

Clinical outcomes of patients with metachronous second primary lung adenocarcinomas

“…Multivariate analysis did not identify sublobar resection of the primary or second tumor as a significantly negative prognostic factor. In our series, most (43/58, 74.1%) of the sublobar resections of the second adenocarcinomas were performed after the new classification, which might be responsible for this nonsignificant difference between lobar and sublobar resections in that the new classification could provide an effective approach to guide the resection strategy for primary adenocarcinoma 13. However, considering that most of the patients with second lesions in this study underwent anatomic lobar resections rather than limited resections before 2011, and many patients in the low-risk subgroup who underwent sublobar resections had the very short duration of follow-up, thus the long-term prognosis for limited resections of second adenocarcinomas based on the new classification is remained unclear.…”

“…Adenocarcinoma has high morphologic heterogeneity, and the new adenocarcinoma classification proposed by the IASLC/ATS/ERS provided precise preoperative12 or intraoperative diagnoses,13 and appropriate extent of resection for various early-stage adenocarcinomas 13,14. There is mounting evidence showing that different histomorphologic patterns in lung adenocarcinomas can be used to define prognostically variable subsets, and differentiating between low- and high-risk lung adenocarcinomas are of high clinical importance in the management of early-stage lung adenocarcinomas 8,15–17.…”

What we know about surgical therapy in early-stage non-small-cell lung cancer: a guide for the medical oncologist

“…The incidence of N1 and N2 nodal involvement in peripheral clinical stage I NSCLC ≤2 cm in diameter was 5.3% and 6.6%, respectively. In tumors <1 cm in diameter, N2 disease was still present in 3.8% of them 14. In the meta-analysis done by Cao et al, it was shown that hilar and mediastinal lymph-node sampling or dissection was more likely to accompany segmentectomies than wedge resections 8.…”