The utility of fluorescence imaging in detecting primary and metastatic small bowel carcinoid tumors

Sarioglu, Ali Gunduz; Akgun, Ege; Uysal, Melis; Osman, Mohammed; Berber, Eren

doi:10.1016/j.amjsurg.2023.10.038

Cited by 3 publications

(1 citation statement)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, superficial liver metastases also exhibited brighter autofluorescence compared to normal liver parenchyma, suggesting overall a utility in detecting occult primary carcinoid tumors and their superficial liver metastases. 22…”

Section: Utility Of Autofluorescence For Small Bowel Carcinoidsmentioning

confidence: 99%

An update on the use of near‐infrared autofluorescence imaging in endocrine surgical procedures

Dabaghi,

Berber

2023

Journal of Surgical Oncology

Self Cite

View full text Add to dashboard Cite

Over the past decade, near‐infrared autofluorescence (NIRAF) imaging has been a major breakthrough in endocrine surgery. Although initial focus was directed at the parathyroid glands, subsequent work has also shown that non‐parathyroid neuroendocrine tumors also possess autofluorescence properties. The aim of this review is to present an update and synopsis about NIRAF applications in various endocrine surgical procedures. Methodology includes a review of the literature supplemented with expert opinion. Overall, our review reveals that the use of NIRAF may provide the surgeon with adjunctive critical information that has the potential to change the conduct of many various endocrine surgical procedures.

show abstract

Section: Utility Of Autofluorescence For Small Bowel Carcinoidsmentioning

confidence: 99%

An update on the use of near‐infrared autofluorescence imaging in endocrine surgical procedures

Dabaghi,

Berber

2023

Journal of Surgical Oncology

Self Cite

View full text Add to dashboard Cite

show abstract

Correlation Between Near‐Infrared Autofluorescence Properties and Sestamibi Uptakes of Parathyroid Glands in Primary Hyperparathyroidism

Akgun,

Ibrahimli,

Rahman

et al. 2024

Otolaryngol.--head neck surg.

View full text Add to dashboard Cite

ObjectiveNear‐infrared autofluorescence (NIRAF) characteristics of parathyroid glands in primary hyperparathyroidism (pHPT) vary, with unclarity regarding the underlying mechanism. Similarly, 99mTc‐sestamibi uptake in diseased parathyroid glands is variable. There is a suggestion that oxyphilic cell content may influence both imaging modalities. This study aims to analyze the relationship between NIRAF imaging characteristics, 99mTc‐sestamibi uptake, and cellular composition in pHPT.Study DesignRetrospective analysis of an Institutional Review Board‐monitored prospective database.SettingSingle tertiary referral center.MethodsNIRAF characteristics of parathyroid glands of patients with pHPT between 2019 and 2024 were compared with 99mTc‐sestamibi scan findings from a prospective database. Using third‐party software, brightness intensity and heterogeneity index (HI) of the glands were calculated. A subgroup of parathyroid glands obtained from consecutive patients with pHPT in 2020 to 2021 underwent histological analysis.ResultsA total of 428 patients with 638 diseased parathyroid glands were analyzed. Forty‐seven percent of the glands showed an uptake on 99mTc‐sestamibi scans. The brightness intensity of the NIRAF signals from parathyroid glands that were seen versus not seen on sestamibi was 2.1 versus 2.3 (P = .002) and HI 0.18 versus 0.17 (P = .35), respectively. On multivariate analysis, low autofluorescence intensity, high gland volume, and single adenoma were associated with detectability on 99mTc‐sestamibi scan (P < .0001). Intraglandular adipose tissue content was lower in diseased glands that were detected on 99mTc‐sestamibi scans (0% vs 5%, P < .0001).ConclusionOur findings indicate an inverse relationship between autofluorescence intensity and detectability on 99mTc‐sestamibi scans and a lack of correlation between different cell types and autofluorescence properties.

show abstract

From the Editor – In – Chief: Featured papers in the June 2024 issue

Chen

2024

The American Journal of Surgery

View full text Add to dashboard Cite

The utility of fluorescence imaging in detecting primary and metastatic small bowel carcinoid tumors

Cited by 3 publications

References 29 publications

An update on the use of near‐infrared autofluorescence imaging in endocrine surgical procedures

An update on the use of near‐infrared autofluorescence imaging in endocrine surgical procedures

Correlation Between Near‐Infrared Autofluorescence Properties and Sestamibi Uptakes of Parathyroid Glands in Primary Hyperparathyroidism

From the Editor – In – Chief: Featured papers in the June 2024 issue

Contact Info

Product

Resources

About