The usefulness of fully three-dimensional OSEM algorithm on lymph node metastases from lung cancer with 18F-FDG PET/CT

Inoue, Kazuaki; Moriya, Etsuo; Suzuki, Takayuki; Ohnuki, Yoshiko; Sato, Takashi; Kitamura, Hiroyuki; Sasaki, Tatsuya; Fukushi, Masahiro; Moriyama, Noriyuki; Fujii, Hirofumi

doi:10.1007/s12149-010-0462-y

Cited by 7 publications

(4 citation statements)

References 23 publications

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“…In OSEM2D, 3D data is generally converted into 2D data using a rebinning step such as Fourier rebinning method to reduce the reconstruction time. In the clinical field, OSEM3D reportedly improves the image quality, compared with OSEM2D [ 10 ]. In addition, OSEM3D with point spread function correction, such as OSEM3D followed by maximum a posteriori (MAP), is used in the preclinical field and has been reported to exhibit a higher uniformity, higher recovery coefficient, and lower spill over ratio than either OSEM2D or FBP [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Oxygen-15 labeled CO2, O2, and CO PET in small animals: evaluation using a 3D-mode microPET scanner and impact of reconstruction algorithms

et al. 2017

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BackgroundPositron emission tomography (PET) studies using 15O-labeled CO2, O2, and CO have been used in humans to evaluate cerebral blood flow (CBF), the cerebral oxygen extraction fraction (OEF), and the cerebral metabolic rate of oxygen (CMRO2) and cerebral blood volume (CBV), respectively. In preclinical studies, however, PET studies using 15O-labeled gases are not widely performed because of the technical difficulties associated with handling labeled gases with a short half-life. The aims of the present study were to evaluate the scatter fraction using 3D-mode micro-PET for 15O-labeled gas studies and the influence of reconstruction algorithms on quantitative values.Nine male SD rats were studied using the steady state inhalation method for 15O-labeled gases with arterial blood sampling. The resulting PET images were reconstructed using filtered back projection (FBP), ordered-subset expectation maximization (OSEM) 2D, or OSEM 3D followed by maximum a posteriori (OSEM3D-MAP). The quantitative values for each brain region and each reconstruction method were calculated by applying different reconstruction methods.ResultsThe quantitative values for the whole brain as calculated using FBP were 46.6 ± 12.5 mL/100 mL/min (CBF), 63.7 ± 7.2% (OEF), 5.72 ± 0.34 mL/100 mL/min (CMRO2), and 5.66 ± 0.34 mL/100 mL (CBV), respectively. The CBF and CMRO2 values were significantly higher when the OSEM2D and OSEM3D-MAP reconstruction methods were used, compared with FBP, whereas the OEF values were significantly lower when reconstructed using OSEM3D-MAP.ConclusionsWe evaluated the difference in quantitative values among the reconstruction algorithms using 3D-mode micro-PET. The iterative reconstruction method resulted in significantly higher quantitative values for CBF and CMRO2, compared with the values calculated using the FBP reconstruction method.Electronic supplementary materialThe online version of this article (10.1186/s13550-017-0335-7) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Oxygen-15 labeled CO2, O2, and CO PET in small animals: evaluation using a 3D-mode microPET scanner and impact of reconstruction algorithms

et al. 2017

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“…Rajaram et al, in their 2D PET/CT study evaluating the impact of emission-transmission misregistration on myocardial blood flow quantification, artificially created 5-and 10-mm misregistrations along both the x-axis (left) and the z-axis (cranial) such that the lung parenchyma in CT overlapped the anterior and lateral LV walls in PET (6). PET/CT systems with 3D OSEM combined with TOF and PSF modeling have been shown to significantly improve PET image quality (9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(22)(23)(24)(25)(26). However, it is still unknown whether the influence of PET/CT misregistration on myocardial uptake is greater for 3D PET/CT than for 2D PET/CT.…”

