The utility of fasting glucose for detection of prediabetes

Cheng, Cynthia; Kushner, Harvey; Falkner, Bonita

doi:10.1016/j.metabol.2005.10.003

Cited by 47 publications

(29 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As an example, a revealing study involving young African-American subjects compared FPG to OGTT to diagnose glucose intolerance. FPG (110 mg/dl) detected only 27.4% of cases, OGTT 87,1%; when the 2003 ADA criteria were applied, the FPG threshold of 100 mg/dl did not perform any better, identifying only 28.9% of glucose intolerance cases (Cheng et al, 2006). Furthermore, beside the evidence that FPG cannot be equated to 2hPG (Carnevale Schianca et al, 2003;Rizza, 2010), it has been demonstrated that 2hPG more efficiently predicts the risk of heart disease than FPG (DECODE Study Group, 1998).…”

Section: The History Of the Ogttmentioning

confidence: 89%

“…The attempt to screen glucose tolerance using FPG alone has been disavowed by several epidemiological observations. At variance with one single study involving three ethnic groups in the United Kingdom (Unwin et al, 1998), reporting a better prediction for diabetes from FPG with respect to 2hPG, FPG alone was shown to underestimate the diabetes prevalence when compared to 2hPG (Cheng et al, 2006;Harris et al, 1997). To ameliorate the diagnostic power of FPG, in 2003 the ADA lowered from 110 to 100 mg/dl its cut-off to define prediabetes (Genut et al, 2003).…”

Section: The History Of the Ogttmentioning

confidence: 99%

“…Despite various attempts to lower the cut-off of FPG to avoid the necessity of executing OGTT, there are extensive data showing that OGTT is more sensitive than FPG alone for diagnosing diabetes or prediabetes (Cheng et al, 2006;Harris et al, 1997;Meigs et al, 2003).…”

Section: The Ogtt In "Action"mentioning

confidence: 99%

See 2 more Smart Citations

The Oral Glucose Tolerance Test: An Old but Irreplaceable Test to Evaluate Glucose Metabolism and Cardiovascular Risk

Fra¹,

Bartoli²,

Schianca³

2011

Medical Complications of Type 2 Diabetes

View full text Add to dashboard Cite

Section: The History Of the Ogttmentioning

confidence: 89%

Section: The History Of the Ogttmentioning

confidence: 99%

See 1 more Smart Citation

The Oral Glucose Tolerance Test: An Old but Irreplaceable Test to Evaluate Glucose Metabolism and Cardiovascular Risk

Fra¹,

Bartoli²,

Schianca³

2011

Medical Complications of Type 2 Diabetes

View full text Add to dashboard Cite

“…Some studies have compared different methods of diabetes screening [19], most proposing the use of FPG in patients with risk factors for DM and OGTT in patients with FPG between 5.5 and 6.9 mmol/l. One recent study determined the utility of FPG alone for detecting prediabetes concluding that FPG testing (threshold value of 5.5 mmol/l) alone may be inadequate for diagnosing prediabetes and that OGTT is a more sensitive method for detecting the prediabetic condition in their high-risk population [20]. …”

Section: Introductionmentioning

confidence: 99%

Role of Fasting Plasma Glucose, Glycated Haemoglobin and Homeostatic Model Assessment in the Detection of Glucose Intolerance in Adult Hypopituitary Patients during Growth Hormone Replacement Therapy

et al. 2007

View full text Add to dashboard Cite

Aims: This study was designed to determine the sensitivity and specificity of conventional criteria for diagnosis of impaired glucose tolerance (IGT) in a high-risk population of GH-treated GH deficient (GHD) adults. Methods: 33 hypopituitary GHD patients with HbA_1c >5.1% and 13 gender- and age-matched control GHD patients were selected. Oral glucose tolerance test (OGTT), fasting plasma glucose (FPG), HbA_1c, and homeostatic model assessment (HOMA) parameters were determined in all patients. Receiver operator characteristic curves were used to determined sensitivity and specificity for the detection of glucose intolerance as defined by plasma glucose >7.8 mmol/l at 120 min during OGTT. Results: Sensitivity and specificity for this purpose for HbA_1c (>5.1%) were 89 and 17%; for FPG (>5.5 mmol/l): 78 and 67%; for FPG (>6.1 mmol/l): 56 and 89%; for HOMA-derived β-cell function (βCF) (<40%): 78 and 58%; for HOMA-derived insulin sensitivity (IS) (<70%): 11 and 89%, and for βCF-IS hyperbolic product (βCF-IS) (<54%): 89 and 75%, respectively. Conclusions: This study shows that FPG (>5.5 mmol/l) and βCF-IS have high sensitivity and relatively high specificity for the detection of IGT and confirms that measurement of FPG or calculation of βCF-IS provides appropriate safety surveillance in hypopituitary patients on GH replacement.

show abstract

“…4 For an FPG test, a venous blood sample is drawn in the physician's office following a 12-hour overnight fast. This specimen is analyzed in a core laboratory.…”

mentioning

confidence: 99%

The Importance of Testing for Pre-diabetes—Using the Right Tool

Chajewski¹,

Nichols²

2009

US Endocrinology

View full text Add to dashboard Cite

Type 2 diabetes, formerly referred to as non-insulin-dependent or adult-onset diabetes, is a chronic medical condition caused by insulin resistance, inadequate insulin secretion, or a combination of both.1 It differs from type 1 diabetes in that it can be acquired due to a multitude of lifestyle and medical factors rather than being caused by the autoimmune destruction of insulin-secreting beta cells in the pancreas. AbstractDiabetes is one of the most prevalent chronic diseases affecting the US healthcare system today, and increasing emphasis is being placed on disease prevention and screening. Early detection of pre-diabetes can be of great benefit to patients as studies have shown that signs of early diabetic complications often exist at the time of diagnosis. Early intervention has been shown to delay, and in some cases prevent, the progression from pre-diabetes to diabetes. Venous blood sampling and core laboratory analysis remain the gold standard for diagnosis. While

show abstract

The utility of fasting glucose for detection of prediabetes

Cited by 47 publications

References 22 publications

The Oral Glucose Tolerance Test: An Old but Irreplaceable Test to Evaluate Glucose Metabolism and Cardiovascular Risk

The Oral Glucose Tolerance Test: An Old but Irreplaceable Test to Evaluate Glucose Metabolism and Cardiovascular Risk

Role of Fasting Plasma Glucose, Glycated Haemoglobin and Homeostatic Model Assessment in the Detection of Glucose Intolerance in Adult Hypopituitary Patients during Growth Hormone Replacement Therapy

The Importance of Testing for Pre-diabetes—Using the Right Tool

Contact Info

Product

Resources

About