The utility of systemic immune‐inflammation index and systemic immune‐response index in the prediction of adverse outcomes in pregnant women with coronavirus disease 2019: Analysis of 2649 cases

Abstract

Aim To investigate the association of systemic immune‐inflammation index (SII) and systemic immune‐response index (SIRI) with adverse perinatal outcomes in pregnant women with coronavirus disease 2019 (COVID‐19). Methods The cases were divided into (1) the Mild–moderate COVID‐19 group (n = 2437) and (2) the Severe–critical COVID‐19 group (n = 212). Clinical characteristics, perinatal outcomes, SII (neutrophilXplatelet/lymphocyte), and SIRI (neutrophilXmonocyte/lymphocyte) were compared between the groups. Afterward, SII and SIRI values were compared between subgroups based on pregnancy complications, neonatal intensive care unit (NICU) admission, and maternal mortality. A receiver operator characteristic analysis was performed for the determination of optimal cutoff values for SII and SIRI in the prediction of COVID‐19 severity, pregnancy complications, NICU admission, and maternal mortality. Results Both SII and SIRI were significantly higher in complicated cases (p < 0.05). Cutoff values in the prediction of severe–critical COVID‐19 were 1309.8 for SII, and 2.3 for SIRI. For pregnancy complications, optimal cutoff values were 973.2 and 1.6. Cutoff values of 1045.4 and 1.8 were calculated for the prediction of NICU admission. Finally, cut‐off values of 1224.2 and 2.4 were found in the prediction of maternal mortality. Conclusion SII and SIRI might be used in combination with other clinical findings in the prediction of poor perinatal outcomes.

Outcome of pregnant women admitted to critical care unit with confirmed severe COVID-19

“… 12 Similar to APACHI scores, one study used systemic immune-inflammation index (SII) and systemic immune-response index (SIRI) to study the adverse perinatal outcomes in pregnant women with (COVID-19). 13 The study found that both indicators might be used in combination with other clinical findings in the prediction of poor perinatal outcomes including pregnancy complications, NICU admission, and maternal mortality. Moreover, severe COVID-19 cases were shown to have significantly higher rates of inflammatory markers.…”

“…Moreover, severe COVID-19 cases were shown to have significantly higher rates of inflammatory markers. 13 …”

Dois anos de pandemia COVID-19

“…No grupo 1 a idade média materna com desvio padrão era de 28,90 anos e (n=409; 16,8%) tinham idade materna avançada (≥35 anos), (n=27; 1,1%) possuíam HAS, (n=38; 1,6%) asma, (n=21; 0,8) diabetes melittus pré-gestacional e (n=587; 24,1%) apresentaram complicações no período gravídico. No grupo 2 a idade materna média com desvio padrão era de 30,45 anos, (n=58; 27,3%) tinham idade materna avançada, (n=32; 15,1%) eram hipertensas, (n=12; 5,6%) eram asmáticas, (n=11; 5,2%) possuíam diabetes mellitus pré gestacional e (n=190; 89,6%) tiveram complicações na gravidez 18 . Saúde Meio Ambient.…”

The impact of gestational weeks of Coronavirus disease 2019 (COVID-19) infection on perinatal outcomes

“…Accumulating evidence has indicated that pregnant women infected with SARS-CoV-2 usually presents as asymptomatic or mildly symptomatic [ 7 , 8 ], and the clinical course of SARS-CoV-2 infected pregnant women is similar to that of the general population [ 9 ] with low morbidity and mortality rates [ 10 ]. In contrast, conflicting results reporting that infection of COVID-19 during pregnancy may result in a higher risk of obstetric complications and adverse perinatal outcomes [ 11 , 12 ], with significantly higher rates of pregnancy complications were observed in the severe-critical COVID-19 pregnant women [ 13 ]. Furthermore, most of the published data related to COVID-19 and pregnancy come from the analysis of small electronic health records and generally include only third-trimester pregnancies.…”