The utility of maternal mean platelet volume levels for early onset neonatal sepsis prediction of term infants

Çekmez, Yasemin; Güleçoğlu, Merve Dizdar; Özcan, Cemile; Karadeniz, Leyla; Grover, Kiran

doi:10.5603/gp.a2017.0058

Cited by 9 publications

(6 citation statements)

References 10 publications

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“…A microorganism infection causes an inflammatory reaction, which results in increased total leukocyte and neutrophil numbers (29,30). In addition, those with sepsis experienced a considerable enhancement in immature neutrophil count and I/T ratio than controls, which reveals the crucial role of CBC with a differential in the identification of EOS (P = 0.0001); this was also proven by Cekmez et al (31). Our results were not in line with those of Can et al (26), that reported no statistically significant differences in the I/T ratio between the EOS group and the control group.…”

Section: Discussionsupporting

confidence: 52%

Validity of Platelet to Lymphocyte Ratio and Neutrophil to Lymphocyte Ratio in Diagnosing Early-onset Neonatal Sepsis in Full-term Newborns

et al. 2022

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Background: This study aimed to evaluate the neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) as diagnostic adjunct tests for early-onset neonatal sepsis (EOS). Methods: This prospective cross-sectional study included 80 full-term neonates with confirmed EOS and 80 healthy newborns. All examinations were done 24 hours after birth. Neonatal sepsis (NS) was characterized as a positive blood culture with symptoms of infection. Positive diagnostic indicators, including I/T ratio > 0.2, total leukocytes [WBCs] of either 5109/L or > 15109/L, thrombocytopenia [150,000/mm3], CRP > 1 mg/dL, and procalcitonin >0.5 ng/mL were considered as NS. Results: As the predictors of EOS, the sensitivity of NLR and PLR was 67% and 70%, and their specificity was 99% and 73%, respectively. Also, positive predictive value (PPV) of NLR and PLR was 98% and 72%, respectively. We found a weak correlation between platelets and sepsis, Strong correlation between WBCs and PLR with sepsis, and a moderate correlation among the ratio of immature to total neutrophil counts (I/T ratio), all of which were significant. Besides, concerning NLR with sepsis, we found an inverse correlation between lymphocytes and sepsis. Conclusions: PLR and NLR are important predictive markers for EOS (PPV of NLR and PLR was 98% and 72%, respectively). Moreover, leukocytosis, thrombocytopenia, high c-reactive protein (CRP), high procalcitonin, and positive blood culture were correlated with the risk of NS. NLR and PLR showed more specificity than CRP and procalcitonin.

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Section: Discussionsupporting

confidence: 52%

Validity of Platelet to Lymphocyte Ratio and Neutrophil to Lymphocyte Ratio in Diagnosing Early-onset Neonatal Sepsis in Full-term Newborns

et al. 2022

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“…A fetal weight prediction model is created without the need for complex calculations and is also able to show the exact weight of the fetus. [17] In this study, the sensitivity and specificity of two-dimensional color Doppler ultrasound in the diagnosis of fetal developmental abnormalities were 78.38% and 82.60%, respectively, while the sensitivity and specificity of 4D color Doppler ultrasound in the diagnosis of fetal developmental abnormalities were 81.5% and 83.43%, respectively. The results showed that the application of 4D ultrasound scanning with GE-E10 equipment could effectively improve the accuracy of fetal weight estimation.…”

Section: Discussionmentioning

confidence: 57%

Predictive value and accuracy of prenatal four-dimensional color ultrasound for fetal abnormal development

Zhang

Jin

2023

Medicine

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To investigate the value and accuracy of prenatal GE-E10 ultrasound Equipment in predicting fetal abnormal development. 160 pregnant women and women who received prenatal ultrasound examination were selected. Before delivery, all pregnant women were examined by conventional two-dimensional and four-dimensional (4D) ultrasound. 18 fetuses with abnormal development were detected by gold standard in 160 pregnant women. Sensitivity and specificity of two-dimensional color ultrasound in diagnosing fetal abnormal development were 78.38% and 82.60%. The sensitivity and specificity of 4D color ultrasound in diagnosing fetal abnormal development were 81.15% and 83.43%. ROC showed that the AUC (0.873) of 4D color ultrasound was higher than that of two-dimensional color ultrasound (0.827). The diagnostic efficiency of 4D ultrasound is greater. The accuracy, specificity and sensitivity of 4D color ultrasound in the diagnosis of fetal abnormal development is high, and it is valuable for prenatal screening of macrosomia and low birth weight.

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“…The role of maternal mean platelet volume levels for the prediction early onset neonatal sepsis in term infants were also studied by Yasemin Cekmez, Merve Dizdar et al, [10] and found that MPV levels were statistically higher in the study group of mothers with infection than the control group. It is easy to predict the probability of sepsis in infants born to mothers who has clinical findings of chorioamnionitis, and other systemic infections.…”

Section: Discussionmentioning

confidence: 98%

Mean Platelet Volume in Neonatal Sepsis- A Case Control Study

Mohankumar¹,

Paulose²

2019

jemds

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BACKGROUND The size of platelets in circulation is indicated by Mean Platelet Volume (MPV). It is automatically measured while doing complete blood count in auto analyser. Newborn babies of mothers having risk factors for sepsis are screened for early detection of sepsis. Early signs and symptoms of septicaemia are nonspecific. Hence MPV as an additional parameter of neonatal sepsis will be very much valuable. This study aims to determine the role of Mean Platelet Volume as an additional marker in the diagnosis of neonatal sepsis (NS). METHODS This case-control study was conducted over a period of two years at Neonatal Intensive care Unit (NICU), Institute of Maternal and Child Health, Government Medical College, Calicut, Kerala. A total of 445 newborns were divided into 3 groups: Group A-Culture proven NS (n = 39), Group B-Clinical NS (n =183), and Group C-Apparently healthy control (n = 223). All patients in Group A & B were subjected to adequate assessment of history, full clinical examination, complete blood count including MPV, C-reactive protein (CRP) and blood culture. In group C, complete blood count including MPV was done and other investigations relevant to the case. RESULTS Septic neonates showed statistically higher values of MPV than control group. The diagnostic cutoff values of MPV for neonatal sepsis was taken as 10 fL. The mean MPV in culture proven NS (group A) was 10.9467. In clinical NS (group B) it was 10.4021 and in control (group C) it was 9.3509. CONCLUSIONS This study shows that MPV has a role as an additional marker in the diagnosis of neonatal sepsis.

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The utility of maternal mean platelet volume levels for early onset neonatal sepsis prediction of term infants

Cited by 9 publications

References 10 publications

Validity of Platelet to Lymphocyte Ratio and Neutrophil to Lymphocyte Ratio in Diagnosing Early-onset Neonatal Sepsis in Full-term Newborns

Validity of Platelet to Lymphocyte Ratio and Neutrophil to Lymphocyte Ratio in Diagnosing Early-onset Neonatal Sepsis in Full-term Newborns

Predictive value and accuracy of prenatal four-dimensional color ultrasound for fetal abnormal development

Mean Platelet Volume in Neonatal Sepsis- A Case Control Study

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