The utility of pretreatment systemic inflammatory response biomarkers on overall survival of cervical cancer patients stratified by clinical staging

Thuler, Luiz Cláudio Santos; Wariss, Bárbara Reis; Nogueira-Rodrigues, Angélica; Melo, Andréia Cristina de; Bergmann, Anke

doi:10.1016/j.ejogrb.2021.07.034

Cited by 6 publications

(6 citation statements)

References 25 publications

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“…A previous study also suggested that PSF 6 months after a stroke was linked to elevated plasma hs-CRP levels upon admission, and this outcome is in line with the findings of the present study [19]. Another inflammatory marker, PLR, has been recently gaining attention as an indicator that reflects the inflammatory state of the body, and is also used as a prognostic predictor in cancer patients [20][21][22], cardiovascular disease patients [23,24], stroke patients [25], and coronavirus disease-19 (COVID-19) patients. It is also attracting attention as a predictor of cytokine storm in patients infected with COVID-19 in the context of a pandemic [26,27].…”

Section: Discussionsupporting

confidence: 91%

Analysis of Factors Affecting Post-Stroke Fatigue: An Observational, Cross-Sectional, Retrospective Chart Review Study

et al. 2021

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Post-stroke fatigue (PSF) is one of the most common emotional and mood disorders in stroke survivors. Several studies have suggested associations between PSF and various factors. However, they describe conflicting results. Therefore, this study aimed to evaluate the factors affecting PSF. We retrospectively reviewed the medical records of 178 hospitalized stroke patients. The collected data were compared between the PSF and control groups. To evaluate the association between factors and PSF, regression analysis was conducted. A total of 96 patients (53.9%) were assigned to the PSF group, and 82 patients were assigned to the control group. Age, neurological deficits, cognitive dysfunction, degree of depression, hs-CRP, and ESR differed significantly between the two groups. For both types of stroke, multiple linear regression analyses showed that degree of depression and degree of inflammation were significantly associated with PSF. Through subgroup analysis, multiple linear regression analyses showed that the degree of depression in ischemic and hemorrhagic stroke and the platelet-to-lymphocyte ratio in hemorrhagic stroke had a significant association with PSF. In conclusion, post-stroke depression and degree of inflammation could be clinically significant predictors of PSF in all types of stroke patients. However, larger, prospective studies are required to obtain more concrete results.

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Section: Discussionsupporting

confidence: 91%

Analysis of Factors Affecting Post-Stroke Fatigue: An Observational, Cross-Sectional, Retrospective Chart Review Study

et al. 2021

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“…21 In some studies PLR correlated with survival outcomes 19,22 while some found NLR to have correlation with survival outcomes, 15,20,23 whereas some found both NLR and PLR to correlate with poorer survival outcomes. 16,24,25 In this study, ROC curve analysis of local recurrence yielded the NLR cutoff value as 2.45 (AUC ¼ 0.839) with a sensitivity of 82.6% and specificity of 77.7% and the PLR cutoff value 140.6 (AUC ¼ 0.892) with a sensitivity of 85.5% and specificity of 80.6%. This matched with another study, the sensitivity value for NLR was 82% and specificity 71% with a cutoff of 3.38 using ROC analyses and 72 and 70% with cutoff of 172.05 for PLR, respectively, for predicting stage with NLR and PLR.…”

Section: Discussionmentioning

confidence: 66%

“…21 In some studies PLR correlated with survival outcomes 19 22 while some found NLR to have correlation with survival outcomes, 15 20 23 whereas some found both NLR and PLR to correlate with poorer survival outcomes. 16 24 25…”

Section: Discussionmentioning

confidence: 99%

Pretreatment Systemic Inflammatory Markers, Neutrophil Lymphocyte Ratio, and Platelet Lymphocyte Ratio as a Prognostic Factor in Cervical Cancer: A Retrospective Study

