The usefulness of the retina for identifying people with type 2 diabetes with prodromal stages of dementia

Ciudin, Andreea; Hernández, Cristina; Simó-Servat, Olga; Simó, Rafael

doi:10.1016/j.neubiorev.2024.105592

Cited by 2 publications

(1 citation statement)

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“…Recent studies confirm that dementia and cognitive impairments are significant complications associated with Type 2 diabetes (T2D) [ 39 ]. With the increasing prevalence of T2D and challenges in self-management among patients, the incidence of dementia is expected to rise [ 40 ]. Although the effect of diabetes duration on dementia onset requires further study.…”

Section: Discussionmentioning

confidence: 99%

The relationship between diabetes and the dementia risk: a meta-analysis

Cao,

Yang,

et al. 2024

Diabetol Metab Syndr

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Background The link between diabetes and dementia risk is not well understood. This study evaluates the factors linking diabetes to dementia onset, providing guidance for preventing dementia in diabetic patients. Methods This analysis utilized databases such as PubMed, Embase, Web of Science, and the Cochrane Library to review literature from January 31, 2012, to March 5, 2023. Articles were rigorously assessed using specific inclusion and exclusion criteria. The Newcastle-Ottawa Scale (NOS) was used to evaluate the quality of the studies. Data analysis was performed with STATA 15.0. Results The study analyzed 15 articles, covering 10,103,868 patients, with 8,821,516 diagnosed with diabetes. The meta-analysis reveals a substantial association between diabetes and an increased risk of dementia [RR: 1.59, 95%CI (1.40–1.80), P < 0.01, I²=96.4%]. A diabetes duration of less than five years is linked to a higher dementia risk [RR: 1.29, 95%CI (1.20–1.39), P < 0.01, I²=92.6%]. Additionally, hypoglycemia significantly raises dementia risk [RR: 1.56, 95%CI (1.13–2.16), P < 0.01, I²=51.5%]. Analyses of blood sugar control, glycated hemoglobin, and fasting blood sugar indicated no significant effects on the onset of dementia. Conclusion Diabetes notably increases dementia risk, particularly where diabetes duration is under five years or hypoglycemia is present. Registration The research protocol was registered with PROSPERO and assigned the registration number CRD42023394942.

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Section: Discussionmentioning

confidence: 99%

The relationship between diabetes and the dementia risk: a meta-analysis

Cao,

Yang,

et al. 2024

Diabetol Metab Syndr

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Abnormal eye movements: relationship with clinical symptoms and predictive value for Alzheimer’s disease

Qi,

Lian,

Guo

et al. 2024

Front. Aging Neurosci.

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BackgroundAbnormal eye movements occur at the early stages of Alzheimer’s disease (AD). However, the characteristics of abnormal eye movements of patients with AD and their relationship with clinical symptoms remain inconsistent, and their predictive value for diagnosing and monitoring the progression of AD remains unclear.MethodsA total of 42 normal controls, 63 patients with mild cognitive impairment due to AD (AD-MCI), and 49 patients with dementia due to AD (AD-D) were recruited. Eye movements were assessed using the EyeKnow eye-tracking and analysis system. Cognitive function, neuropsychiatric symptoms, and activities of daily living were evaluated using various rating scales, and correlation analyses and receiver operating characteristic curves were performed.ResultsPatients with AD exhibited increased number of offsets and offset degrees, prolonged offset duration, and decreased accuracy in lateral fixation; reduced accuracy, prolonged saccadic duration, and decreased velocity in prosaccade; decreased accuracy and corrected rate, prolonged corrected antisaccadic duration, and reduced velocity in antisaccade; and reduced accuracy and increased inhibition failures in memory saccade. Eye movement parameters were correlated with global cognition and the cognitive domains of memory, language, attention, visuospatial ability, execution function, and activities of daily living. Subgroup analysis indicated that the associations between eye movements and clinical symptoms in patients with AD were influenced by disease severity and history of diabetes. In the AD-D and AD with diabetes groups, these associations diminished. Nevertheless, the associations persisted in the AD-MCI and AD without diabetes groups. The areas under the curves for predicting AD, AD-MCI, and AD-D were 0.835, 0.737, and 0.899, respectively (all p < 0.05).ConclusionPatients with AD exhibit distinct patterns of abnormal eye movements. Abnormal eye movements are significantly correlated with global cognition, multiple cognitive domains, and activities of daily living. Abnormal eye movements have a considerable predictive value for the diagnosis and progression of AD.

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The usefulness of the retina for identifying people with type 2 diabetes with prodromal stages of dementia

Cited by 2 publications

References 56 publications

The relationship between diabetes and the dementia risk: a meta-analysis

The relationship between diabetes and the dementia risk: a meta-analysis

Abnormal eye movements: relationship with clinical symptoms and predictive value for Alzheimer’s disease

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