The usefulness of glycated hemoglobin A1c (HbA1c) for identifying dysglycemic states in individuals without previously diagnosed diabetes

Adamska, Edyta; Waszczeniuk, Magdalena; Gościk, Joanna; Golonko, Anna; Wilk, Juliusz; Pliszka, Justyna; Maliszewska, Katarzyna; Lipińska, Danuta; Milewski, Robert; Wasilewska, Anna; Citko, Anna; Nikołajuk, Agnieszka; Ostrowska, Lucyna; Krętowski, Adam; Górska, Maria

doi:10.2478/v10039-012-0030-x

Cited by 18 publications

(19 citation statements)

References 22 publications

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“…In the present study, the sensitivity of HbA1c as a screening test for DM was significantly higher than that found in earlier studies . One possible reason could be the lack of repeat testing to confirm the diagnosis of DM in many of the earlier studies (as recommended by ADA guidelines), resulting in an overdiagnosis of DM.…”

Section: Discussioncontrasting

confidence: 83%

“…Using an HbA1c cut‐off point of 6.5% (48 mmol/mol), the pooled sensitivity and specificity from 12 studies in Eastern countries were 58.7% and 98.4%, respectively, whereas the pooled sensitivity and specificity from 13 studies in Western countries were 65.5% and 98.1%, respectively . In most of these studies, the diagnosis of DM was made using either a single positive FPG (≥126 mg/dL [7.0 mmol/L]), a single positive 2‐h PG (≥200 mg/dL [11.1 mmol/L]), or any one of the two tests . However, in clinical practice, American Diabetes Association (ADA) guidelines actually require that the diagnosis of DM be confirmed by repeat testing unless there is unequivocal hyperglycemia (i.e.…”

Section: Introductionmentioning

confidence: 99%

“…7 In most of these studies, the diagnosis of DM was made using either a single positive FPG (≥126 mg/dL [7.0 mmol/L]), [8][9][10][11] a single positive 2-h PG (≥200 mg/dL [11.1 mmol/L]), [12][13][14][15][16] or any one of the two tests. 5,[17][18][19][20][21][22][23][24][25][26][27][28][29][30][31] However, in clinical practice, American Diabetes Association (ADA) guidelines actually require that the diagnosis of DM be confirmed by repeat testing unless there is unequivocal hyperglycemia (i.e. the person is in hyperglycemic crisis or has classical symptoms of DM).…”

Section: Introductionmentioning

confidence: 99%

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Re‐examining the sensitivity of HbA1c to screen for diabetes mellitus

Yap

Ang

Quek

et al. 2017

Journal of Diabetes

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Section: Discussioncontrasting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Re‐examining the sensitivity of HbA1c to screen for diabetes mellitus

Yap

Ang

Quek

et al. 2017

Journal of Diabetes

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“…As it can be seen in Table average level of glucose in T2DM individuals from all BMI groups are in the range indicating diabetes, but not extremely high. Also levels of HbA1c, which reflects the past (over a period of 2–3 months) average concentrations of glucose in blood , are not exceeded substantially. Based on the study of Nathan et al.…”

Section: Resultsmentioning

confidence: 99%

CE‐MS‐based serum fingerprinting to track evolution of type 2 diabetes mellitus

et al. 2015

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Development of type 2 diabetes mellitus (T2DM) is preceded by insulin resistance (IR), which may evolve to impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT). IFG and IGT are considered as prediabetic states (PD). Prediabetes indicates the high risk for the future development of diabetes, it is estimated that up to 70% of prediabetics eventually develop T2DM. The risk of T2DM development is increased in overweight (OW) and obese (OB) people; however normal weight (NW) individuals also suffer from T2DM. The present study was designed to evaluate whether changes in polar metabolites induced by T2DM evolution are different between NW, overweight and obese individuals. CE-MS serum fingerprinting was performed on 197 serum samples obtained from OW, OB, and NW humans whom were IR, prediabetics, diabetics or with normal glucose homeostasis. Metabolic changes evoked by the progression of T2DM differ between obese, overweight, and normal weight subjects. Based on obtained results several metabolites can be proposed as a promising target to track T2DM evolution; BCAA in OW and NW humans, lysine in OB, while acetylcarnitine and methionine independently on body mass index. Validation of obtained results on larger population is required.

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“…The cut-off value of HbA1c for diagnosis of diabetes has been a matter of controversy and debate worldwide. Gomyo et al, 9 Farhan et al, 10 Adamska et al, 11 Martin et al, 12 Bae et al, 13 Zemlin et al, 14 Tankova et al, 15 Ghazanfari et al, 16 Li et al, 17 Kim et al 18 had proposed values of 5. 23,24 (ABCD) gives an even higher level of 7.2% to rule in diabetes.…”

Section: Resultsmentioning

confidence: 99%

A study on assessment of HbA1c level as a diagnostic criterion of type 2 diabetes mellitus

et al. 2015

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Aims and Objectives:We compared performance of HbA1c in diagnosis of type 2 diabetes mellitus with that of fasting plasma glucose and tried to determine cut off point of HbA1c for optimum sensitivity and specifi city in a population of eastern India both from urban and rural background. Materials and Methods: The analysis was conducted in persons aged between 40 and 80 years, visiting our institution, who are newly diagnosed as diabetic and non-diabetic attending hospital for some other reason, who underwent FPG and HbA1c testing, in the time period January 2013 to August 2014. Results: From 100 individuals (mean age 54.6 years) HbA1c ≥ 6.5% produced sensitivity of 90% and specifi city of 72%, positive predictive value 76.27% and negative predictive value 87.80% when compared to FPG ≥ 126 mg% as standard. By ROC curve, optimum cut off point for HbA1c was found to be 7.05% for diagnosis of diabetes. Conclusion: Using a cut off value of HbA1c of 7% may optimise detection of diabetes mellitus and ensure proper patient care.

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The usefulness of glycated hemoglobin A1c (HbA1c) for identifying dysglycemic states in individuals without previously diagnosed diabetes

Cited by 18 publications

References 22 publications

Re‐examining the sensitivity of HbA1c to screen for diabetes mellitus

Re‐examining the sensitivity of HbA1c to screen for diabetes mellitus

CE‐MS‐based serum fingerprinting to track evolution of type 2 diabetes mellitus

A study on assessment of HbA1c level as a diagnostic criterion of type 2 diabetes mellitus

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