The Utility of 99m Tc Depreotide Compared With F-18 Fluorodeoxyglucose Positron Emission Tomography and Surgical Staging in Patients With Suspected Non-small Cell Lung Cancer

Kahn, Daniel; Menda, Yusuf; Kernstine, Kemp H.; Bushnell, David; McLaughlin, Kelley; Miller, Sara J.; Berbaum, Kevin S.

doi:10.1378/chest.125.2.494

Cited by 41 publications

(42 citation statements)

References 26 publications

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“…Our results demonstrated that 99m Tc-octreotide scintigraphy is a sensitive test for the detection of primary lung cancer, as reported previously (32,33). The sensitivity of tomographic 99m Tc-octreotide scintigraphy for the detection of primary lung cancer is similar to that of 18 F-FDG coincidence imaging.…”

Section: Discussionsupporting

confidence: 88%

Role of 99mTc-Octreotide Acetate Scintigraphy in Suspected Lung Cancer Compared with 18F-FDG Dual-Head Coincidence Imaging

Wang¹,

Wang²,

Yao³

et al. 2007

Journal of Nuclear Medicine

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The aim of this study was to evaluate the clinical value of tomographic 99m Tc-octreotide acetate (hereafter, 99m Tc-octreotide) scintigraphy in the detection of patients with suspected lung cancer in comparison with that of 18 F-FDG dual-head coincidence imaging (DHC). Methods: Forty-four consecutive patients with suspected pulmonary neoplasms underwent tomographic 99m Tc-octreotide scintigraphy and 18 F-FDG coincidence imaging using the same gantry. The region of interest was drawn on the entire primary lesion. The tumor-to-normal tissue tracer values for both 99m Tc-octreotide and 18 F-FDG were determined using region of interests and expressed as T/N r and T/N m , respectively. Final diagnosis was confirmed by histopathologic analysis or clinical follow-up. Results: Thirty-one of the 44 patients had lung cancer-6 with small cell lung cancer (SCLC) and 25 with non-small cell lung cancer (NSCLC). Thirteen of the 44 patients had benign lung lesions. The sensitivity, specificity, positive predictive value, and negative predictive value of 99m Tc-octreotide were 100%, 75.7%, 90.1%, and 100%, respectively, and of 18 F-FDG DHC were 100%, 46.1%, 83.8%, and 100%, respectively. In the 31 patients with malignant tumors, all 38 abnormal lymph nodes in 20 patients showed abnormal high focal uptake of 18 F-FDG; only 7 patients with 10 regional lymph adenopathies showed moderate uptake of 99m Tc-octreotide. Thirteen patients with 39 distant sites of abnormal uptake visualized (imaging stage IV) with 99m Tc-octreotide included 2 patients with brain metastases, 6 patients with pleural invasion and multiple bone metastasis, 2 patients with contralateral internal lung metastasis and pleural invasion, and 3 patients with only multiple bone metastasis. The final diagnosis was confirmed by histopathology or clinical follow-up. Conclusion: The sensitivity of 99m Tc-octreotide for the detection of lung cancer at the primary lesion was comparable with that of 18 F-FDG coincidence imaging. Tomographic 99m Tc-octreotide scintigraphy had lower sensitivity for the detection of hilar and mediastinal lymph node metastasis compared with that of 18 F-FDG coincidence PET, but it had high sensitivity for the detection of remote metastatic lesions. However, because of the small population, further investigation is necessary.

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Section: Discussionsupporting

confidence: 88%

Role of 99mTc-Octreotide Acetate Scintigraphy in Suspected Lung Cancer Compared with 18F-FDG Dual-Head Coincidence Imaging

Wang¹,

Wang²,

Yao³

et al. 2007

Journal of Nuclear Medicine

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“…The exception was a 10-mm small bronchioloalveolar carcinoma where the expected resolution of a gamma camera could fail. False-negative results have been reported previously where lesion size and location could be confounding factors (5,6,(11)(12)(13)14). As in all nuclear medicine imaging, the sensitivity is higher in larger tumors, and false negatives are more often observed in smaller tumors.…”

Section: Discussionmentioning

confidence: 86%

Role of scintigraphy with technetium-99m depreotide in the diagnosis and management of patients with suspected lung cancer

et al. 2008

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“…The sensitivity and specificity of 99m Tc-depreotide for the diagnosis of malignancy in this pilot study were 93% and 88%, respectively. A larger trial was done at the University of Iowa with 166 subjects who had suspected lung cancer (14). The performance of 99m Tc-depreotide for the diagnosis of malignancy in pulmonary nodules or masses and the detection of mediastinal nodal metastasis was compared with that of 18 F-FDG.…”

Section: M Tc-labeled Somatostatin Receptor Imagingmentioning

confidence: 99%

“…The sensitivity and specificity of 99m Tc-depreotide for the diagnosis of malignancy in pulmonary lesions were 94% and 51%, respectively; those of 18 F-FDG PET were 96% and 71%, respectively. For the detection of mediastinal nodal metastasis, the respective sensitivity and specificity were 68% and 70% for 99m Tc-depreotide and 81% and 77% for 18 F-FDG PET (14).…”

Section: M Tc-labeled Somatostatin Receptor Imagingmentioning

confidence: 99%

“…This agent is an analog of 99m Tc-depreotide (13,14). In a phase I trial, patients with metastatic or recurrent lung tumors that could not be treated surgically and that were demonstrated to have somatostatin receptors by positive 99m Tc-P2045 imaging results were treated with escalating doses of 188 Re-P2045 (56).…”

Section: Radiolabeled Peptide Therapy In United Statesmentioning

confidence: 99%

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Radiopeptide Imaging and Therapy in the United States

Graham¹,

Menda²

2011

J Nucl Med

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The Utility of 99m Tc Depreotide Compared With F-18 Fluorodeoxyglucose Positron Emission Tomography and Surgical Staging in Patients With Suspected Non-small Cell Lung Cancer

Cited by 41 publications

References 26 publications

Role of 99mTc-Octreotide Acetate Scintigraphy in Suspected Lung Cancer Compared with 18F-FDG Dual-Head Coincidence Imaging

Role of 99mTc-Octreotide Acetate Scintigraphy in Suspected Lung Cancer Compared with 18F-FDG Dual-Head Coincidence Imaging

Role of scintigraphy with technetium-99m depreotide in the diagnosis and management of patients with suspected lung cancer

Radiopeptide Imaging and Therapy in the United States

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