This chapter aims to provide comprehensive guidelines for the successful integration of technology and the adoption of innovative teaching methodologies to enhance students' skills acquisition and effectiveness. Drawing upon experiences and implementations in the Mena region, specifically the GCC region, this chapter addresses key questions surrounding the selection and implementation of innovative teaching methods. The structure of the chapter encompasses an introduction to innovative teaching methodologies, identification of skills and appropriate methodologies, monitoring of implementation, the impact of technology, and a concluding summary of findings and future research directions.