The Utility of CONUT Score in Diffuse Large B Cell Lymphoma Patients

Abstract

Background: Assessment of nutritional status is gaining more importance in cancer patients because nutritional status is associated with response to chemotherapy, side effects of cancer treatment and disease progression. Several studies that were performed on patients with solid malignancies have shown the clinical significance of CONUT score (Controlling nutritional status). Aims: Therefore we tried to show the utility of CONUT score in newly diagnosed Diffuse Large B Cell Lymphoma (DLBCL) patients which is the most frequently seen B Cell Lymphoma type. Methods: Data of the 81 patients diagnosed with DLBCL were retrospectively evaluated. The primary endpoint of our study was to evaluate and classify newly diagnosed DLBCL patients according to the CONUT score and secondary endpoint was to show any relationship with CONUT score and overall survival. Patients' demographics, treatment details, stages, extranodal involvements, the presence of bulky disease, response to treatment options and overall survivals were evaluated from medical recordings. Results: Univariate cox regression analysis CONUT score was associated with overall survival (HR: 2.34–95% CI: 1.55–3.24 P = 0.040). On multivariate Cox regression analysis model CONUT score ≥5 was found to be an independent prognostic factor for overall survival (HR: 4.96–95% CI: 1.77–13.97- P = 0.002). Conclusion: The value of obtaining nutritional status in cancer patients is underestimated and CONUT score is simple, easily applicable and in our opinion is going to fill the gap especially in DLBCL patients.

Assessment of nutritional status and clinical outcomes: A comprehensive retrospective analysis of critically ill patients

“…Plenty of studies are researching gastrointestinal, [ 13 , 14 , 24 ] cardiovascular, [ 10 , 18 ] urogenital, [ 19 ] cerebrovascular, [ 12 ] hematopoietic [ 11 , 25 ] system disorders, oncological malignancies, [ 9 , 26 – 28 ] and nutritional status. To the best of our knowledge, our study is the first to systematically evaluate the indications for intensive care unit hospitalization and compare them with the nutritional score.…”

Prognostic and clinicopathological significance of the Controlling Nutritional Status (CONUT) score in patients with lymphoma: a meta-analysis

“…Later, five studies that did not focus on CONUT (n=3), were meeting abstracts (n=1) and did not study lymphoma (n=1) were eliminated. Ultimately, seven studies were enrolled in the present meta-analysis, involving 2060 patients with Open access lymphoma [22][23][24][25][26][27][28] (figure 1, online supplemental table S3).…”

“…Three studies were carried out in Japan, 22 23 27 two in China 26 28 and two in Turkey. 24 25 The enrolled articles all used the English language and were of retrospective design, [22][23][24][25][26][27][28] with sample sizes between 81 and 615 patients (median: 266). Five were single-centre studies 23-26 28 and two were multicentre trials.…”

“…Five were single-centre studies 23-26 28 and two were multicentre trials. 22 27 Four studies enrolled patients with diffuse large B cell lymphoma (DLBCL), [22][23][24][25] whereas the remaining three included extranodal NK/T cell lymphoma, 28 peripheral T cell lymphoma 27 and lymphoma cases. 26 Three studies adopted a CONUT cutoff value of ≥5, 22 25 27 two used a cut-off of ≥2 24 28 and the two remaining each chose a cut-off of ≥4 23 and ≥7.…”

“…21 The legitimacy of using CONUT scores while predicting the prognosis of lymphoma cases has been widely investigated but no consistent results can be obtained. [22][23][24][25][26][27][28] For instance, higher CONUT scores (usually ≥5) were reported to significantly predict the prognosis of lymphoma cases in some studies, whereas other scholars did not show a significant relationship between lymphoma prognosis and use of CONUT scores. 23 Therefore, through a comprehensive literature review, the present meta-analysis focused on identifying the precise role of CONUT scores when estimating lymphoma prognoses.…”