Section: Discussionmentioning

confidence: 99%

“…3D PET has higher sensitivity than 2D PET, substantially improving the signal-to-noise ratio in PET images (9). Image reconstruction using 3D ordered-subset expectation maximization (OSEM) improves both spatial resolution and contrast-to-noise ratio in comparison with filtered backprojection reconstruction (10)(11)(12). In addition, recent 3D PET/CT scanners use time-of-flight (TOF) and point-spread-function (PSF) modeling, further improving spatial resolution, signal-to-noise ratio, and contrastto-noise ratio (12)(13)(14)(15)(16)(17)(18).…”

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confidence: 99%

The Effect of Misregistration Between CT-Attenuation and PET-Emission Images in ¹³N-Ammonia Myocardial PET/CT

Tomita

Ishida

Ichikawa

et al. 2016

J. Nucl. Med. Technol.

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In 2-dimensional cardiac PET/CT, misregistration between the PET and CT images due to respiratory and cardiac motion causes tracer uptake to appear substantially reduced. The resolution and quality of the images have been considerably improved by the use of 3-dimensional (3D) PET acquisitions. In the current study, we investigated the impact that misregistration between PET and CT images has on myocardial 13 N-ammonia uptake in images reconstructed with 3D ordered-subset expectation maximization combined with time-of-flight and point-spread-function modeling. Methods: Eight healthy volunteers (7 men and 1 woman; mean age ± SD, 53 ± 19 y) underwent 13 N-ammonia cardiac PET/CT at rest. First, any misregistration between the PET and CT images was manually corrected to generate reference images. Then, the images were intentionally misregistered by shifting the PET images from the reference images by a degree of 1, 2, 3, 4, 5, 10, and 15 mm along both the x-axis (left) and the z-axis (cranial). For each degree of misregistration, the PET images were reconstructed using the CT-attenuation images. The left ventricular short-axis PET/CT images were divided into 4 segments: anterior wall, inferior wall, lateral wall, and septum. The erroneous decrease in myocardial uptake in basal, mid, and apical slices was visually graded using a 4-point scale (0 5 none, 1 5 mild, 2 5 moderate, and 3 5 severe). Wall-to-septum uptake ratios were evaluated for the anterior, inferior, and lateral walls in the basal, mid, and apical slices. Results: A statistically significant reduction in myocardial 13 N-ammonia uptake in the anterior (P , 0.01) and lateral (P , 0.05) walls was observed when misregistration was 10 mm or more. The uptake ratios for the anterior, lateral, and inferior walls in the reference images were 1.00 ± 0.04, 0.96 ± 0.08, and 0.91 ± 0.03, respectively. The ratios for the anterior and lateral walls significantly decreased when misregistration exceeded 10 mm (anterior wall, 0.80 ± 0.06, P , 0.0001; lateral wall, 0.82 ± 0.07, P , 0.01), whereas the ratio for the inferior wall was relatively small at all 7 degrees of misregistration (0.86 ± 0.05 at 15-mm misregistration, P 5 0.06). Conclusion: In PET/CT images reconstructed with 3D ordered-subset expectation maximization combined with time-of-flight and point-spreadfunction modeling, we found a statistically significant artifactual reduction in tracer uptake in heart regions overlapping lung when misregistration between PET and CT exceeded 10 mm. Myocardi al perfusion PET/CT with pharmacologic stress detects coronary artery disease by identifying regional reductions in tracer uptake (1). Accurate and reliable assessment of these regional reductions is essential for early detection and therapy when coronary artery disease is suspected (1,2). The CT data acquired in myocardial perfusion PET/CT studies are commonly used for attenuation correction (3). However, misregistration between PET-emission and CT-transmission data may occur up to 40% of the time (4). Studies using 2-d...

