The Utility of Exposure and Effect-Based Analysis in the Ecotoxicological Assessment of Transformation Products

Müller, Yvonne; Hollert, Henner; Küppers, Stefan; Schiwy, Sabrina; Zhu, Linyan; Crawford, Sarah E.

doi:10.1021/bk-2016-1242.ch005

Cited by 2 publications

(2 citation statements)

References 84 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…4 The interaction between TPs and the parent can exert additive, antagonistic, or potentially synergistic effects. 5 Therefore, assessing the environmental and health risks caused by emerging pollutants and their TPs is never straightforward.…”

Section: Introductionmentioning

confidence: 99%

“…The resulting mixture of the parent compound and TPs may show differential toxicity to their original forms. , Some TPs may pose higher risks than the parent, as exemplified by the formation of toxic enedials and oxoenals causing cellular damage when phenolic compounds are treated by UV/H 2 O 2 or ultraviolet (UV) . The interaction between TPs and the parent can exert additive, antagonistic, or potentially synergistic effects . Therefore, assessing the environmental and health risks caused by emerging pollutants and their TPs is never straightforward.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Identification of Transformation Products of Organic UV Filters by Photooxidation and Their Differential Estrogenicity Assessment

Lu,

Chow,

Sun

et al. 2023

Environ. Sci. Technol.

View full text Add to dashboard Cite

Organic ultraviolet filters (OUVFs) are extensively released into aquatic environments, where they undergo complex phototransformation. However, there is little knowledge regarding their transformation products (TPs) and associated endocrine disruption potentials. In the present study, we characterized the chemical and toxicological profiles of TPs for two common OUVFs, oxybenzone (BP3) and ethylhexyl methoxycinnamate (EHMC), by photooxidation under environmentally relevant conditions. It is hypothesized that TPs of the tested OUVFs will show varied estrogenicity at different reaction times. High-resolution liquid chromatography quadrupole time-of-flight mass spectrometry (LC-QTOF-MS) identified 17 TPs of 7 m/z for BP-3 and 13 TPs of 8 m/z for EHMC at confidence levels ≤2. Five novel TPs of 2 m/z were reported for the first time with structure-diagnostic MS/MS spectra. Estrogenicity assessment using the MCF-7-luc cell line showed discrepant estrogenic activities exhibited by OUVF-TPs over time. Specifically, BP3-TPs exhibited significantly greater estrogenicity than the parent at several reaction times, whereas EHMC-TPs displayed fluctuating estrogenicity with a declining trend. Correlation analysis coupled with molecular docking simulations further suggested several TPs of BP3 as potential endocrine disruptive compounds. These findings underscore the necessity of considering mixtures during chemical testing and risk assessment and highlight the potentially greater risks associated with post-transformation cocktails.

show abstract

Section: Introductionmentioning

confidence: 99%