The utility of serial plasma sE-selectin measurements in the prediction of retinopathy of prematurity in premature infants

Çetınkaya, Merih; Erener-Ercan, Tuğba; Cansev, Mehmet; Büyükkale, Gökhan; Çekmez, Ferhat; Aydemir, Gökhan; Pirhan, Dilara; Genç, Fatih Alparslan; Acar, Esra; Taşkın, Necati

doi:10.1016/j.earlhumdev.2014.03.009

Cited by 4 publications

(4 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several serum/plasma factors including VEGF, 145,163,198,223,300,303,427 bilirubin, 96,113,134,169,178,201,258,416 sE-selectin, 66,304 CRP, 186 apelin, 16 vitamin D, 194 trace elements such as zinc, 407 and inflammatory cytokines such as IL-6 350 have been studied. Although VEGF is a key factor in retinal angiogenesis, studies on systemic levels of VEGF and related factors such as soluble VEGF receptors showed contradictory results.…”

Section: Alternative Risk Factorsmentioning

confidence: 99%

Retinopathy of prematurity: a review of risk factors and their clinical significance

Kim

Port

Swan

et al. 2018

Survey of Ophthalmology

419

337

View full text Add to dashboard Cite

Retinopathy of prematurity (ROP) is a retinal vasoproliferative disease that affects premature infants. Despite improvements in neonatal care and management guidelines, ROP remains a leading cause of childhood blindness worldwide. Current screening guidelines are primarily based on two risk factors: birth weight and gestational age; however, many investigators have suggested other risk factors, including maternal factors, prenatal and perinatal factors, demographics, medical interventions, comorbidities of prematurity, nutrition, and genetic factors. We review the existing literature addressing various possible ROP risk factors. Although there have been contradictory reports, and the risk may vary between different populations, understanding ROP risk factors is essential to develop predictive models, to gain insights into pathophysiology of retinal vascular diseases and diseases of prematurity, and to determine future directions in management of and research in ROP.

show abstract

Section: Alternative Risk Factorsmentioning

confidence: 99%

Retinopathy of prematurity: a review of risk factors and their clinical significance

Kim

Port

Swan

et al. 2018

Survey of Ophthalmology

419

337

View full text Add to dashboard Cite

show abstract

“…However, plasma sE-selectin levels have been studied and were observed to be significantly higher in ROP infants. [ 59 60 ] Observations from the current study suggest the importance of studying the relevance of RANTES-CCL5 and IL-8 in ROP pathogenesis.…”

Section: Discussionmentioning

confidence: 85%

Early detection and correlation of tear fluid inflammatory factors that influence angiogenesis in premature infants with and without retinopathy of prematurity

Vinekar,

Nair,

Sinha

et al. 2023

Indian Journal of Ophthalmology

View full text Add to dashboard Cite

Purpose: To measure the levels of inflammatory factors in tear fluid of pre-term infants with and without retinopathy of prematurity (ROP). Methods: The cross-sectional pilot study included 29 pre-term infants undergoing routine ROP screening. Pre-term infants were grouped as those without ROP (no ROP; n = 14) and with ROP (ROP; n = 15). Sterile Schirmer’s strips were used to collect the tear fluid from pre-term infants. Inflammatory factors such as interleukin (IL)-6, IL-8, MCP1 (Monocyte Chemoattractant Protein 1; CCL2), RANTES (Regulated on Activation, Normal T Cell Expressed and Secreted; CCL5), and soluble L-selectin (sL-selectin) were measured by cytometric bead array using a flow cytometer. Results: Birth weight (BW) and gestation age (GA) were significantly (P < 0.05) lower in pre-term infants with ROP compared with those without ROP. Higher levels of RANTES (P < 0.05) and IL-8 (P = 0.09) were observed in the tear fluid of pre-term infants with ROP compared with those without ROP. Lower levels of tear fluid IL-6 (P = 0.14) and sL-selectin (P = 0.18) were measured in pre-term infants with ROP compared with those without ROP. IL-8 and RANTES were significantly (P < 0.05) higher in the tear fluid of pre-term infants with stage 3 ROP compared with those without ROP. Tear fluid RANTES level was observed to be inversely associated with GA and BW of pre-term infants with ROP and not in those without ROP. Furthermore, the area under the curve and odds ratio analysis demonstrated the relevance of RANTES/BW (AUC = 0.798; OR-7.2) and RANTES/MCP1 (AUC = 0.824; OR-6.8) ratios in ROP. Conclusions: Distinct changes were observed in the levels of tear inflammatory factors in ROP infants. The status of RANTES in ROP suggests its possible role in pathobiology and warrants further mechanistic studies to harness it in ROP screening and management.

show abstract

“…Various studies investigated indicators that could be used to determine development of ROP in the early stage. In the study conducted by Çetinkaya et al (16), it was shown that plasma sE-selectin levels were significantly lower in the early stage in preterm babies who developed ROP compared with those who did not develop ROP.…”

Section: Discussionmentioning

confidence: 99%

“…They also showed that being of black race was protective against ROP (16). Lundgren et al (18) followed up the gestational age and weekly weight gain in babies below the 32 nd gestational week using WINROP (weight, insulin-like growth factor 1, neonatal, retinopathy of prematurity) analysis, which they developed in Sweden and succeeded to determine severe ROP cases with a sensitivity of 95.7%.…”

Section: Discussionmentioning

confidence: 99%

The role of serial measurements of serum insulin-like growth factor 1 levels in the development of retinopathy of prematurity

Dorum¹,

Yılmaz²,

Köksal³

et al. 2017

Turk Pediatri Ars

View full text Add to dashboard Cite

Aim: To determine the role of serum insulin-like growth factor-1 levels in the development of retinopathy of prematurity, which is a major cause of childhood blindness worldwide. Material and Methods: We prospectively studied newborn infants born at a postmenstrual age of <32 weeks and birth weights <1 500 gr, between Results: Among the 40 infants, 11 (27.5%) constituted the retinopathy of prematurity group and 29 comprised the non-retinopathy of prematurity group. In the retinopathy of prematurity group, the mean gestational age and birth weight was significantly lower. The demographic features of the study cohort were similar. The duration of mechanical ventilation was significantly greater in the retinopathy of prematurity group compared with the non-retinopathy of prematurity group (p=0.036). In terms of neonatal morbidities such as respiratory distress syndrome, intraventricular hemorrhage, bronchopulmonary dysplasia, patent ductus arteriosus, and necrotizing enterocolitis, no differences were detected between the groups. The mean serum insulin-like growth factor-1 levels in retinopathy of prematurity group were significantly lower than those in the non-retinopathy of prematurity group at each time point ( Conclusions: This study demonstrated the low serum insulin-like growth factor-1 levels was associated with retinopathy of prematurity development. (Turk Pediatri Ars 2017; 52: 10-4)

show abstract

The utility of serial plasma sE-selectin measurements in the prediction of retinopathy of prematurity in premature infants

Cited by 4 publications

References 33 publications

Retinopathy of prematurity: a review of risk factors and their clinical significance

Retinopathy of prematurity: a review of risk factors and their clinical significance

Early detection and correlation of tear fluid inflammatory factors that influence angiogenesis in premature infants with and without retinopathy of prematurity

The role of serial measurements of serum insulin-like growth factor 1 levels in the development of retinopathy of prematurity

Contact Info

Product

Resources

About