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“…In 3D-OSEM algorithms, every type of correction of the 3D-acquired image data is performed within the calculation loop of successive approximations, resulting in good quality images. 5 Although previous studies have reported that 3D-OSEM algorithm can provide higher image quality than FORE þ OSEM algorithm, 6,7 they did not study image data obtained with a short acquisition time.…”

Section: Introductionmentioning

confidence: 99%

3D-OSEM versus FORE + OSEM: Optimal Reconstruction Algorithm for FDG PET with a Short Acquisition Time

Tsuda,

Suzuki,

Toya

et al. 2023

World J Nucl Med

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Objective In this study, we investigated the optimal reconstruction algorithm in fluorodeoxyglucose (FDG) positron emission tomography (PET) with a short acquisition time. Materials and Methods In the phantom study, six spheres filled with FDG solution (sphere size: 6.23–37 mm; radioactivity ratio of spheres to background = 8:1) and placed in a National Electrical Manufacturers Association phantom were evaluated. Image acquisition time was 15 to 180 seconds, and the obtained image data were reconstructed using each of the Fourier rebinning (FORE) + ordered subsets expectation-maximization (OSEM) and 3D-OSEM algorithms. In the clinical study, mid-abdominal images of 19 patients were evaluated using regions of interest placed on areas of low, intermediate, and high radioactivity. All obtained images were investigated visually, and quantitatively using maximum standardized uptake value (SUV) and coefficient of variation (CV). Results In the phantom study, FORE + OSEM images with a short acquisition time had large CVs (poor image quality) but comparatively constant maximum SUVs. 3D-OSEM images showed comparatively constant CVs (good image quality) but significantly low maximum SUVs. The results of visual evaluation were well correlated with those of quantitative evaluation. Small spheres were obscured on 3D-OSEM images with short acquisition time, but image quality was not greatly deteriorated. The clinical and phantom studies yielded similar results. Conclusion FDG PET images with a short acquisition time reconstructed by FORE + OSEM showed poorer image quality than by 3D-OSEM. However, images obtained with a short acquisition time and reconstructed with FORE + OSEM showed clearer FDG uptake and more useful than 3D-OSEM in the light of the detection of lesions.

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The usefulness of fully three-dimensional OSEM algorithm on lymph node metastases from lung cancer with 18F-FDG PET/CT

Abstract: 3D-OSEM algorithm successfully improved the diagnostic accuracy of LN metastases in 3D-PET tests.

Cited by 7 publications

References 23 publications

Oxygen-15 labeled CO2, O2, and CO PET in small animals: evaluation using a 3D-mode microPET scanner and impact of reconstruction algorithms

Oxygen-15 labeled CO2, O2, and CO PET in small animals: evaluation using a 3D-mode microPET scanner and impact of reconstruction algorithms

The Effect of Misregistration Between CT-Attenuation and PET-Emission Images in ¹³N-Ammonia Myocardial PET/CT

3D-OSEM versus FORE + OSEM: Optimal Reconstruction Algorithm for FDG PET with a Short Acquisition Time

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The usefulness of fully three-dimensional OSEM algorithm on lymph node metastases from lung cancer with 18F-FDG PET/CT

Abstract: 3D-OSEM algorithm successfully improved the diagnostic accuracy of LN metastases in 3D-PET tests.

Cited by 7 publications

References 23 publications

Oxygen-15 labeled CO2, O2, and CO PET in small animals: evaluation using a 3D-mode microPET scanner and impact of reconstruction algorithms

Oxygen-15 labeled CO2, O2, and CO PET in small animals: evaluation using a 3D-mode microPET scanner and impact of reconstruction algorithms

The Effect of Misregistration Between CT-Attenuation and PET-Emission Images in 13N-Ammonia Myocardial PET/CT

3D-OSEM versus FORE + OSEM: Optimal Reconstruction Algorithm for FDG PET with a Short Acquisition Time

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The Effect of Misregistration Between CT-Attenuation and PET-Emission Images in ¹³N-Ammonia Myocardial PET/CT