THE USE OP Tc-99m-METH0XY ISOBUTYL ISONITRILE (MIBI) IN EVALUATION OF PATIENTS WITH PRIMARY CARCINOMA OF THE BREAST: COMPARISON WITH Tl-201 (Tl)

Ashok, G.; Kooba, A; Yadegar, J.; Scoy-Mosher, M Van; Ramanna, Lalitha; Silberman, Allan W.; Rosen, Gerald

doi:10.1097/00003072-199209000-00032

Cited by 2 publications

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“…TLC demonstrated that 125 I-Rh is very stable as <4% of free radioiodide was formed and no breakdown products were observed. The diagnostic potential of 131 I-Rh 123 was then tested in nude mice bearing subcutaneous tumors of human origin, namely, the epidermoid carcinoma KB, and the results were compared with those obtained after the intravenous administration of 99m Tc-MIBI, a radiopharmaceutical that is currently used in the clinic in the scintigraphic detection of myocardial disease, certain tumors, and other lesions. − To this end, dynamic images were collected over 1 h, and the cumulated data were analyzed for tumor localization. However, neither 131 I-Rh nor 99m Tc-MIBI was able to image these lesions in tumor-bearing mice (Figure ).…”

Section: Resultsmentioning

confidence: 99%

“…We describe, herein, the synthesis and characterization of nonradioactive I-Rh 123 and its cellular localization in vitro and the no-carrier-added synthesis of 125 I-Rh 123 and its biodistribution in athymic mice bearing human tumor xenografts. In addition, we have compared the in vivo data with that obtained after the administration of hexakis(2-methoxyisobutylisonitrile)technetium(I) ( 99m Tc-MIBI), an agent that is currently used in the clinic to image myocardial disease and certain tumors. − 99m Tc-MIBI had been previously reported by Piwnica-Worms et al to accumulate, as demonstrated by scintigraphy, in one of the animal tumors used in our studies …”

Section: Introductionmentioning

confidence: 95%

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[¹²⁵I/¹²⁷I/¹³¹I]Iodorhodamine: Synthesis, Cellular Localization, and Biodistribution in Athymic Mice Bearing Human Tumor Xenografts and Comparison with [^99mTc]Hexakis(2-methoxyisobutylisonitrile)

et al. 1998

J. Med. Chem.

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The synthesis of halogenated rhodamine (Rh) derivatives was carried out by controlling the stoichiometry of the halogenating agents, bromine and iodine monochloride. In the no-carrier-added synthesis of radioiodinated rhodamine 123, direct labeling of rhodamine 123 (Rh 123) with Na125I/Na131I required the presence of the oxidant peracetic acid. 125I/131I-Rh 123 was synthesized in modest yields (40-45%). HPLC purification separated Rh 123 from its mono- and diiodo derivatives. Monohalogenation of Rh 123 did not alter the compound's ability to permeate viable cells and localize in mitochondria. 125I/131I-Rh 123 was stable in serum in vitro but rapidly metabolized after intravenous injection into mice. Consequently, scintigraphy and biodistribution data reveal poor targeting of subcutaneously growing human tumor xenografts. The results are compared to those obtained following the administration of [99mTc]hexakis(2-methoxyisobutylisonitrile) which also did not image human tumor xenografts in nude mice.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

[¹²⁵I/¹²⁷I/¹³¹I]Iodorhodamine: Synthesis, Cellular Localization, and Biodistribution in Athymic Mice Bearing Human Tumor Xenografts and Comparison with [^99mTc]Hexakis(2-methoxyisobutylisonitrile)

et al. 1998

J. Med. Chem.

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The use of thallium-201 in the preoperative detection of breast cancer: an adjunct to mammography and ultrasonography

