The Usefulness of 111in-Labeled Platelet Scintigraphy in the Diagnosis of Patients With Febrile Syndrome and a Nonfunctioning Renal Graft

Jv, Torregrosa; Bassa, P.; Fj, Lomeña; Jm, Campistol; F, Oppenheimer; Almirall, J; Muxí, África; Andreu, Javier; Setoain, J

doi:10.1097/00007890-199406270-00008

Cited by 4 publications

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“…Fever was the constant clinical feature in all the patients, followed by graft pain and hematuria. The diagnosis was confirmed in the majority of our patients by positive uptake on 11 1In-labeled platelet scintigraphy [22]. The scan was negative in three patients, because they had received steroids shortly before the test was performed.…”

Section: Discussionsupporting

confidence: 60%

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Percutaneous renal artery embolisation of non-functioning renal allografts with clinical intolerance

Cofan

Real²,

Vilardell

et al. 2002

Transplant Int

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The aim of the study was to evaluate the efficacy and safety of percutaneous renal artery embolisation of non-functioning renal allografts in patients with graft intolerance syndrome (GIS). Transcatheter artery embolisation was performed in 30 kidney transplant recipients with CIS. The duration of graft function had been 60 i 45 months. Infectious disease was ruled out in all patients. Embolisation consisted of the injection of polyvinyl alcohol microspheres followed by the insertion of a stainless steel coil in the renal artery branches. Symptoms of CIS included: fever-graft pain (44%, n = 13), fever-hematuria-pain (20%, n = 6), fever-hematuria (1 3 %, n = 4) and fever alone (23%, n= 7). Latency time between graft failure and embolisation was 184 i 227 (17-1181) days. Embolisation was clinically successful with the prolonged disappearance of CIS in 24 patients (80%). Six patients showed initial clinical improvement, but GIS reappeared at 40 * 18 days, and graft nephrectomy was required. There were no major complications associated with embolisation and no deaths. Perirenal collateral supply was a risk factor for the reappearance of CIS. Renal vascular embolisation is a simple, safe and effective technique for treating renal allograft intolerance syndrome and could be a feasible alternative for the first-line treatment.

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Section: Discussionsupporting

confidence: 60%

“…Abdominal ultrasonography was performed to rule out hydronephrosis or renal allograft abscess. A 11 1In-labeled platelet scintigraphy study was used to confirm the diagnosis [22]. All patients were symptomatic at the time of the embolisation.…”

Section: Introductionmentioning

confidence: 99%

Percutaneous renal artery embolisation of non-functioning renal allografts with clinical intolerance

Cofan

Real²,

Vilardell

et al. 2002

Transplant Int

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The influence of vascular diathesis on the localization of inflammatory foci in renal allografts with a specific antigranulocyte antibody

et al. 1996

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Immunoscintigraphy with technetium-99m labelled BW 250/183, a murine monoclonal antibody specific for granulocytes, yielded a false-positive result in a patient suspected of having an abscess in his renal graft. To substantiate the presumption that diathesis and unspecific accumulation of the antibody may have caused this result, ten selected patients were investigated who presented with chronic vascular graft rejection but without signs of bacterial infection. Scintiscans were recorded 4 and 24h after administration of 99mTc-labelled BW 250/183. Graft-background ratios (GBRs) were calculated for each transplant. These were compared with the mean of physiological kidney-background ratios (KBRs) and with bone marrow-background ratios (BMBRs). After removal, the grafts were examined with pathological and immunohistological methods. Seven transplants demonstrated 4-h GBRs (mean: 3.9+/-1.1, P <0.001) significantly outside the range of normal KBRs while three were within the normal range (mean: 1.8+/-0.4). The relation between 4-h and 24-h GBRs varied. After 24h five GBRs still remained increased (mean: 3.2+/-1.4, P <0.05). By contrast the BMBRs decreased uniformly by 18%+/-5%. After graft removal, histopathology demonstrated no dominant granulocyte accumulations but various degrees of chronic vascular and tubulo-interstitial rejection. Immunohistochemical studies did not indicate cross-reactivity of BW 250/183. Increased GBRs of long-standing renal allografts indicate the passage of the antibody through injured vascular walls rather than the presence of granulocyte accumulations. Therefore, variability of GBRs with time reflects changes in transitory concentrations of 99mTc-labelled BW 250/183 in the tissues.

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Percutaneous renal artery embolisation of non-functioning renal allografts with clinical intolerance

Cofan

Real²,

Vilardell

et al. 2002

Transplant International

Self Cite

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The aim of the study was to evaluate the efficacy and safety of percutaneous renal artery embolisation of non-functioning renal allografts in patients with graft intolerance syndrome (GIS). Transcatheter artery embolisation was performed in 30 kidney transplant recipients with GIS. The duration of graft function had been 60+/-45 months. Infectious disease was ruled out in all patients. Embolisation consisted of the injection of polyvinyl alcohol microspheres followed by the insertion of a stainless steel coil in the renal artery branches. Symptoms of GIS included: fever-graft pain (44%, n=13), fever-hematuria-pain (20%, n=6), fever-hematuria (13%, n=4) and fever alone (23%, n=7). Latency time between graft failure and embolisation was 184+/-227 (17-1181) days. Embolisation was clinically successful with the prolonged disappearance of GIS in 24 patients (80%). Six patients showed initial clinical improvement, but GIS reappeared at 40+/-18 days, and graft nephrectomy was required. There were no major complications associated with embolisation and no deaths. Perirenal collateral supply was a risk factor for the reappearance of GIS. Renal vascular embolisation is a simple, safe and effective technique for treating renal allograft intolerance syndrome and could be a feasible alternative for the first-line treatment.

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The Usefulness of 111in-Labeled Platelet Scintigraphy in the Diagnosis of Patients With Febrile Syndrome and a Nonfunctioning Renal Graft

Cited by 4 publications

References 0 publications

Percutaneous renal artery embolisation of non-functioning renal allografts with clinical intolerance

Percutaneous renal artery embolisation of non-functioning renal allografts with clinical intolerance

The influence of vascular diathesis on the localization of inflammatory foci in renal allografts with a specific antigranulocyte antibody

Percutaneous renal artery embolisation of non-functioning renal allografts with clinical intolerance

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