The utility of tolonium chloride rinse in the diagnosis of recurrent or second primary cancers in patients with prior upper aerodigestive tract cancer

Epstein, Joel B.; Feldman, Roy S.; Dolor, Rowena J; Porter, Stephen

doi:10.1002/hed.10309

Cited by 81 publications

(70 citation statements)

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“…7 On CT, soft tissues within the treatment field may demonstrate inflammatory swelling, fragmentation, and ulceration. 8 However, recurrent tumor may also present clinically as a soft tissue ulceration, [9][10][11] leading to difficulty in the diagnosis and management of these patients.…”

mentioning

confidence: 99%

Benign Ulceration as a Manifestation of Soft Tissue Radiation Necrosis: Imaging Findings

Debnam¹,

Garden²,

Ginsberg³

2008

AJNR Am J Neuroradiol

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mentioning

confidence: 99%

Benign Ulceration as a Manifestation of Soft Tissue Radiation Necrosis: Imaging Findings

Debnam¹,

Garden²,

Ginsberg³

2008

AJNR Am J Neuroradiol

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“…So we should prefer to identify all early oral (pre) malignant lesions in such a high risk population in this study, even lesions with only low grade DP. However, Epstein et al 19,20 regarded carcinoma in situ and invasive carcinoma as histological positive results, while included mild to moderate DP and other benign lesions into negative results. DEtab was color difference between every two shade tabs in the same grade.-2 DE grade was color difference between two adjacent grades.…”

Section: Discussionmentioning

confidence: 99%

Rose bengal staining in detection of oral precancerous and malignant lesions with colorimetric evaluation: A pilot study

Chen

et al. 2007

Intl Journal of Cancer

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Early detection of oral precancerous and malignant lesions is still a diagnostic challenge for most of clinicians, and ideal adjuncts for detection of these lesions are currently unavailable. Our preliminary study has indicated that rose bengal (RB) staining might have the potency as a diagnostic aid; however, its clinical significance and reliability in hospital-based population are still not clear. In the present study, we investigated the efficacy of RB staining in detection of oral precancerous and malignant lesions. RB staining was conducted in 132 patients, and staining results were determined by a 4-graded shade guide, which had been quantitatively measured in the 1976 CIEL*a*b* space by instrumental colorimetry. Histological examination was performed in 128 of 132 patients after RB staining. The sensitivity and specificity to detect epithelial dysplasia (DP) and oral squamous cell carcinoma were 93.9 and 73.7%, respectively. The positive and negative likelihood ratios were 3.570 and 0.082, respectively. Moreover, RB staining seemed promising to detect DP in oral leukoplakia, lichen planus and leukokeratosis. In this study, 5 of 6 DP or oral squamous cell carcinoma were identified by RB staining before histological examination. In conclusion, RB staining may be a valuable diagnostic test in detection of oral precancerous and malignant lesions. ' 2007 Wiley-Liss, Inc.Key words: rose bengal; early detection; oral squamous cell carcinoma; epithelial dysplasia; colorimetry It was estimated that cancer of the head and neck, including all oral, laryngeal and pharyngeal sites, is the fifth most common cancer, accounting for about 615,000 new cases annually. 1 About 40% of head and neck malignancies are known to be squamous cell carcinomas (SCCs) arising in the oral cavity, 1 and it has one of the lowest survival rates, 50%, within a 5-year period. 2 These survival rates have remained relatively unchanged for the past 3 decades, probably because of late recognition of the disease. Consequently, emphasis has been placed on early detection and diagnosis of precancerous lesions and early stages of oral cancer. Nevertheless, oral epithelial lesions have many different presentations, such that clinical variants require diagnostic tests beyond visual examination to obtain definitive diagnoses. [3][4][5] Adjuncts for detection of lesions and selection of biopsy sites include toluidine blue staining, exfoliative cytology and other recently emerging techniques. But because of various reasons, such as less effective when used in oral precancerous lesions, inevitably bewildered when equivocal results occurred, 4,6 these techniques have not been accepted all over the world at present.Rose bengal (RB), the 4,5,6,7-tetrachloro-2 0 ,4 0 ,5 0 ,7 0 -tetraiododerivative of fluorescein, has been widely used to diagnose various ocular surface disorders. 7 It has been believed to stain desquamated ocular epithelial cells, dead or degenerated cells but not healthy epithelial cells, or wherever there is poor protection of the surface e...

