The Utility of Fecal Calprotectin in an Acute Flare of Inflammatory Bowel Disease

Wilen, Jonathan; Kumar, Shria; Lichtiger, Simon

doi:10.14309/00000434-201810001-00722

American Journal of Gastroenterology

2018

DOI: 10.14309/00000434-201810001-00722

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The Utility of Fecal Calprotectin in an Acute Flare of Inflammatory Bowel Disease

Jonathan Wilen

Shria Kumar

Simon Lichtiger

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2025

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Early subclinical stages of the inflammatory bowel diseases: insights from human and animal studies

Kelly,

Sartor,

Rawls

2025

American Journal of Physiology-Gastrointestinal and Liver Physi

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The inflammatory bowel diseases (IBD) occur in genetically susceptible individuals that mount inappropriate immune responses to their microbiota leading to chronic intestinal inflammation. The natural history of IBD progression begins with early subclinical stages of disease that occur before clinical diagnosis. Improved understanding of those early subclinical stages could lead to new or improved strategies for IBD diagnosis, prognostication or prevention. Here we review our current understanding of the early subclinical stages of IBD in humans including studies from first-degree relatives of IBD patients and members of the general population who go on to develop IBD. We also discuss representative mouse models of IBD that can be used to investigate disease dynamics and host-microbiota relationships during these early stages. In particular, we underscore how mouse models of IBD that develop disease later in life with variable penetrance may present valuable opportunities to discern early subclinical mechanisms of disease before histological inflammation and other severe symptoms become apparent.

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Early subclinical stages of the inflammatory bowel diseases: insights from human and animal studies

Kelly,

Sartor,

Rawls

2025

American Journal of Physiology-Gastrointestinal and Liver Physi

View full text Add to dashboard Cite

show abstract

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The Utility of Fecal Calprotectin in an Acute Flare of Inflammatory Bowel Disease

Cited by 1 publication

References 0 publications

Early subclinical stages of the inflammatory bowel diseases: insights from human and animal studies

Early subclinical stages of the inflammatory bowel diseases: insights from human and animal studies

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