Sarkar,

Mirza,

Das

et al. 2023

South Asian J Cancer

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Inflammation has been recognized as a promoter of the neoplastic process initiation and progression. Neutrophilia, lymphocytopenia, and thrombocytosis are hallmarks of inflammatory reaction. The aim of this study is to find the correlation and prognostic value of pretreatment neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR), with the recurrence in carcinoma cervix.Data of 208 biopsy-proven cases of squamous cell carcinoma cervix treated with definitive chemoradiotherapy were retrospectively analyzed. Neutrophil, lymphocyte, and platelet count at diagnosis were recorded and NLR and PLR were calculated. The cutoff value of NLR and PLR were calculated using receiver operator characteristics curve analysis. Correlation between locoregional recurrence (LRR) and NLR and PLR is evaluated. Median age of diagnosis is at 50 years. International Federation of Gynecology Obstetrics stage IIB was the most prevalent stage in this study. The NLR and PLR were statistically significantly affecting the LRR. The cutoff value of NLR was 2.45 with a sensitivity of 82.6% and specificity of 77.7%. The cutoff value for PLR was 140.6 with a sensitivity of 85.5% and specificity of 80.6%. On univariate regression analysis stage (p = 0.045), tumor grade (p = 0.001), addiction (p = 0.024), NLR (p < 0.001), and PLR (p < 0.001) were associated with LRR. Multivariate regression analysis showed that NLR (p = 0.005) risk group and PLR (p < 0.001) risk group are independent risk factors associated with LRR. Conclusion High value of NLR and PLR correlate with poor prognosis in squamous cell carcinoma cervix. Hence, these biomarkers may be used as surrogates for tumor prognosis.

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“…For example, in a recent study, Marchetti et al (7) observed that the neutrophil-lymphocyte ratio (NLR) was an independent prognostic marker for progression-free survival (PFS) in patients with high-grade advanced serous ovarian cancer. Another study (8), which recruited 1,266 patients with CC, showed that the platelet-lymphocyte ratio (PLR), NLR, derived NLR, and the PLR + NLR in combination showed equivalent efficacy as prognostic factors for overall survival (OS) in patients with locally advanced CC and are therefore considered promising prognostic biomarkers. The aforementioned studies (7,8) highlight the role of systemic inflammatory biomarkers in the prognosis of GC.…”

Section: Introductionmentioning

confidence: 99%

“…Another study (8), which recruited 1,266 patients with CC, showed that the platelet-lymphocyte ratio (PLR), NLR, derived NLR, and the PLR + NLR in combination showed equivalent efficacy as prognostic factors for overall survival (OS) in patients with locally advanced CC and are therefore considered promising prognostic biomarkers. The aforementioned studies (7,8) highlight the role of systemic inflammatory biomarkers in the prognosis of GC. The C-reactive protein (CRP)/albumin ratio (CRP/Alb) is an index based on measurement of serum CRP and Alb levels (9) and is calculated as the serum CRP level divided by the serum Alb level.…”

Section: Introductionmentioning

confidence: 99%

Prognostic Role of the C-Reactive Protein/Albumin Ratio in Patients With Gynecological Cancers: A Meta-Analysis

2021

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BackgroundMany studies have investigated the prognostic role of the C-reactive protein/albumin ratio (CRP/Alb ratio) in patients with gynecological cancers; however, there is lack of consensus owing to conflicting results across studies. We performed a meta-analysis to determine the prognostic role of the CRP/Alb ratio in gynecological cancers.MethodsWe searched the PubMed, Embase, the Web of Science, Cochrane Library, China National Knowledge Infrastructure, and Wanfang electronic databases since inception to April 2021. Combined hazard ratios (HRs) and 95% confidence intervals (CIs) were used to estimate the prognostic effect of the CRP/Alb ratio in gynecological cancers. Pooled odds ratios (ORs) and 95% CIs were used to investigate the association between the CRP/Alb ratio and clinicopathological features.ResultsThe meta-analysis included seven studies with 1,847 patients. The pooled results showed that a high pretreatment CRP/Alb ratio was associated with poor overall survival (HR, 1.84; 95% CI, 1.41–2.40; p < 0.001) and progression-/disease-free survival (HR, 2.58; 95% CI, 1.42–4.68; p = 0.002). Additionally, a high CRP/Alb ratio was significantly associated with stages III–IV disease (the International Federation of Gynecology and Obstetrics classification) (OR, 2.98; 95% CI, 1.45–6.14; p = 0.003). However, we observed a non-significant correlation between the CRP/Alb ratio and lymph node metastasis, tumor size, and histopathological grade.ConclusionsThe CRP/Alb ratio is a convenient and accurate predictor of survival outcomes in gynecological cancers. A high CRP/Alb ratio also predicts tumor progression.

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The utility of pretreatment systemic inflammatory response biomarkers on overall survival of cervical cancer patients stratified by clinical staging

Cited by 6 publications

References 25 publications

Analysis of Factors Affecting Post-Stroke Fatigue: An Observational, Cross-Sectional, Retrospective Chart Review Study

Analysis of Factors Affecting Post-Stroke Fatigue: An Observational, Cross-Sectional, Retrospective Chart Review Study

Pretreatment Systemic Inflammatory Markers, Neutrophil Lymphocyte Ratio, and Platelet Lymphocyte Ratio as a Prognostic Factor in Cervical Cancer: A Retrospective Study

Prognostic Role of the C-Reactive Protein/Albumin Ratio in Patients With Gynecological Cancers: A Meta-Analysis

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