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“…El cloruro de tolonio (17), también ha sido utilizado, presentando unos resultados de sensibilidad del 96,7% en algunos casos, a mayor grado de alteración tisular mayor porcentaje de positividad de la prueba.…”

Section: Azul De Metileno Toluidina Y Cloruro De Toloniounclassified

El diagnóstico del cáncer oral en el paciente geriátrico

et al. 2015

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RESUMENEl cáncer oral es una patología frecuente y creciente en el mundo occidental, su incidencia se incrementa año tras año, a pesar de que su localización, en una cavidad fácilmente accesible y explorable permitiría un diagnóstico temprano del mismo, o de las alteraciones potencialmente malignas. Las cifras de nuestro país sitúan una incidencia de 6,7 casos nuevos al año por 100.000 habitantes, con una proporción hombre/mujer de 3 a 1. La proporción de estas neoplasias aumenta de forma gradual con la edad, la posibilidad de que una lesión ulcerosa o proliferativa de cavidad oral, sea un carcinoma es mucho más elevada en pacientes mayores de 65 años. Es nuestra obligación el concienciar a nuestros pacientes, en el cese de hábitos nocivos y en la educación para establecer de la autoexploración una actividad habitual. Sin duda, una exhaustiva exploración física es la primera medida diagnóstica que poseemos asociada ante la mínima sospecha a la realización de una biopsia y el correspondiente estudio histopatológico, que puede establecer la potencialidad maligna de la lesión, así como la evolución de la misma. Disponemos, en la actualidad, de métodos complementarios de diagnósticos, que desde los tradicionales colorantes vitales, pasando por métodos ópticos, hasta la utilización de novedosas técnicas de identificación de receptores moleculares, de alteraciones cromosómicas podrían ser de utilidad en la orientación de factores de riesgo en pacientes predispuestos a padecer la patología, todo ello con el futuro puesto en identificar todos estos riesgos potenciales con un simple análisis de saliva. Lo cierto es que a día de hoy el mejor diagnóstico es la prevención y en el peor de los casos realizarlo lo más precozmente posible para mejorar las perspectivas vitales y la calidad de vida de nuestros pacientes. Palabras clave: Cáncer, precáncer, diagnóstico precoz, paciente geriátrico. SUMMARYOral cancer is a common and growing in the Western world disease, its incidence is increasing year after year, despite its location in an easily accessible and searchable cavity allow early diagnosis thereof, or of potentially malignant disorders. The figures of our country placed an incidence of 6.7 new cases per year per 100,000 population, with a male /female ratio of 3 to 1. It is our duty to educate our patients in the cessation of harmful habits and the Education to establish how to examine a common activity. Definitely a thorough physical examination is the first diagnostic measure we have associated under suspicion for a biopsy and the corresponding histopathology, you can set the malignant potential of the lesion, and the evolution of it. We currently have complementary diagnostic methods, which based from traditional vital dyes, through optical methods, to the use of novel techniques for identifying molecular receptors, chromosomal alterations could be useful in guiding risk factors Patients predisposed to the disease, all in the future on identifying these potential

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The utility of tolonium chloride rinse in the diagnosis of recurrent or second primary cancers in patients with prior upper aerodigestive tract cancer

Abstract: Tolonium chloride rinse is more sensitive than clinical examination alone in detecting lesions that might be found on biopsy to be carcinoma or CIS. The increased sensitivity is largely attributed to lesions that stain but were not detected clinically on visual examination.

Cited by 81 publications

References 40 publications

Benign Ulceration as a Manifestation of Soft Tissue Radiation Necrosis: Imaging Findings

Benign Ulceration as a Manifestation of Soft Tissue Radiation Necrosis: Imaging Findings

Rose bengal staining in detection of oral precancerous and malignant lesions with colorimetric evaluation: A pilot study

El diagnóstico del cáncer oral en el paciente geriátrico

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