The usefulness of factor XIII levels in Crohn's disease

Cougard, Pierre-Alain; Desjeux, Ariadne; Vitton, Véronique; Baumstarck, Karine; Lesavre, Nathalie; Grimaud, Jean–Charles

doi:10.1016/j.crohns.2011.11.016

Cited by 5 publications

(3 citation statements)

References 17 publications

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“…Factor XIII is the final enzyme in the coagulation cascade and is essential for hemostasis and fibrinolysis. During an inflammatory flare in CD, consumption of this factor increases in digestive mucosa, with a subsequent decrease in its serum levels [31].…”

Section: Discussionmentioning

confidence: 99%

Integrated serum proteins and fatty acids analysis for putative biomarker discovery in inflammatory bowel disease

Manfredi

Conte

Barberis

et al. 2019

Journal of Proteomics

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Inflammatory bowel disease (IBD) is a chronic inflammatory condition of unknown etiology that can develop in any portion of the digestive tract but which has a high incidence especially in the terminal ileum and/or in the colon. The diagnosis and management of IBD, including Crohn's disease (CD) and ulcerative colitis (UC), is still challenging, and the presence of intestinal inflammation is, to date, a primary criterion for its diagnosis and differentiation from other diseases. Moreover, there is no decisive gold standard diagnostic test based on patient history and physical examination, supplemented with objective laboratory, radiological, endoscopic and histological findings.This study analyzed plasma proteins and fatty acids using mass spectrometry-based techniques. Quantitation of low-abundance plasma proteins was performed by depleting 14 high-abundance proteins, followed by tryptic digestion and LC-MS analysis, while fatty acids were analyzed using GC-MS.We used bioinformatic tools to identify several new potential biomarkers for an early and non-invasive diagnosis of IBD, and to differentiate CD from UC. Moreover, the diagnostic power of the MS-identified biomarkers was also corroborated by Western Blot and ELISA assays. Hence, we identified the biological functions and pathways involved in the various subsets of IBD.Coagulation, fibrinolysis and acute phase response processes were found to be strongly involved in the condition. The involvement of several fatty acids, such as anti-inflammatory mediators, was also identified. Finally, proteomic and lipidomic data were integrated by using combinatorial and multivariate analyses to discover new combined biomarkers and to study the molecular pathways involved in IBD.

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Section: Discussionmentioning

confidence: 99%

Integrated serum proteins and fatty acids analysis for putative biomarker discovery in inflammatory bowel disease

Manfredi

Conte

Barberis

et al. 2019

Journal of Proteomics

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“…Inflammatory bowel diseases (IBD) have long been associated with decreased FXIII levels. A recent study in Crohn’s disease has shown, however, that FXIII levels cannot be recommended as a marker for disease activity [82]. The mechanisms leading to decreased FXIII levels in IBD are controversially discussed.…”

Section: Fxiii and Immune Defense And Inflammationmentioning

confidence: 99%

New developments in the area of factor XIII

Schroeder

Köhler

2013

Journal of Thrombosis and Haemostasis

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To cite this article: Schroeder V, Kohler HP. New developments in the area of factor XIII. J Thromb Haemost 2013; 11: 234-44.Summary. Coagulation factor (F)XIII is best known for its role in fibrin stabilization and cross-linking of antifibrinolytic proteins to the fibrin clot. From patients with congenital FXIII deficiency, it is known that FXIII also has important functions in wound healing and maintaining pregnancy. Over the last decade more and more research groups with different backgrounds have studied FXIII and have unveiled putative novel functions for FXIII. FXIII, with its unique role as a transglutaminase among the other serine protease coagulation factors, is now recognized as a multifunctional protein involved in regulatory mechanisms and construction and repair processes beyond hemostasis with possible implications in many areas of medicine. The aim of this review was to give an overview of exciting novel findings and to highlight the remarkable diversity of functions attributed to FXIII. Of course, more research into the underlying mechanisms and (patho-)physiological relevance of the many described functions of FXIII is needed. It will be exciting to observe future developments in this area and to see if and how these interesting findings may be translated into clinical practice in the future.

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“…Although genetic, infectious, and immunological factors may play roles in Crohn's disease (CD), the etiology of CD remains idiopathic. In the course of CD, it is challenging to differentiate between CD flare and inflammation-unrelated intestinal distress [ 1 ]. Moreover, CD frequently presented with extraintestinal manifestations, which should be interpreted both clinically and biologically.…”

Section: Introductionmentioning

confidence: 99%

Serum Omentin-1 as a Disease Activity Marker for Crohn’s Disease

et al. 2014

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Background and Aim. It remains challenging to determine the inflammatory activity in Crohn's disease (CD) for lack of specific laboratory markers. Recent studies suggest that serum omentin-1 is associated with inflammatory response. We aimed to assess the potential of serum omentin-1 as a marker of disease activity in CD patients. Methods. Serum omentin-1 concentrations were determined by enzyme-linked immunosorbent assay (ELISA) in patients with CD (n = 240), functional gastrointestinal disorders (FGDs, n = 120), and healthy controls (HC, n = 60) and evaluated for correlation with disease activity. Expression of omentin-1 in colonic tissues from patients with CD was also analyzed by real-time PCR and Western blotting. Serum omentin-1 levels as an activity index were evaluated using a receiver operating characteristic (ROC) curve. Results. Serum omentin-1 concentrations were significantly decreased in active CD patients compared with patients in remission, FGDs, and HC (all P < 0.001). Expression of omentin-1 was decreased at mRNA and protein levels in inflamed colonic tissues in active CD than that in noninflamed colonic tissues. Serum omentin-1 levels were negatively correlated with disease activity in CD, better than C-reactive protein (CRP). Conclusion. Our results indicate that serum and colonic omentin-1 expressions are decreased in active CD patients. The correlation of serum omentin-1 with disease activity in CD is superior to that of CRP. Serum omentin-1 is a potential marker for CD disease activity.

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The usefulness of factor XIII levels in Crohn's disease

Abstract: Our results confirm that factor XIII levels are decreased in CD patients but cannot be recommended as a marker for the disease activity.

Cited by 5 publications

References 17 publications

Integrated serum proteins and fatty acids analysis for putative biomarker discovery in inflammatory bowel disease

Integrated serum proteins and fatty acids analysis for putative biomarker discovery in inflammatory bowel disease

New developments in the area of factor XIII

Serum Omentin-1 as a Disease Activity Marker for Crohn’s Disease

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