The Utility of Camptothecin as a Synergist of &lt;I&gt;Bacillus thuringiensis&lt;/I&gt; var. &lt;I&gt;kurstaki&lt;/I&gt; and Nucleopolyhedroviruses Against &lt;I&gt;Trichoplusia ni&lt;/I&gt; and &lt;I&gt;Spodoptera exigua&lt;/I&gt;

Sun, Shifeng; Cheng, Zhongshan; Fan, Jing; Cheng, Xinghu; Pang, Yi

doi:10.1603/ec12014

Cited by 18 publications

(16 citation statements)

References 52 publications

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“…31,32 Although the mechanism of action of CPT is not fully understood, a previous study showed that CPT could cause visible changes in the midguts from the lepidopteran pests Trichoplusia ni and Spodoptera exigua, such as losing the single layer of epithelial cells and disrupting the peritrophic membrane. 33 The present data provide evidence for CPT-induced apoptosis in SL-1 cells and midgut cells of S. litura. Consistent with these data, Zhang et al have reported that CPT caused Sf21 and IOZCAS-Spex-II cell apoptosis via a mitochondrial-dependent apoptosis signal transduction pathway.…”

Section: Discussionsupporting

confidence: 58%

“…Azadirachtin could be categorised as an antimitotic insecticide that targets cell division during the G2/M phase and causes proliferation inhibition and apoptosis in SL‐1 cells . Although the mechanism of action of CPT is not fully understood, a previous study showed that CPT could cause visible changes in the midguts from the lepidopteran pests Trichoplusia ni and Spodoptera exigua , such as losing the single layer of epithelial cells and disrupting the peritrophic membrane . The present data provide evidence for CPT‐induced apoptosis in SL‐1 cells and midgut cells of S. litura .…”

Section: Discussionsupporting

confidence: 52%

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Camptothecin‐induced expression of programmed cell death gene 11 in Spodoptera litura

Gong¹,

Wang²,

Huang³

et al. 2013

Pest Management Science

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Section: Discussionsupporting

confidence: 58%

Section: Discussionsupporting

confidence: 52%

Camptothecin‐induced expression of programmed cell death gene 11 in Spodoptera litura

Gong¹,

Wang²,

Huang³

et al. 2013

Pest Management Science

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“…Additionally, a recent study showed that CPT could cause visible changes in the midguts from the lepidopteran pests Trichoplusia ni and Spodoptera exigua , such as losing the single layer of epithelial cells and disrupting the peritrophicmembrane . Investigations by Zhong et al also demonstrated that CPT‐induced apoptosis in SL‐1 cells and midgut cells of S. litura . Consistent with these results, Zhang et al recently revealed that CPT caused Sf21 and IOZCAS‐Spex‐II cell apoptosis via a mitochondrial‐dependent apoptosis signal transduction pathway, suggesting that its mode of action may be related to apoptosis.…”

Section: Biological Activity Of Cpt and Related Derivativesmentioning

confidence: 98%

Perspectives on Biologically Active Camptothecin Derivatives

et al. 2015

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Camptothecins (CPTs) are cytotoxic natural alkaloids that specifically target DNA topoisomerase I. Research on CPTs has undergone a significant evolution from the initial discovery of CPT in the late 1960s through the study of synthetic small molecule derivatives to investigation of macromolecular constructs and formulations. Over the past years, intensive medicinal chemistry efforts have generated numerous CPT derivatives. Three derivatives, topotecan, irinotecan, and belotecan, are currently prescribed as anticancer drugs, and several related compounds are now in clinical trials. Interest in other biological effects, besides anticancer activity, of CPTs is also growing exponentially, as indicated by the large number of publications on the subject during the last decades. Therefore, the main focus of the present review is to provide an ample but condensed overview on various biological activities of CPT derivatives, in addition to continued up-to-date coverage of anticancer effects.

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“…2). 290 Lee et al Nomuraea rileyi는 30종이 넘는 나비목 유충에 대한 병원성을 보이며 밤나방과(Noctuidae)에 속하는 유충들에 감염을 잘 일으 켜 난방제 나비목 해충 방제를 위해서 많은 연구가 이루어 지고 있다 (Ignoffo, 1981;Ignoffo and Boucias, 1992;Sanchez-Peña, 2000;Martins et al, 2005). (Jaramillo et al, 2005;Santos et al, 2007;Brito et al, 2008;Paula et al, 2011;Sun et al, 2012). 또한 다른 친환경 방제제인 여러 가지 친환경 추출물 또는 천적 곤충과 곰팡이 살충제를 함 께 처리함으로써 곰팡이 살충제의 낮은 살충력을 보완 하면서 동시에 두 가지 모두 살충효과를 높일 수 있는 것에 대해 많은 연 구가 활발히 이루어지고 있다 (Wekesa et al, 2007;Rashki et al, 2009;Park and Kim, 2012).…”

Section: 고 찰unclassified

Characteristics and Virulence Assay of Entomopathogenic Fungus Nomuraea rileyi for the Microbial Control of Spodoptera exigua (Lepidoptera: Noctuidae)

Lee¹,

Shin²,

Ko³

et al. 2012

The Korean Journal of Microbiology

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To date, chemical control remains the most common way to reduce beet armyworm (Spodoptera exigua) populations. However, this insect has become more tolerant or resistant to many chemical insecticides and the insect larvae usually hide inside hollow, tube-like leaves of host plant so they were difficult to kill by spraying insecticides. The use of viral and bacterial insecticide to solve these problems has not been successful because of their novel feeding habit. To overcome these problems, in this study, the biological characteristics and virulence of an entomopathogenic fungus isolated from the cadaver of larvae beet armyworm were investigated. Isolated entomopathogenic fungus was identified as Nomeraea rileyi (Farlow) Samson by morphological examinations and genetic identification using sequences of the ITS, β-tubulin gene and EF1-α regions. This fungus was named as N. rileyi SDSe. Virulence tests against 3rd larvae of beet armyworm were conducted with various conidial suspensions from 1×10 4 to 10 8 conidia/ml of N. rileyi SDSe in laboratory conditions. Mortality rate of beet armyworm showed from 20 to 54% and the virulence increased with increasing conidial concentrations. Although N. rileyi SDSe showed low mortality rate against beet armyworm, it is expected that N. rileyi SDSe will be used effectively in the integrated pest management programs against the beet armyworm.

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The Utility of Camptothecin as a Synergist of <I>Bacillus thuringiensis</I> var. <I>kurstaki</I> and Nucleopolyhedroviruses Against <I>Trichoplusia ni</I> and <I>Spodoptera exigua</I>

Cited by 18 publications

References 52 publications

Camptothecin‐induced expression of programmed cell death gene 11 in Spodoptera litura

Camptothecin‐induced expression of programmed cell death gene 11 in Spodoptera litura

Perspectives on Biologically Active Camptothecin Derivatives

Characteristics and Virulence Assay of Entomopathogenic Fungus Nomuraea rileyi for the Microbial Control of Spodoptera exigua (Lepidoptera: Noctuidae)

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