International trade is continuously rising, leading to an increase in the flow of goods passing through transportation hubs, including air and sea. In addition, the aging fleet of inland vessels necessitates renewal through the construction of new vessels, presenting opportunities for the adoption of modern transport technologies. Autonomous barges can transport bulk and containerized cargo between the central port of a specific region and smaller satellite ports, enabling the dispersal of goods over a wider area. Equipping autonomous barges with advanced sensors, such as LIDAR, computer vision systems that operate in visible light and thermal infrared, and incorporating advanced path finding and cooperation algorithms may enable them to operate autonomously, subject only to remote supervision. The purpose of this study is to explore the potential of autonomous electric propulsion barges in inland waterway transport. Given the increasing demand for efficient and sustainable transport solutions as a result of various new policies, which have set new ambitious goals in clean transportation, this study aims to develop a proposition of an electric propulsion hybrid drive inland waterway barge, and compare it to a conventional diesel-powered barge. The methodology involves the creation of a simulation model of an inland waterway class IV electric barge, equipped with advanced sensors and autonomous control systems. The barge’s navigation is managed through a multi-agent system, with evolutionary algorithms determining a safe passage route. This research also utilizes a proprietary networked ship traffic simulator, based on real inland vessel recorded routes, to conduct the autonomous navigation study. The energy consumption of the barge on a route resulting from the ship traffic simulation is then examined using the mathematical model using the OpenModelica package. As a result of the study, the proposed hybrid propulsion system achieved a 16% reduction in fuel consumption and CO2 emissions, while cutting engine operation time by more than 71%. The findings could provide valuable insights into the feasibility and efficiency of autonomous electric propulsion barges, potentially helping future developments in inland waterway transport.