The utilization of metal-organic frameworks in tumor-targeted drug delivery systems

Kong, Jiahui; Cai, Mengru; Zhu, Rongyue; Zhang, Yongqiang; Du, Yuji; Jing, Xiaohong; Sun, Yufei; Chang, Rongrong; Qu, Changhai; Dong, Xiaoxv; Ni, Jian; Yin, Xingbin

doi:10.1016/j.jsamd.2024.100770

Journal of Science: Advanced Materials and Devices

2024

DOI: 10.1016/j.jsamd.2024.100770

|View full text |Cite

The utilization of metal-organic frameworks in tumor-targeted drug delivery systems

Jiahui Kong,

Mengru Cai,

Rongyue Zhu

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 172 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Engineering pH and Temperature-Triggered Drug Release with Metal-Organic Frameworks and Fatty Acids

Wei,

2024

Molecules

View full text Add to dashboard Cite

This study reports the successful synthesis of core-shell microparticles utilizing coaxial electrospray techniques, with zeolitic imidazolate framework-8 (ZIF-8) encapsulating rhodamine B (RhB) in the core and a phase change material (PCM) shell composed of a eutectic mixture of lauric acid (LA) and stearic acid (SA). ZIF-8 is well-recognized for its pH-responsive degradation and biocompatibility, making it an ideal candidate for targeted drug delivery. The LA-SA PCM mixture, with a melting point near physiological temperature (39 °C), enables temperature-triggered drug release, enhancing therapeutic precision. The structural properties of the microparticles were extensively characterized through scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and thermogravimetric analysis (TGA). Drug release studies revealed a dual-stimuli response, where the release of RhB was significantly influenced by both temperature and pH. Under mildly acidic conditions (pH 4.0) at 40 °C, a rapid and complete release of RhB was observed within 120 h, while at 37 °C, the release rate was notably slower. Specifically, the release at 40 °C was 79% higher than at 37 °C, confirming the temperature sensitivity of the system. Moreover, at physiological pH (7.4), minimal drug release occurred, demonstrating the system’s potential for minimizing premature drug release under neutral conditions. This dual-stimuli approach holds promise for improving therapeutic outcomes in cancer treatment by enabling precise control over drug release in response to both pH and localized hyperthermia, reducing off-target effects and improving patient compliance.

show abstract

Engineering pH and Temperature-Triggered Drug Release with Metal-Organic Frameworks and Fatty Acids

Wei,

2024

Molecules

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

The utilization of metal-organic frameworks in tumor-targeted drug delivery systems

Cited by 1 publication

References 172 publications

Engineering pH and Temperature-Triggered Drug Release with Metal-Organic Frameworks and Fatty Acids

Engineering pH and Temperature-Triggered Drug Release with Metal-Organic Frameworks and Fatty Acids

Contact Info

Product

Resources

About