The usefulness of CEA and/or CA19-9 in monitoring for recurrence in gastric cancer patients: a prospective clinical study

Takahashi, Yutaka; Takeuchi, Toshihisa; Sakamoto, Junichi; Touge, Tetsuya; Mai, Masayoshi; Ohkura, H; Kodaira, Susumu; Okajima, Kunio; Nakazato, Hiroaki

doi:10.1007/s10120-003-0240-9

Cited by 138 publications

(129 citation statements)

References 7 publications

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“…When metastasis and recurrence occurred, the CEA, CA19-9, CA24-2, SCC, and CA72-4 levels increased again in compared with postoperative concentrations. Our findings are similar to those of Takahashi et al (2003) who reported that in most patients with high preoperative TMs levels, these TMs increased again at recurrence or metastasis. The finding indicated that patients, who with high preoperative tumor markers levels, and/or at stage II/III/ IV need comprehensive treatment.…”

Section: 10267 Tumor Markers For Diagnosis Monitoring Of Recurrencesupporting

confidence: 92%

Tumor Markers for Diagnosis, Monitoring of Recurrence and Prognosis in Patients with Upper Gastrointestinal Tract Cancer

Jing

Wang²,

Xu³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Section: 10267 Tumor Markers For Diagnosis Monitoring Of Recurrencesupporting

confidence: 92%

Tumor Markers for Diagnosis, Monitoring of Recurrence and Prognosis in Patients with Upper Gastrointestinal Tract Cancer

Jing

Wang²,

Xu³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…Baseline tumor marker levels are thought to provide prognostic information [18]. In gastric cancer, the levels of CEA and CA19-9 are widely used to predict prognosis and recurrence [4,5,19], but the clinical significance of these tumor markers remains unclear in terms of decision-making in the treatment of peritoneal metastasis. Previous reports have shown that the positivities of CA125 and CA72-4 were lower than those of CEA and CA19-9 in all stages of gastric cancer, but the sensitivities of CA125 and CA72-4 were relatively high in the advanced stages [19].…”

Section: Discussionmentioning

confidence: 99%

“…Computed tomography (CT) is commonly utilized to evaluate response in metastatic gastric cancer, and tumor markers, including carcinoembryonic antigen (CEA) and carbohydrate antigen (CA) , are also taken into account as supplementary evidence of response [4,5]. However, in patients with peritoneal metastases, tumor markers are often the only tool with which to evaluate the response to chemotherapy, because individual peritoneal lesions are usually too small to be measured accurately by using CT scans.…”

Section: Introductionmentioning

confidence: 99%

Clinical significance of CA125 and CA72-4 in gastric cancer with peritoneal dissemination

et al. 2011

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Background Serum tumor markers have been shown to correlate with the clinical status of patients with advanced gastric cancer. However, the clinical significance of each tumor marker in patients with peritoneal dissemination has not been fully verified. Methods Four serum markers, carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 19-9, CA125, and CA72-4, were periodically measured in 102 patients with peritoneal dissemination who received combination intravenous and intraperitoneal chemotherapy. The initial values at diagnosis and after treatment were analyzed in association with clinicopathological factors, response to chemotherapy, and overall survival. Results The sensitivities of CEA, CA19-9, CA125, and CA72-4 for peritoneal metastasis at the initial diagnosis were 19, 36, 46, and 45%, respectively. The CA125 level was significantly correlated with the degree of peritoneal dissemination and the existence of malignant ascites. Patients with ovarian metastasis showed significantly higher levels of CA72-4. The median survival time of patients with an elevated CA125 level was significantly shorter than that of patients with a normal CA125 level (36.7 vs. 16.6 months, p \ 0.001). Multivariate analysis showed that the degree of peritoneal metastasis and an elevated CA125 level were independent prognostic factors. Normalization of the CA125 level after 3 courses of chemotherapy was correlated with reduced ascites and improved survival.Conclusions Serum CA125 and CA72-4 are clinically useful markers in diagnosis, evaluating the efficacy of chemotherapy, and predicting the prognosis of patients with peritoneal dissemination. From an academic point of view, periodic measurements of these markers are warranted in gastric cancer patients with possible peritoneal dissemination.

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“…Among these three markers, preoperative elevated CA72-4 was an independent risk factor for reduced patient survival in a multivariate analysis when co-analyzed with CEA and CA19-9 [63]. Takahashi et al [38] reported that the CEA levels and/or CA19-9 levels increased for the first time at recurrence (54.7 and 40.0 %, respectively). Sensitivities for CEA and CA19-9, and combinations of the two markers, for indicating recurrence were 65.8, 55.0, and 85.0 % [38].…”

Section: Ca72-4mentioning

confidence: 99%

“…Takahashi et al [38] reported that the CEA levels and/or CA19-9 levels increased for the first time at recurrence (54.7 and 40.0 %, respectively). Sensitivities for CEA and CA19-9, and combinations of the two markers, for indicating recurrence were 65.8, 55.0, and 85.0 % [38]. More than 90 % of patients with elevated preoperative levels of CEA had increased CEA levels again at the time of recurrence.…”

Section: Ca72-4mentioning

confidence: 99%

Clinical significance of serum tumor markers for gastric cancer: a systematic review of literature by the Task Force of the Japanese Gastric Cancer Association

et al. 2013

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The aim of this review was to evaluate the clinical significance of serum tumor markers, particularly CEA, CA19-9, and CA72-4, in patients with gastric cancer. A systematic literature search was performed using PubMed/MEDLINE with the keywords ''gastric cancer'' and ''tumor marker,'' to select 4,925 relevant reports published before the end of November 2012. A total of 187 publications contained data for CEA and CA19-9, and 19 publications contained data related to all three tumor markers. The positive rates were 21.1 % for CEA, 27.8 % for CA19-9, and 30.0 % for CA72-4. These three markers were significantly associated with tumor stage and patient survival. Serum markers are not useful for early cancer, but they are useful for detecting recurrence and distant metastasis, predicting patient survival, and monitoring after surgery.

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The usefulness of CEA and/or CA19-9 in monitoring for recurrence in gastric cancer patients: a prospective clinical study

Cited by 138 publications

References 7 publications

Tumor Markers for Diagnosis, Monitoring of Recurrence and Prognosis in Patients with Upper Gastrointestinal Tract Cancer

Tumor Markers for Diagnosis, Monitoring of Recurrence and Prognosis in Patients with Upper Gastrointestinal Tract Cancer

Clinical significance of CA125 and CA72-4 in gastric cancer with peritoneal dissemination

Clinical significance of serum tumor markers for gastric cancer: a systematic review of literature by the Task Force of the Japanese Gastric Cancer Association

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