2008
DOI: 10.1093/jncimonographs/lgn018
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The Utility of t(14;18) in Understanding Risk Factors for Non-Hodgkin Lymphoma

Abstract: Characteristic chromosomal abnormalities are associated with specific histologic subtypes of nonHodgkin lymphoma (NHL). The chromosomal translocation t(14;18)(q32;q21) is one of the most common chromosomal abnormalities in NHL, occurring in 70-90% of cases of follicular lymphoma, 20-30% of diffuse large B-cell lymphoma, and 5-10% of other less common subtypes. The t(14;18)-positive NHL may represent a homogenous group and, consequently, increase etiologic specificity in epidemiologic studies. Although the t(14… Show more

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Cited by 13 publications
(12 citation statements)
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“…Previous studies have observed that cases of NHL positive for the t(14;18) translocation might constitute a more homogenous group of malignancies, including in etiological terms, than NHL as a whole [29]. Taken together our reported findings may add further support to this hypothesis.…”
Section: Discussionsupporting
confidence: 85%
See 1 more Smart Citation
“…Previous studies have observed that cases of NHL positive for the t(14;18) translocation might constitute a more homogenous group of malignancies, including in etiological terms, than NHL as a whole [29]. Taken together our reported findings may add further support to this hypothesis.…”
Section: Discussionsupporting
confidence: 85%
“…However, in this study we did not replicate the previously reported differing associations between t(14;18) ? and t (14;18) -FL related to milk and coffee consumption or cigarette smoking [29][30][31]. The risk associated with pesticide and PCB exposure, lifetime number of surgeries, and a family history of hematopoietic cancer [25,30,32] has also been observed to differ by t(14;18) status, but this information was only available for a small proportion of our cohort and so has not been included in these analyses.…”
Section: Discussionmentioning
confidence: 99%
“…37 It is also possible to examine cytogenetic changes shared by more than one histologic subtype, such as the use of fluorescence in situ hybridization and other techniques to study the t(14;18) translocation. 38,39 These techniques can easily be incorporated in epidemiologic studies using stored biologic specimens. Recommendations for types of specimens to consider collecting are outlined in Table 3.…”
Section: Discussionmentioning
confidence: 99%
“…Use of agrochemicals, including fertilizers, insecticides, and herbicides, is also common. Previous studies indicated that farm-related factors were positively associated with risk of NHL (Pearce and Bethwaite, 1992;Figgs et al, 1995;McDuffie et al, 2002;Chiu et al, 2004). In addition, animal husbandry is well-recognized for its increased risk of exposing a human to transmissible retroviruses, which are known to cause lymphoma (Tranah et al, 2008;Bouvard et al, 2009).…”
Section: Discussionmentioning
confidence: 99%