et al. 1995

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Thallium-201 breast scans were performed preoperatively in 72 female patients with breast abnormalities detected by mammography and/or ultrasonography (7.5-13 MHz), in order to differentiate benign from malignant breast disease. Informed consent was obtained from each patient. Scintigraphy consisted of anterior and oblique planar images of the affected breast and axilla at 10 min and 3 h following the injection of 201Tl chloride (110 MBq). All 201Tl scans were interpreted without prior knowledge of surgery data. Pathological features of breast malignancies, such as tumour size, axillary lymph node metastases, tumour grading, lymphatic vascular channel invasion and receptor status, were analysed for their association with 201Tl uptake by tumour cells. A total of 76 breast lesions were assessed in the study. On final histological diagnosis, there were 56 malignant tumours, 14 benign nodules (9 fibroadenomas, two cases of adenosis, two cases of focal fibrosis and one case of epitheliosis) and six atypical lesions (atypical ductal or lobular hyperplasia). Thallium scintigraphy was shown to have high accuracy (92%) in detecting breast cancer, better than mammography (74%) and ultrasonography (84%). Almost all (51/56) breast cancers showed greater 201Tl activity than surrounding normal breast tissue while there was no significant increase in 201Tl activity above background in all but one (19/20) case of non-malignant disease. 201Tl activity within breast tumours, calculated as tumour/background (T/B) ratio, ranged between 1.2 and 2.5 with a mean value of 1.45. In our experience the concentration of thallium in the breast cancer seems to be primarily dependent on vascularity and tumour size rather than tumour grading, lymphatic/vascular invasion or receptor status. 201Tl scan sensitivity was 97% for malignant lesions larger than 1.5 cm (n = 35) and 80% for lesions of 1.5 cm or less (n = 21); however, five of the eight breast cancers smaller than 1.0 cm were also detectable by 201Tl scintigraphy, compared with five out of seven by mammography. Thallium scintigraphy would not be useful in evaluating the axilla for lymph node metastases (sensitivity 27%, specificity 77%).

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THE USE OP Tc-99m-METH0XY ISOBUTYL ISONITRILE (MIBI) IN EVALUATION OF PATIENTS WITH PRIMARY CARCINOMA OF THE BREAST: COMPARISON WITH Tl-201 (Tl)

Cited by 2 publications

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[¹²⁵I/¹²⁷I/¹³¹I]Iodorhodamine: Synthesis, Cellular Localization, and Biodistribution in Athymic Mice Bearing Human Tumor Xenografts and Comparison with [^99mTc]Hexakis(2-methoxyisobutylisonitrile)

[¹²⁵I/¹²⁷I/¹³¹I]Iodorhodamine: Synthesis, Cellular Localization, and Biodistribution in Athymic Mice Bearing Human Tumor Xenografts and Comparison with [^99mTc]Hexakis(2-methoxyisobutylisonitrile)

The use of thallium-201 in the preoperative detection of breast cancer: an adjunct to mammography and ultrasonography

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THE USE OP Tc-99m-METH0XY ISOBUTYL ISONITRILE (MIBI) IN EVALUATION OF PATIENTS WITH PRIMARY CARCINOMA OF THE BREAST: COMPARISON WITH Tl-201 (Tl)

Cited by 2 publications

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[125I/127I/131I]Iodorhodamine: Synthesis, Cellular Localization, and Biodistribution in Athymic Mice Bearing Human Tumor Xenografts and Comparison with [99mTc]Hexakis(2-methoxyisobutylisonitrile)

[125I/127I/131I]Iodorhodamine: Synthesis, Cellular Localization, and Biodistribution in Athymic Mice Bearing Human Tumor Xenografts and Comparison with [99mTc]Hexakis(2-methoxyisobutylisonitrile)

The use of thallium-201 in the preoperative detection of breast cancer: an adjunct to mammography and ultrasonography

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[¹²⁵I/¹²⁷I/¹³¹I]Iodorhodamine: Synthesis, Cellular Localization, and Biodistribution in Athymic Mice Bearing Human Tumor Xenografts and Comparison with [^99mTc]Hexakis(2-methoxyisobutylisonitrile)

[¹²⁵I/¹²⁷I/¹³¹I]Iodorhodamine: Synthesis, Cellular Localization, and Biodistribution in Athymic Mice Bearing Human Tumor Xenografts and Comparison with [^99mTc]Hexakis(2-methoxyisobutylisonitrile)