The usefulness of ovarian volume, antral follicle count and age as predictors of menopausal status

Giacobbe, Marcelo; Pinto‐Neto, Aarão Mendes; Martinez, Edson Zangiacomi

doi:10.1080/13697130410001713715

Cited by 25 publications

(10 citation statements)

References 12 publications

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“…Breed differences between antral follicle counts of Brahman, Senepol, and Angus cows have been detected (Alvarez et al, 2000), but reports providing estimates of heritability of antral follicle count in cattle were not found in the literature. Strong relationships between follicle counts and age at menopause in women (Broekmans et al, 2004;Giacobbe et al, 2004) coupled with heritability estimates of age at menopause near 0.50 (van Asselt et al, 2004;Murabito et al, 2005) indicate that much of the variation in antral follicle count may be inherited.…”

Section: Genetic and Genomic Heritabilitiesmentioning

confidence: 99%

PHYSIOLOGY AND ENDOCRINOLOGY SYMPOSIUM: How single nucleotide polymorphism chips will advance our knowledge of factors controlling puberty and aid in selecting replacement beef females1,2,3,4

Snelling

Cushman

Fortes

et al. 2012

Journal of Animal Science

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ABSTRACT:The promise of genomic selection is accurate prediction of the genetic potential of animals from their genotypes. Simple DNA tests might replace low-accuracy predictions for expensive or lowly heritable measures of puberty and fertility based on performance and pedigree. Knowing with some certainty which DNA variants (e.g., SNP) affect puberty and fertility is the best way to fulfill the promise. Several SNP from the BovineSNP50 assay have tentatively been associated with reproductive traits including age at puberty, antral follicle count, and pregnancy observed on different sets of heifers. However, sample sizes are too small and SNP density is too sparse to definitively determine genomic regions harboring causal variants affecting reproductive success. Additionally, associations between individual SNP and similar phenotypes are inconsistent across data sets, and genomic predictions do not appear to be globally applicable to cattle of different breeds. Discrepancies may be a result of different QTL segregating in the sampled populations, differences in linkage disequilibrium (LD) patterns such that the same SNP are not correlated with the same QTL, and spurious correlations with phenotype. Several approaches can be used independently or in combination to improve detection of genomic factors affecting heifer puberty and fertility. Larger samples and denser SNP will increase power to detect real associations with SNP having more consistent LD with underlying QTL. Meta-analysis combining results from different studies can also be used to effectively increase sample size. Highdensity genotyping with heifers pooled by pregnancy status or early and late puberty can be a cost-effective means to sample large numbers. Networks of genes, implicated by associations with multiple traits correlated with puberty and fertility, could provide insight into the complex nature of these traits, especially if corroborated by functional annotation, established gene interaction pathways, and transcript expression. Example analyses are provided to demonstrate how integrating information about gene function and regulation with statistical associations from whole-genome SNP genotyping assays might enhance knowledge of genomic mechanisms affecting puberty and fertility, enabling reliable DNA tests to guide heifer selection decisions.

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Section: Genetic and Genomic Heritabilitiesmentioning

confidence: 99%

PHYSIOLOGY AND ENDOCRINOLOGY SYMPOSIUM: How single nucleotide polymorphism chips will advance our knowledge of factors controlling puberty and aid in selecting replacement beef females1,2,3,4

Snelling

Cushman

Fortes

et al. 2012

Journal of Animal Science

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“…26–28 Validity for the use of AFC as a marker of ovarian reserve is supported by studies showing AFC to covary with chronological age, correlate with ovarian response in treatments using Assisted Reproductive Technologies (ARTs), and, in statistical models, predict menopause onset. 2729–37 In contrast to hormonal indicators, AFC is stable across consecutive menstrual cycles and across follicular and luteal phases of the menstrual cycle. 3338–39 Taken together, evidence supports the value of utilizing AFC as a tool in studying ovarian follicle loss and the factors that may influence this process.…”

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confidence: 99%

Depressive symptomatology, psychological stress, and ovarian reserve

Bleil

Adler²,

Pasch³

et al. 2012

Menopause

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Objective To examine psychological factors in relation to antral follicle count (AFC), a marker of ovarian reserve, in a multiethnic sample of 683 pre-menopausal women in the Ovarian Aging (OVA) Study. Methods In cross-sectional analyses, linear regression was performed to determine whether AFC decline across women varied over levels of depression as well as depression in combination with psychological stress. The total and subscale scores of the Center for Epidemiological Studies Depression Scale (CESD) were used to measure depression and the Perceived Stress Scale was used to measure psychological stress. Results Following covariate-adjustment, the 2-way interaction of age-x-positive affect and the 3-way interaction of age-x-positive affect-x-stress were related to AFC (b = 0.047, p = .036; b = 0.012, p = .099, respectively). In stratified analyses, stress was related to AFC in women with low positive affect (b = −.070, p = .021) but not in women with high positive affect (b = .018, p = .54). AFC decline across women was progressively higher in women with low positive affect who reported low (−0.747 follicles/year), mid (−0.920 follicles/year), and high (−1.112 follicles/year) levels of stress. Results examining the CESD total and remaining subscale scores were all non-significant (p’s > .05). Conclusions Cross-sectional evidence suggests that 1) women with low positive affect may experience accelerated AFC decline and 2) low positive affect may be a vulnerability factor, or, alternatively, high positive affect may be a protective factor, in moderating the negative effects of psychological stress on AFC decline.

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“…Until the very late stages of reproductive aging, most sonographic cycle characteristics in populations with proven fertility remain “normal” (te Velde and Pearson, 2002). Only at a mean age of approximately 46 to 48 years do normal menstrual cycle characteristics tend to disappear (te Velde and Pearson, 2002; Giacobbe et al 2004). …”

Section: Ovarian Reserve and Physical Testingmentioning

confidence: 99%

Biomarkers of Ovarian Reserve

2008

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Abstract:The primary function of the female ovary is the production of a mature and viable oocyte capable of fertilization and subsequent embryo development and implantation. At birth, the ovary contains a fi nite number of oocytes available for folliculogenesis. This fi nite number of available oocytes is termed "the ovarian reserve". The determination of ovarian reserve is important in the assessment and treatment of infertility. As the ovary ages, the ovarian reserve will decline. Infertility affects approximately 15%-20% of reproductive aged couples. The most commonly used biomarker assay to assess ovarian reserve is the measurement of follicle stimulating hormone (FSH) on day 3 of the menstrual cycle. However, antimüllerian hormone and inhibin-B are other biomarkers of ovarian reserve that are gaining in popularity since they provide direct determination of ovarian status, whereas day 3 FSH is an indirect measurement. This review examines the physical tools and the hormone biomarkers used to evaluate ovarian reserve.

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The usefulness of ovarian volume, antral follicle count and age as predictors of menopausal status

Abstract: Ovarian volume, antral follicle count and chronological age are all individually predictive of menopausal status, with similar accuracies.

Cited by 25 publications

References 12 publications

PHYSIOLOGY AND ENDOCRINOLOGY SYMPOSIUM: How single nucleotide polymorphism chips will advance our knowledge of factors controlling puberty and aid in selecting replacement beef females1,2,3,4

PHYSIOLOGY AND ENDOCRINOLOGY SYMPOSIUM: How single nucleotide polymorphism chips will advance our knowledge of factors controlling puberty and aid in selecting replacement beef females1,2,3,4

Depressive symptomatology, psychological stress, and ovarian reserve

Biomarkers of Ovarian Reserve

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