The utility of alternative models in particulate matter air pollution toxicology

Smoot, J; Padilla, Stephanie; Farraj, Aimen K.

doi:10.1016/j.crtox.2022.100077

Cited by 7 publications

(5 citation statements)

References 108 publications

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“…However, Manjunatha et al used diesel standard reference material, which varies from biomass or LPG combustion, as evidenced by varied PAH concentrations compared to ours. A literature review by Smoot et al highlighted additional studies that reported morphological effects, similar to those found by Manjunatha et al and our present study. , …”

Section: Resultssupporting

confidence: 92%

“…A literature review by Smoot et al highlighted additional studies that reported morphological effects, similar to those found by Manjunatha et al and our present study. 22,61 Embryonic Photomotor Response (EPR). The embryonic photomotor response (EPR) is a behavioral response to changing light conditions frequently used as an indicator of biological toxicity, specifically, of later adverse effects on development.…”

Section: ■ Methodsmentioning

confidence: 99%

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Indoor and Personal PM_2.5 Samples Differ in Chemical Composition and Alter Zebrafish Behavior Based on Primary Fuel Source

Victoria,

Trine,

Hystad

et al. 2023

Environ. Sci. Technol.

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Section: Resultssupporting

confidence: 92%

Section: ■ Methodsmentioning

confidence: 99%

Indoor and Personal PM_2.5 Samples Differ in Chemical Composition and Alter Zebrafish Behavior Based on Primary Fuel Source

Victoria,

Trine,

Hystad

et al. 2023

Environ. Sci. Technol.

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“…A recent study reported that PM is toxic to not only humans but also zebrafish (Hyun et al, 2022;Ritz et al, 2019;Smoot et al, 2022). So, first we have confirmed whether the PM shown toxicity to the embryos.…”

Section: Octopus Minor Extract (Ome) Attenuate Particulate Matter (Pm...supporting

confidence: 64%

Long arm octopus (Octopus minor) extract prevents eye injury caused by particulate matter exposure in zebrafish (Danio rerio) embryos

Ranasinghe,

Cha

2024

Fish Aquat Sci

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Particulate matter (PM) is a mixture of microscopic solid inhalable particles including airborne liquid droplets, and it is implicated with several diseases. The eye does not have a protective barrier among the human organs, consequently it get directly exposed to environmental substances such as PM. The scarcity of treatments for damage to the eyesight and the vision and eye structure being closely related to the structure and function of the central nervous system highlights the cruciality of novel therapeutics. In this study was conducted using in vivo zebrafish vertebrate model which is a useful model due to the conserved genes between human. We found that protective effect of Octopus minor extract against particulate matter-induced adverse effects on eye development in zebrafish (Danio rerio) embryos by regulating antioxidant and anti-inflammatory mRNA expression.

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“…The increasing perception of the risk to human health resulting from exposure to PM, coupled with the dispersion and movement in the atmosphere of air masses carrying PM, implies that the effects on humans and animals, in many areas, including marine organisms, are often unknown. Therefore, Smoot et al [38] suggested that, in addition to traditional in vivo models using mammals, other models (e.g., Danio rerio, Caenorhabditis elegans and Drosophila melanogaster) should be used to obtain information on PM toxicity. In the present study, we selected the mussel as a biological model to study the effects of PM on marine biota.…”

Section: Discussionmentioning

confidence: 99%

Effects of Exposure to Urban Atmospheric Particulate Matter Suspended in Seawater on the Mussel Mytilus galloprovincialis

Rodrigues,

Ferreira,

Duarte

et al. 2024

Environments

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Atmospheric particulate matter (PM) contains numerous constituents, including organic molecules, inorganic ions, and metals, with some of them possessing hazardous properties. Although mainly associated with air pollution, PM can rapidly be transferred from air and land to aquatic ecosystems, and consequently poses a risk to marine biota. The aim of this work was to evaluate how urban atmospheric PM (a standard reference mixture of urban PM, known to contain various organic and inorganic contaminants), suspended in seawater, may cause toxicity in marine organisms. To this purpose, mussels (Mytilus galloprovincialis) were exposed to two concentrations of suspended PM: 5.7 and 11.4 mg/L. After 7, 14, and 21 days, the animals were collected and the gills and digestive gland were analysed for stress biomarkers (CAT, SOD, GPX, GST, MDA, and Ubi). In general, the results show that exposure to different concentrations of PM caused an increase in GST, UBI, and GPx activities compared to their respective controls. The average activities of GST (87.65 ± 30.23 nmol/min/mg of total protein) in the gills of the animals exposed to 11.4 mg/L of PM increased after 21 days of exposure, and the activity of GPx (8.04 ± 3.09 nmol/min/mg of total protein) in the gills increased after 14 days in the animals exposed to 5.7 mg/L of PM. MDA results also provided information on cellular damage, with the most pronounced effects being found in the gills of exposed mussels. This study confirms that mussels are useful as “early warning” indicators of environmental contamination and provides important information on the effects of PM on marine biota.

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The utility of alternative models in particulate matter air pollution toxicology

Cited by 7 publications

References 108 publications

Indoor and Personal PM_2.5 Samples Differ in Chemical Composition and Alter Zebrafish Behavior Based on Primary Fuel Source

Indoor and Personal PM_2.5 Samples Differ in Chemical Composition and Alter Zebrafish Behavior Based on Primary Fuel Source

Long arm octopus (Octopus minor) extract prevents eye injury caused by particulate matter exposure in zebrafish (Danio rerio) embryos

Effects of Exposure to Urban Atmospheric Particulate Matter Suspended in Seawater on the Mussel Mytilus galloprovincialis

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The utility of alternative models in particulate matter air pollution toxicology

Cited by 7 publications

References 108 publications

Indoor and Personal PM2.5 Samples Differ in Chemical Composition and Alter Zebrafish Behavior Based on Primary Fuel Source

Indoor and Personal PM2.5 Samples Differ in Chemical Composition and Alter Zebrafish Behavior Based on Primary Fuel Source

Long arm octopus (Octopus minor) extract prevents eye injury caused by particulate matter exposure in zebrafish (Danio rerio) embryos

Effects of Exposure to Urban Atmospheric Particulate Matter Suspended in Seawater on the Mussel Mytilus galloprovincialis

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Product

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Indoor and Personal PM_2.5 Samples Differ in Chemical Composition and Alter Zebrafish Behavior Based on Primary Fuel Source

Indoor and Personal PM_2.5 Samples Differ in Chemical Composition and Alter Zebrafish Behavior Based on Primary Fuel Source