The usefulness of chelation therapy for the remission of symptoms caused by previous treatment with mercury-containing pharmaceuticals: a case report

Corsello, Serafina; Fulgenzi, Alessandro; Vietti, Daniele; Ferrero, Maria Elena

doi:10.1186/1757-1626-2-199

Cited by 21 publications

(18 citation statements)

References 11 publications

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“…In our experience, as shown in previous studies and in the present, removal of toxic metals has induced beneficial effects by improving patient symptoms [29, 33, 34]. No adverse effects were observed from EDTA treatments.…”

Section: Discussionsupporting

confidence: 81%

Aluminium Involvement in Neurotoxicity

Fulgenzi

Vietti

Ferrero

2014

BioMed Research International

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The aetiology of neurodegenerative diseases (ND) seems to involve susceptibility genes and environmental factors. Toxic metals are considered major environmental pollutants. Following our study of a case of multiple sclerosis (MS) improvement due to removal of aluminium (Al) and other toxic metals, we have examined the possible relationship between Al intoxication and ND. We used the slow intravenous treatment with the chelating agent EDTA (calcium disodium ethylene diamine tetraacetic acid) (chelation test) to remove Al and detected it in the urine collected from the patients for 12 hours. Patients affected by MS represented 85.6% of total ND. Al was present in 44.8% of cases comprehensive of ND and healthy patients. Al levels were significantly higher in ND patients than in healthy subjects. We here show that treatment of patients affected by Al burden with ten EDTA chelation therapies (EDTA intravenous administration once a week) was able to significantly reduce Al intoxication.

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Section: Discussionsupporting

confidence: 81%

Aluminium Involvement in Neurotoxicity

Fulgenzi

Vietti

Ferrero

2014

BioMed Research International

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“…However, the binding of chelating agent EDTA to toxic metals enabled the patient to progressively eliminate elevated urinary concentrations of aluminium, lead and mercury. EDTA performs stable complexes with metals in function of mass, pH and affinity (Corsello et al 2009). The tissue of origin of toxic metals before removal by EDTA is possibly the CNS, but also other tissues are involved.…”

Section: Discussionmentioning

confidence: 99%

“…In the specific case here described, the patient's detoxification from heavy metals seems to create the environmental conditions useful to improve the clinical signs of MS. We previously used the chelation therapy to cure a patient who was treated many years ago with mercury-containing pharmaceuticals and developed neurologic symptoms (Corsello et al 2009). It has been recently demonstrated that EDTA chelation therapy, without added vitamin C, decreased oxidative DNA damage and lipid peroxidation (Roussel et al 2009).…”

Section: Discussionmentioning

confidence: 99%

A case of multiple sclerosis improvement following removal of heavy metal intoxication

et al. 2012

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Multiple sclerosis (MS) is a chronic progressive disease of the central nervous system (CNS) provoking disability and neurological symptoms. The exact causes of SM are unknown, even if it is characterized by focal inflammatory lesions in CNS accompanied by autoimmune reaction against myelin. Indeed, many drugs able to modulate the immune response of patients have been used to treat MS. More recently, toxic metals have been proposed as possible causes of neurodegenerative diseases. The objective of this study is to investigate in vivo the impact of heavy metal intoxication in MS progression. We studied the case of a patient affected by MS, who has been unsuccessfully treated for some years with current therapies. We examined his levels of toxic heavy metals in the urine, following intravenous "challenge" with the chelating agent calcium disodium ethylene diamine tetraacetic acid (EDTA).The patient displayed elevated levels of aluminium, lead and mercury in the urine. Indeed, he was subjected to treatment with EDTA twice a month. Under treatment, the patient revealed in time improved symptoms suggestive of MS remission. The clinical data correlated with the reduction of heavy metal levels in the urine to normal range values. Our case report suggests that levels of toxic metals can be tested in patients affected by neurodegenerative diseases as MS.

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“…In the past we had already reported how mercury contained in drugs can be removed by EDTA chelation treatment (Corsello et al 2009). This study shows how the very same treatment can help remove toxic metals from a RA patient and how important oxidative status profile is in helping diagnose the stages of an autoimmune disease, such as RA.…”

Section: Discussionmentioning

confidence: 99%

Metal chelation therapy in rheumathoid arthritis: a case report

et al. 2011

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Toxic metals are involved in the pathogenesis of some neurodegenerative and vascular diseases and are known to impair the immune system functions. We report here the case of a patient affected by heavy metal intoxication, who had developed an autoimmune disease. There was evidence of aluminium, cadmium and lead intoxication in a 63-year old Italian woman affected by rheumatoid arthritis (RA). We treated the patient with calcium disodium edetate (EDTA) once a week for a year in order to remove traces of heavy metal intoxication. Oxidative status profile was carried out at the beginning and after 6 months' EDTA chelation. At the end of the treatment, the patient did not show any signs of metal intoxication, RA symptoms and oxidative status improved.

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The usefulness of chelation therapy for the remission of symptoms caused by previous treatment with mercury-containing pharmaceuticals: a case report

Cited by 21 publications

References 11 publications

Aluminium Involvement in Neurotoxicity

Aluminium Involvement in Neurotoxicity

A case of multiple sclerosis improvement following removal of heavy metal intoxication

Metal chelation therapy in rheumathoid arthritis: a case report

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